Jenna, Sam, and Lola are still alive. Jenna avoids human contact, traveling East Coast backroads with her boyfriend, a dog named Chicken, and a Louisville Slugger. Sam escapes to the mountains, where he's conscripted into a zombie-slaying militia sent on nightly raids to kill the undead...and innocent civilians. Lola's imprisoned in the "safety" of a zombie-free New Orleans hotel, but life grows more dangerous when her brother gets bitten by a zombie.
Jenna arrives in the French Quarter, lured by the false promises of New Orleans' drunken leader. There, she's ripped away from her boyfriend, drugged, and dumped in a death camp after refusing Franklin's sexual advances. Jenna and Lola's lives collide there, where the dead live and the dying are victims of gruesome medical experiments.
Escape isn't easy: release the genetically-enhanced zombies from the lab to create a diversion, slip away, and don't get eaten. When Sam arrives, will he join the right side of the battle?