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Series Editors Keith James, University of Edinburgh Medical School, UK Alan Morris, University of Warwick, UK This series is designed to bridge the gap between pure research in the biomedical sciences and its practical application in clinical medicine. The objective is to promote the understanding of the molecular basis of human physiology and disease, and new techniques for diagnosis and treatment. Primarily intended for graduate students of medicine, the books will also be of use to molecular biologists, biochemists, physiologists, pharmacologists and biotechnologists, as well as medical practitioners and technicians who seek to update their knowledge. Vaccine Design Fred Brown, Yale University, USA Gordon Dougan, Imperial College, University of London, UK Elizabeth M. Hoey, Samuel J. Martin, Bertus K. Rima and Alan Trudgett, Queen’s University of Belfast, UK Vaccine Design pulls together the various multidisciplinary approaches that impinge upon the production and use of vaccines against viruses, bacteria and parasites. Recent developments in our understanding of the biochemistry and molecular genetics of pathogenic agents and the unravelling of the complexities of the immune system have opened up new possibilities for vaccination, many of which still have to be fully exploited. This book discusses the basic molecular and immunological techniques and concepts that are essential components of any research into vaccine development. Vaccine Design is aimed primarily at senior undergraduate and postgraduate research students who are studying any aspect of vaccines.
Table of Contents
A Short History of Vaccination.
Sequence Analysis: A Starting Point for Vaccine Design.
Requirements for the Induction of Immunity.
Prediction of Epitopes.
Peptides as Vaccines.
Vaccines Against Virus Diseases.
Possibilities for Future Vaccines.