Cerebral palsy (CP) is an extremely heterogeneous condition. There is any number of aetiological pathways possible for causing brain damage to the developing fetus and into early childhood, and these are morphing and changing over time. There are also numerous clinical manifestations of CP encompassing: different motor types, topographies, gross motor function levels, manual abilities, intellectual, communication, behavioral, sensory, abilities and impairments. Understanding the risk factors and complex causal pathways to CP has been a slow and protracted process. This handbook discusses the risk factors of cerebral palsy, as well as the therapeutic management options, and long-term prognosis of the condition.