This new book uniquely integrates the diversity of research and interest regarding the chemistry, analysis, physiology, genetics, and clinical aspects of vitamin K and vitamin K-dependent proteins. Featuring state-of-the-art reviews of analytical methods used in various fields of study relating to vitamin K this book demonstrates how methodological advances are advancing our knowledge in these fields. Topics covered include the hemostatic function; congenital deficiencies and role in malignancy of vitamin K-dependent procoagulants and anticoagulants; etiology, diagnosis, and prevention of vitamin K deficiency in the newborn; and biochemical perspectives of vitamin K deficiency or antagonism induced by antibiotics or coumarin drugs.
Vitamin K and Vitamin K-Dependent Proteins also discusses the physiology and diagnostic role of the bone-protein osteocalcin and other non-coagulation vitamin K-dependent proteins. The book is an indispensable reference for hematologists, biochemists, physiologists, and nutrition researchers.
|Publisher:||Taylor & Francis|
|Product dimensions:||6.50(w) x 9.50(h) x 1.00(d)|
Table of Contents
Changes in the Activity States of Vitamin K-Dependent Proteins in Hypercoagulability: Some Conceptual and Methodological Aspects (M.J. Seghatchian). The Exploitation of the Electrochemical Properties of K Vitamins From Their Sensitive Measurement in Tissues (J. Hart). Reaction Detection Methods for K Vitamins and Their 2', 3' - Epoxy Metabolite in Liquid Chromatography (Y. Haron). Advances in the Assessment of Activation States of Factor VII in Hypercoagulable States: Some Epidemiological Aspects and Laboratory Approaches for Assay of Factor VII and Tissue Factor Pathway Inhibitor (M.J. Seghatchian). An Activated Form of Factor VII in Plasma: A New Link between Lipids and Clotting (H. Prydz). Changes in the Activity States of the Protein C, Protein S Systems and Hypercoagulability (M.J. Seghatchian). Protein C and Proteins S: Methodological and Clinical Aspects (C. Boyer-Neumann, M. Wolf, and M.J. Larrieu). Congenital Deficiencies of the Vitamin K-Dependent Clotting Factors (G. Mariani, A. Ghirardini, and G. Iacopino). Recent Advances in the Molecular and Functional Patterns of Congential Deficiencies of the Vitamin K-Dependent Clotting Factors (G. Mariani and M. Papacchini). Vitamin K Dependent Proteins in Malignancy (J.L. Francis). Vitamin K-Deficiency in the Newborn: Historical Perspectives, Diagnosis and Prevention (W.E. Hathaway). Vitamin K Deficiency in the Newborn: Etiology and Influence of Infant Physiology and Maternal Nutrition (R. von Kries). Antibiotic-Induced Hypoprothrombinemia: Biochemical Mechanism and Clinical Significance (J.W. Suttie). The Relationship between the Disposition and Pharmacological Response to Phylloquinone (Vitamin K1) during Coumarin Anticoagulation (B.K. Park and M.J. Winn). Methods for the Measurements of Urinary Gamma-Carboxyglutamic Acid and Serum Osteocalcin and Their Use in the Clinical Situation as Markers of Bone Disease (C.M. Gundberg). Extra-Hepatic Gla-Containing Proteins in the Human (C. Vermeer and M.H.J. Knapen).