Lane analyzes four kinds of challenges to interdependency, all of which are growing in geopolitical relevance. First, countries need to diminish their dependency on fossil fuel and shift to a reliable supply of energy, because fossil fuels are diminishing. Second, environmental degradation must be addressed, because it is accelerating under the strain of earth's population. Lane advocates an ecological footprint approach. Third, a single global market economy and its complexities must be addressed, as national economies are increasingly opened. Finally, as traditional state sovereignty weakens, foreign military intervention in both international and intra-state conflicts increases.

Governments are attempting to address these interdependencies, or reply to the challenges they pose, mainly through international organizations and regionalism. These efforts are discussed at length. In addition, problems with international law are reviewed, as Lane warns against the utopian hopes of global constitutionalism. Globalization also examines the potential consequences of failing to address the need for coordination in efforts to address shared global challenges.