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Type 1 diabetes, also known as juvenile-onset or insulin-dependent diabetes mellitus (IDDM), is caused by destruction of insulin-producing ? cells in the pancreas by the body's immune system. It affects hundreds of thousands of individuals worldwide, requiring regular insulin injections to control blood glucose levels and avoid severe consequences of glucose dysregulation. Written by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a detailed examination of our understanding of the disease process and its causes, as well as genetic risk factors, animal models of diabetes, and new treatment strategies that are being developed.
|Publisher:||Cold Spring Harbor Laboratory Press|
|Product dimensions:||7.30(w) x 10.30(h) x 0.80(d)|
Table of Contents
The Pathogenesis and Natural History of Type 1 Diabetes Mark A. Atkinson 1
Breakdown in Peripheral Tolerance in Type 1 Diabetes in Mice and Humans Lukas T. Jeker Hélène Bour-Jordan Jeffrey A. Bluestone 19
Generating β Cells from Stem Cells-The Story So Far Matthias Hebrok 39
Endoplasmic Reticulum Stress, Pancreatic β-Cell Degeneration, and Diabetes Feroz R. Papa 51
Genetics of Type 1 Diabetes Janelle A. Noble Henry A. Erlich 69
Humoral Autoimmunity in Type 1 Diabetes: Prediction, Significance, and Detection of Distinct Disease Subtypes Massimo Pietropaolo Roberto Towns George S. Eisenbarth 85
Immunologic and Metabolic Biomarkers of (β-Cell Destruction in the Diagnosis of Type 1 Diabetes Jasmin Lebastchi Kevan C. Herald 103
Islet Autoantigens: Structure, Function, Localization, and Regulation Peter Arvan Massimo Pietropaolo David Ostrov Christopher J. Rhodes 117
Do MHCII-Presented Neoantigens Drive Type 1 Diabetes and Other Autoimmune Diseases? Philippa Marrack John W. Kappler 137
Antigen Targets of Type 1 Diabetes Autoimmunity Bart O. Roep Mark Peakman 155
The Hygiene Hypothesis: An Explanation for the Increased Frequency of Insulin-Dependent Diabetes Jean-François Bach Lucienne Chatenoud 169
Environmental Triggers of Type 1 Diabetes Mikael Knip Olli Simell 179
Virus Infections in Type 1 Diabetes Ken T. Coppieters Tobias Boettler Matthias von Herrath 195
Connecting Type 1 and Type 2 Diabetes through Innate Immunity Justin I. Odegaard Ajay Chawla 209
Advancing Animal Models of Human Type 1 Diabetes by Engraftment of Functional Human Tissues in Immunodeficient Mice Michael A. Brehm Alvin C. Powers Leonard D. Shultz Dale L. Greiner 227
Antigen-Specific Therapeutic Approaches in Type 1 Diabetes Xavier Clemente-Casares Sue Tsai Carol Huang Pere Santamaria 241
Clinical Immunologic Interventions for the Treatment of Type 1 Diabetes Lucienne Chatenoud Katharina Warncke Anette-G. Ziegler 265
Update on Islet Transplantation Michael McCall A.M. James Shapiro 283