With a regionally diverse group of writers, this richly interwoven collection explores in depth the work of well-known figures such as Pauline Johnson, Sarah Winnemucca and Zitkala-ea, as well as less familiar writers such as Narcissa Owen, Buffalo Bird Woman, Mary Jemison, Ora Eddleman Reed, Sophia Alice Callahan, Owl Woman and Annette Leevier. Anonymously authored "women's texts" are also included, along with writing by children and young adults.

Karen Kilcup challenges traditional mainstream notions of what constitutes literature, including political, historical, and autobiographical writing alongside more familiarly "aesthetic" forms like romantic poetry, short fiction and spiritual literature. As well as representing traditional oral narratives, the collection invites readers to hear the "translation" of orality into written forms.

Brief headnotes outline the writers' lives and indicate connections between and among the writers. The volume also includes brief bibliographies of primary and secondary materials for each writer.

A key text for the classroom, Native American Women's Writing: An Anthology c. 1800-1924 offers an inviting wealth of newly discovered material for scholars and general readers alike.