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More About This Textbook
Overview
In this book structural principals of proteins are reviewed and analysed from a geometric perspective with the aim of revealing the underlying regularities in their construction. - Willie Taylor - a recognised leader in mathematical biology/theoretical molecular biology - Protein folding determines function of protein - key research area in molecular biology and biochemistry. Computational power now means problems governing folding can be handled quantitatively. - Reviews principles of protein folding and computational techniques employed - A key area of biophysics - interfaces with many other disciplines. "The work is aimed at readers from the physical sciences and each topic is explained from first principles with an emphasis on basic concepts rather than applications. Despite this, little technical or mathematical knowledge is required and the methods should be easily accessible to readers with a more biological background. While the book would be suitable as a source of projects for undergraduate courses, it is primarily aimed at students on post-graduate courses (MSc, MRes,PhD) and researchers involved in investigation of protein structures."—BOOK JACKET. Title Summary field provided by Blackwell North America, Inc. All Rights Reserved (Blackwell)
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Table of Contents
INTRODUCTION
Prologue
Basic Principles of Protein Structure
GEOMETRY
Ellipsoids and Embedding
Geometric Representations of Structure
Distance Geometry
Sticks to Strings
Secondary Structure Geometries
Simplified Architectures
Sheets and Barrels
Beta-Sheet Geometry
Beta-Barrels
CLASSIFICATION
Networks and Domains
Hydrogen-Bond Networks
Protein Domain Definitions
Protein Structure Comparison
Overview of Comparison Methods
Assessment of Significance
Classification and Fold Spaces
Protein Structure Classification
Protein Fold Spaces
A "Periodic Table" for Protein Structures
Evolutionary'steps in fold-space
TOPOLOGY
Folds, Tangles and Knots
Topology and Knots
Random Walks in Fold-Space
Protein Fold Complexity
Structure Prediction and Modelling
Random Folds from Distance Geometry
Modelling with Distance Geometry
Protein Tertiary Structure Prediction
SYMMETRY
Structural Symmetry
Symmetry
A Fourier Analysis of Symmetry
Evolution and Origins
Evolution of Structure and Function
The Origins of Proteins
The Secret of Life
References
Index