Bioinformatics for Geneticists / Edition 1

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2003 Hardcover Good Item may show signs of shelf wear. Pages may include limited notes and highlighting. Includes supplemental or companion materials if applicable. Access ... codes may or may not work. Connecting readers since 1972. Customer service is our top priority. Read more Show Less

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Overview

This timely book illustrates the value of bioinformatics, not simply as a set of tools but rather as a science increasingly essential to navigate and manage the host of information generated by genomics and the availability of completely sequenced genomes. Bioinformatics can be used at all stages of genetics research: to improve study design, to assist in candidate gene identification, to aid data interpretation and management and to shed light on the molecular pathology of disease-causing mutations. Written specifically for geneticists, this book explains the relevance of bioinformatics showing how it may be used to enhance genetic data mining and markedly improve genetic analysis.
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Editorial Reviews

From the Publisher
"…a very valuable and important resource for bringing bioinformatics into the work practice of geneticists." (Clinical Chemistry, December 2004)

"..valuable in this newly emerging discipline called 'Bioinformatics'." (Journal of Statistical Computation & Simulation, September 2004)

"Although this book is aimed primarily at professional geneticists, the numerous worked examples would be useful to anyone putting a course together on this topic.” (Biochemistry and Molecular Education, May/ June 2004)

"...This book is essential reading for all those engaged in genetic research and should prove indispensable ...." (CAB Abstracts)

"...a useful addition to the library of a seasoned scientist...a useful resource in itself, cataloguing the 'how' and 'why' ..." (Briefings in Bioinformatics, June 2004)

"…a very valuable and important resource for bringing bioinformatics into the work practice of geneticists…we strongly recommend this book..." (Clinical Chemistry, 2004)

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Product Details

  • ISBN-13: 9780470843932
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 4/4/2003
  • Series: Hierarchical Exotoxicology Mini Series , #1
  • Edition number: 1
  • Pages: 422
  • Product dimensions: 6.22 (w) x 9.09 (h) x 1.13 (d)

Table of Contents

List of contributors
Foreword
Sect. I An Introduction to Bioinformatics for the Geneticist 1
Ch. 1 Introduction: The Role of Genetic Bioinformatics 3
Ch. 2 Internet Resources for the Geneticist 21
Ch. 3 Human Genetic Variation: Databases and Concepts 39
Ch. 4 Finding, Delineating and Analysing Genes 71
Sect. II The Impact of Complete Genome Sequences on Genetics 93
Ch. 5 Assembling a View of the Human Genome 95
Ch. 6 Mouse and Rat Genome Informatics 119
Ch. 7 Genetic and Physical Map Resources - An Integrated View 143
Sect. III Bioinformatics for Genetic Study Design 163
Ch. 8 From Linkage Peak to Culprit Gene: Following Up Linkage Analysis of Complex Phenotypes with Population-based Association Studies 165
Ch. 9 Genetic Studies from Genomic Sequence 179
Ch. 10 SNP Discovery and PCR-based Assay Design: From In Silico Data to the Laboratory Experiment 203
Ch. 11 Tools for Statistical Analysis of Genetic Data 217
Sect. IV Biological Sequence Analysis and Characterization 247
Ch. 12 Predictive Functional Analysis of Polymorphisms: An Overview 249
Ch. 13 Functional In Silico Analysis of Non-coding SNPs 273
Ch. 14 Amino Acid Properties and Consequences of Substitutions 289
Sect. V Genetics/Genomics Interfaces 317
Ch. 15 Gene Expression Informatics and Analysis 319
Ch. 16 Proteomic Informatics 345
Ch. 17 Concluding Remarks: Final Thoughts and Future Trends 373
Appendix I 379
Appendix II 381
Glossary 387
Index 391
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