Bioinformatics for Geneticists / Edition 1

Bioinformatics for Geneticists / Edition 1

by Michael R. Barnes
     
 

ISBN-10: 0470843934

ISBN-13: 9780470843932

Pub. Date: 04/04/2003

Publisher: Wiley

This work describes a step-by-step approach to key bioinformatics and genetic analysis procedures, and features detailed case studies of problems and analytical approaches specific to the needs of the genetics researcher. Bioinformatics tools and genetic databases are also reviewed. Material is written to capture the principles of analysis regardless of the tool used,…  See more details below

Overview

This work describes a step-by-step approach to key bioinformatics and genetic analysis procedures, and features detailed case studies of problems and analytical approaches specific to the needs of the genetics researcher. Bioinformatics tools and genetic databases are also reviewed. Material is written to capture the principles of analysis regardless of the tool used, ensuring that the book stays relevant. The editors are affiliated with GlaxoSmithKline Pharmaceuticals, UK. Annotation (c)2003 Book News, Inc., Portland, OR

Product Details

ISBN-13:
9780470843932
Publisher:
Wiley
Publication date:
04/04/2003
Series:
Hierarchical Exotoxicology Mini Series, #1
Pages:
422
Product dimensions:
6.22(w) x 9.09(h) x 1.13(d)

Table of Contents

List of contributors
Foreword
Sect. IAn Introduction to Bioinformatics for the Geneticist1
Ch. 1Introduction: The Role of Genetic Bioinformatics3
Ch. 2Internet Resources for the Geneticist21
Ch. 3Human Genetic Variation: Databases and Concepts39
Ch. 4Finding, Delineating and Analysing Genes71
Sect. IIThe Impact of Complete Genome Sequences on Genetics93
Ch. 5Assembling a View of the Human Genome95
Ch. 6Mouse and Rat Genome Informatics119
Ch. 7Genetic and Physical Map Resources - An Integrated View143
Sect. IIIBioinformatics for Genetic Study Design163
Ch. 8From Linkage Peak to Culprit Gene: Following Up Linkage Analysis of Complex Phenotypes with Population-based Association Studies165
Ch. 9Genetic Studies from Genomic Sequence179
Ch. 10SNP Discovery and PCR-based Assay Design: From In Silico Data to the Laboratory Experiment203
Ch. 11Tools for Statistical Analysis of Genetic Data217
Sect. IVBiological Sequence Analysis and Characterization247
Ch. 12Predictive Functional Analysis of Polymorphisms: An Overview249
Ch. 13Functional In Silico Analysis of Non-coding SNPs273
Ch. 14Amino Acid Properties and Consequences of Substitutions289
Sect. VGenetics/Genomics Interfaces317
Ch. 15Gene Expression Informatics and Analysis319
Ch. 16Proteomic Informatics345
Ch. 17Concluding Remarks: Final Thoughts and Future Trends373
Appendix I379
Appendix II381
Glossary387
Index391

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