Guidelines for Laboratory Design: Health, Safety, and Environmental Considerations / Edition 4

Guidelines for Laboratory Design: Health, Safety, and Environmental Considerations / Edition 4

ISBN-10:
0470505524
ISBN-13:
9780470505526
Pub. Date:
04/08/2013
Publisher:
Wiley
ISBN-10:
0470505524
ISBN-13:
9780470505526
Pub. Date:
04/08/2013
Publisher:
Wiley
Guidelines for Laboratory Design: Health, Safety, and Environmental Considerations / Edition 4

Guidelines for Laboratory Design: Health, Safety, and Environmental Considerations / Edition 4

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Overview

Proven and tested guidelines for designing ideal labs for scientific investigations

Now in its Fourth Edition, Guidelines for Laboratory Design continues to enable readers to design labs that make it possible to conduct scientific investigations in a safe and healthy environment. The book brings together all the professionals who are critical to a successful lab design, discussing the roles of architects, engineers, health and safety professionals, and laboratory researchers. It provides the design team with the information needed to ask the right questions and then determine the best design, while complying with current regulations and best practices.

Guidelines for Laboratory Design features concise, straightforward advice organized in an easy-to-use format that facilitates the design of safe, efficient laboratories. Divided into five sections, the book records some of the most important discoveries and achievements in:

  • Part IA, Common Elements of Laboratory Design, sets forth technical specifications that apply to most laboratory buildings and modules
  • Part IB, Common Elements of Renovations, offers general design principles for the renovation and modernization of existing labs
  • Part II, Design Guidelines for a Number of Commonly Used Laboratories, explains specifications, best practices, and guidelines for nineteen types of laboratories, with three new chapters covering nanotechnology, engineering, and autopsy labs
  • Part III, Laboratory Support Services, addresses design issues for imaging facilities, support shops, hazardous waste facilities, and laboratory storerooms
  • Part IV, HVAC Systems, explains how to heat, cool, and ventilate labs with an eye towards energy conservation
  • Part V, Administrative Procedures, deals with bidding procedures, final acceptance inspections, and sustainability

The final part of the book features five appendices filled with commonly needed data and reference materials.

This Fourth Edition is indispensable for all laboratory design teams, whether constructing a new laboratory or renovating an old facility to meet new objectives.


Product Details

ISBN-13: 9780470505526
Publisher: Wiley
Publication date: 04/08/2013
Edition description: 4th ed.
Pages: 560
Product dimensions: 8.50(w) x 11.10(h) x 1.30(d)

About the Author

LOUIS J. DiBERARDINIS, BS, MS, CIH, CSP, is the Director of Environment, Health, and Safety at MIT. He is a visiting lecturer at Harvard University School of Public Health and Adjunct Professor at the University of Massachusetts Lowell in the Department of the Work Environment. He received his BS in chemical engineering from Northeastern University and an MS in industrial hygiene from Harvard University.

JANET S. BAUM, BS, MArch, AiA, currently teaches part-time at Harvard University School of Public Health and at both the Graduate School of Architecture and Urban Design and the Institute of Public Health, Washington University in St. Louis. She earned her BS in architectural sciences at Washington University in St. Louis and her master of architecture at Harvard University Graduate School of Design.

The late MELVIN W. FIRST, ScD, CIH, PE, was a researcher and professor of environmental health Engineering at the Harvard School of Public Health for almost sixty years and was actively involved in research until a week before his death.

GARI T. GATWOOD, BSME, CSP (retired), is a consultant in safety engineering. He has forty years of safety experience in missile defense, commercial chemicals, laboratories, and university programs. He holds a degree in mechanical engineering from the Missouri School of Mines and Metallurgy in Rolla, Missouri.

Anand K. Seth, BS, MS, PE, CEM, CPE, is currently an Engineering Principal in Cannon Design, an international architectural/engineering firm. Seth worked at Massachusetts General Hospital as director of engineering and at Harvard University. He holds a master of science in mechanical engineering from the University of Maine and has done postgraduate work at other universities.

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Table of Contents

Foreword xv

Preface xvii

Acknowledgments xix

About the Authors xxi

Abbreviations xxiii

Units xxv

Organizations Referenced xxvii

Introduction xxix

How to Use This Book xxx

Book Organization xxxi

Computational Fluid Dynamics xxxiii

Part IA Common Elements of Laboratory Design 1

1 Building Considerations 3

1.1 Guiding Concepts 3

1.2 Building Layout 3

1.3 Guiding Principles for Building Heating Ventilating and Air-Conditioning Systems 44

1.4 Guiding Concepts for Laboratory Building Loss Prevention Industrial Hygiene and Personal Safety 51

1.5 Miscellaneous Services 56

2 Laboratory Considerations 65

Part IB Common Elements of Renovations 109

3 Renovations: Building Considerations 123

3.1 Guiding Concepts 123

3.2 Building Layout 125

3.3 Heating Ventilating and Air-Conditioning Systems 129

3.4 Loss Prevention Industrial Hygiene and Personal Safety 133

3.5 Miscellaneous Services 134

4 Renovations: Laboratory Considerations 136

4.1 Guiding Concepts 136

4.2 Laboratory Layout 137

4.3 Heating Ventilating and Air-Conditioning Systems 138

4.4 Loss Prevention Industrial Hygiene and Personal Safety 138

Part II Design Guidelines for a Number of Commonly Used Laboratories 141

5 General or Analytical Chemistry Laboratory 143

5.1 Description 143

5.2 Laboratory Layout 144

5.3 Heating Ventilating and Air-Conditioning 146

5.4 Loss Prevention Industrial Hygiene and Personal Safety 149

5.5 Special Requirements 149

6 High-Toxicity Laboratory 150

6.1 Description 150

6.2 Laboratory Layout 151

6.3 Heating Ventilating and Air-Conditioning 153

6.4 Loss Prevention Industrial Hygiene and Personal Safety 154

6.5 Special Requirements 155

7 Nanotechnology Laboratories 156

7.1 Description 156

7.2 Laboratory Layout 156

7.3 Heating Ventilating and Air-Conditioning 157

7.4 Loss Prevention Industrial Hygiene and Personal Safety 158

8 Engineering Laboratories 160

8.1 Description 160

8.2 Engineering Disciplines and Some of Their Most Common Laboratory Types 160

8.3 Wind Tunnel Laboratory 161

8.4 Jet and Rocket Propulsion Laboratory 162

8.5 Hydraulics Laboratory 164

8.6 Material Analysis and Testing Laboratory 165

8.7 Electrical Circuits Motors and Generators Laboratory 165

8.8 Foundry Laboratory 167

8.9 Internal Combustion and Gas Turbine Engine Laboratory 169

9 Pilot Plant: Chemical Engineering and Biological 173

9.1 Description 173

9.2 Pilot Plant Layout 174

9.3 Heating Ventilating and Air-Conditioning 174

9.4 Loss Prevention Industrial Hygiene and Personal Safety 175

9.5 Special Requirements 175

10 Physics Laboratory 177

10.1 Description 177

10.2 Laboratory Layout 178

10.3 Heating Ventilating and Air-Conditioning 179

10.4 Loss Prevention Industrial Hygiene and Personal Safety 179

10.5 Special Requirements 181

11 Controlled Environment Room: Hot or Cold 182

11.1 Description 182

11.2 Laboratory Layout 183

11.3 Heating Ventilating and Air-Conditioning 183

11.4 Loss Prevention 185

11.5 Special Requirements 185

12 High-Pressure Laboratory 187

12.1 Description 187

12.2 Laboratory Layout 188

12.3 Heating Ventilating and Air-Conditioning 188

12.4 Loss Prevention Industrial Hygiene and Personal Safety 189

12.5 Special Requirements 189

13 Radiation Laboratory 190

13.1 Description 190

13.2 Laboratory Layout 191

13.3 Heating Ventilating and Air-Conditioning 194

13.4 Loss Prevention Industrial Hygiene and Personal Safety 195

13.5 Special Considerations 195

14 Biosafety Laboratory 196

14.1 Description 196

14.2 Laboratory Layout 202

14.3 Heating Ventilating and Air-Conditioning 212

14.4 Loss Prevention Industrial Hygiene and Personal Safety 213

14.5 Special Requirements 213

15 Clinical Laboratories 216

15.1 Description 216

15.2 Laboratory Layout 218

15.3 Heating Ventilating and Air-Conditioning 222

15.4 Loss Prevention Industrial Hygiene and Personal Safety 223

16 Teaching Laboratory 227

16.1 Description 227

16.2 Laboratory Layout 228

16.3 Heating Ventilating and Air-Conditioning 234

16.4 Loss Prevention Industrial Hygiene and Personal Safety 235

17 Gross Anatomy Laboratory 238

17.1 Description 238

17.2 Laboratory Layout 239

17.3 Heating Ventilating and Air-Conditioning 243

17.4 Loss Prevention Industrial Hygiene and Personal Safety 244

17.5 Security 245

18 Pathology Laboratory 246

18.1 Description 246

18.2 Laboratory Layout 249

18.3 Heating Ventilating and Air-Conditioning 251

18.4 Loss Prevention Industrial Hygiene and Personal Safety 251

18.5 Special Requirements 252

19 Autopsy Laboratory 253

19.1 Description 253

19.2 Laboratory Layout 255

19.3 Heating Ventilating and Air-Conditioning 260

19.4 Loss Prevention Industrial Hygiene and Personal Safety 261

20 Morgue Facility 262

20.1 Description 262

20.2 Laboratory Layout 265

20.3 Heating Ventilating and Air-Conditioning 269

20.4 Loss Prevention Industrial Hygiene and Personal Safety 269

21 Open or Team Research Laboratory 271

21.1 Description 271

21.2 Laboratory Layout 272

21.3 Heating Ventilating and Air-Conditioning 275

21.4 Loss Prevention Industrial Hygiene and Personal Safety 275

21.5 Special Considerations 276

22 Animal Research Laboratory 277

22.1 Description 277

22.2 Laboratory Layout 279

22.3 Heating Ventilating and Air-Conditioning 292

22.4 Loss Prevention Industrial Hygiene and Personal Safety 296

22.5 Special Requirements 297

23 Microelectronics and Cleanroom Laboratories 299

23.1 Description 299

23.2 Laboratory Layout 303

23.3 Heating Ventilating and Air Conditioning 307

23.4 Loss Prevention Industrial Hygiene and Personnel Safety 310

23.5 Special Requirements 312

23.6 Renovations 314

24 Printmaking Studio 315

24.1 Description 315

24.2 Print Studio Layout 317

24.3 Heating Ventilating and Air-Conditioning 318

24.4 Loss Prevention Industrial Hygiene and Personal Safety 321

Part III Laboratory Support Services 325

25 Imaging and Photographic Facilities 327

25.1 Introduction 327

25.2 Photographic And Imaging Facility Layouts 331

25.3 Heating Ventilating and Air-Conditioning 334

25.4 Loss Prevention Industrial Hygiene and Personal Safety 336

25.5 Special Requirements 337

26 Support Shops 339

26.1 Description 339

26.2 Layout 340

26.3 Heating Ventilating and Air-Conditioning 344

26.4 Loss Prevention Industrial Hygiene and Personal Safety 346

26.5 Special Requirements 346

27 Hazardous Chemical Radioactive and Biological Waste-Handling Rooms 348

27.1 Guiding Concepts 348

27.2 Layout 351

27.3 Heating Ventilating and Air-Conditioning 356

27.4 Loss Prevention Industrial Hygiene and Personal Safety 358

27.5 Special Requirements 358

28 Laboratory Storerooms 360

28.1 Description 360

28.2 Layout 363

28.3 Heating Ventilating and Air-Conditioning 366

28.4 Loss Prevention Industrial Hygiene and Personal Safety 367

28.5 Special Requirements 368

Part IV Hvac Systems 369

29 HVAC Systems 371

29.1 Description 371

29.2 Air-Conditioning Systems 371

29.3 HVAC System Design and Description 376

29.4 System Descriptions and Strategies 377

29.5 Humidification and Dehumidification 386

29.6 Space Pressure Control 389

29.7 Automatic Control System 391

30 Fans 392

30.1 Fan Terminology 392

30.2 Exhaust Fan Specifications 393

30.3 Atmospheric Dispersion 394

30.4 Fan Laws 394

30.5 Fan Selection 395

30.6 Fan Performance 396

31 Air Cleaning 397

31.1 Introduction 397

31.2 Air-Cleaning Equipment for Laboratories 398

32 Laboratory Hoods and Other Exhaust Air Contaminant-Capture Facilities and Equipment 404

32.1 Introduction 404

32.2 Conventional Bypass Chemical Fume Hoods 405

32.3 Auxiliary Air Chemical Fume Hoods 409

32.4 Perchloric Acid Fume Hoods 411

32.5 Hoods for Work With Radioactive Materials 411

32.6 Variable Air-Volume Hoods 411

32.7 High-Performance Hoods 412

32.8 Gloveboxes 412

32.9 Biological Safety Cabinets 413

32.10 Capture (Exterior) Hoods 416

32.11 Ductless Hoods 416

32.12 Performance Tests 420

33 Exhaust Air Ducts and Accessories 422

33.1 Introduction 422

33.2 Exhust Duct Considerations 423

33.3 Exhust System Classification 424

33.4 Duct Accessories 424

34 Variable-Air-Volume Systems 426

34.1 Introduction 426

34.2 VAV Hoods 427

34.3 Good Design Practices for Vav Systems 428

34.4 Variable-Volume Exhaust System Operational Concept 428

34.5 VAV System Controls and Components 429

34.6 VAV System Fan Controls and Components 431

34.7 VAV System Duct Configurations 434

35 Energy Conservation 436

35.1 Introduction 436

35.2 Recent Trends 437

35.3 Exhaust Ventilation for Contamination Control 440

35.4 Lighting 448

35.5 Thermal Insulation 448

35.6 Humidity Control 448

35.7 Evaporative Cooling 449

35.8 Water Conservation 449

35.9 Efficient Operating Strategies 449

Part V Administrative Procedures 451

36 Project Execution and Bidding Procedures 453

36.1 Guiding Concepts 453

36.2 Implementation 454

36.3 Bid Form 456

36.4 Contract 457

36.5 Change Orders 457

36.6 Construction Inspections 458

36.7 Punch List 458

36.8 Additional Testing and Acceptance 458

36.9 Beneficial Occupancy 459

36.10 Final Acceptance and Commissioning 459

37 Commissioning and Final Acceptance Criteria 460

37.1 Guiding Concepts 460

37.2 Design Construction and Preoccupancy Checklists 460

37.3 Heating Ventilating and Air-Conditioning 462

37.4 Loss Prevention Industrial Hygiene and Personal Safety 466

37.5 Project Commissioning 467

38 Sustainable Laboratory Design 471

38.1 Introduction 471

38.2 Laboratory Construction Materials 472

38.3 Heating Ventilating and Air-Coniditioning 474

38.4 Loss Prevention Industrial Hygiene and Personal Safety 477

38.5 Miscellaneous Services 477

38.6 Lighting 478

38.7 Submetering 479

38.8 Additional Background Material 479

Part VI Appendixes 481

Appendix A Emergency Showers 483

Appendix B Emergency Eyewash Units 485

Appendix c Signs 486

Appendix D Stack Design 489

Appendix E Matrix of Building Consideration for Specific Laboratory Types 495

References 500

Index 509

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