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Omics Approaches in Breast Cancer: Towards Next-Generation Diagnosis, Prognosis and Therapy

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ISBN-10:: 8132234723
ISBN-13:: 9788132234722
Pub. Date:: 10/27/2015
Publisher:: Springer India

ISBN-10:: 8132234723
ISBN-13:: 9788132234722
Pub. Date:: 10/27/2015
Publisher:: Springer India

Omics Approaches in Breast Cancer: Towards Next-Generation Diagnosis, Prognosis and Therapy

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Overview

Breast cancer is the most common cancer in females that accounts for highest cancer specific deaths worldwide. In the last few decades research has proven that breast cancer can be treated if diagnosed at early stages and proper therapeutic strategy is adopted. Omics-based recent approaches have unveiled the molecular mechanism behind the breast tumorigenesis and aid in identification of next-generation molecular markers for early diagnosis, prognosis and even the effective targeted therapy. Significant development has taken place in the field of omics in breast cancer in the last decade. The most promising omics approaches and their outcomes in breast cancer have been presented in this book for the first time. The book covers omics technologies and budding fields such as breast cancer miRNA, lipidomics, epigenomics, proteomics, nutrigenomics, stem cell, pharmacogenomics and personalized medicine and many more along with conventional topics such as breast cancer management etc. It is a research-based reference book useful for clinician-scientists, researchers, geneticists and health care industries involved in various aspects of breast cancer. The book will also be useful for students of biomedicine, pathology and pharmacy.

Product Details

ISBN-13:	9788132234722
Publisher:	Springer India
Publication date:	10/27/2015
Edition description:	Softcover reprint of the original 1st ed. 2014
Pages:	545
Product dimensions:	7.01(w) x 10.00(h) x (d)

About the Author

Dr Debmalya Barh is the founder of Institute of Integrative Omics and Applied Biotechnology (IIOAB) at Nonakuri, Tamluk, West Bengal, India. His core competencies include bioinformatics, genome, genomics and proteomics, cell signaling, integrative omics based marker and target discovery, cancer pharmacogenomics, personalized medicine, cardiovascular and infectious diseases. He has been a consultant for three top healthcare and diagnostic companies in USA. He is the reviewer/editorial board member of many journals like CMAJ, Molecular Medicine, Bioinformatics, BMC Genomics, BMC Systems Biology, Journal of Medical Informatics, Current Oncology, Gene Therapy, J. Cardiovascular Dis Res, J Integrated Omics, AIOAB. He has several scientific publications including genome sequences, journal articles, book chapters and reference books.

Part I: Omics Approaches in Breast Cancer
Omics Technologies Applied in Breast Cancer Research.- Omics of Hereditary Breast Cancer.- Oncogenes and Tumor Supressor Genes as a Biomarker in Breast Cancer.- Breast Cancer Genomics.- Epigenomics of Breast Cancer.- Nutrigenomics in Breast Cancer.- Long Non-coding RNAs in Breast Cancer: Implications for Pathogenesis, Diagnosis and Therapy.- Breast Cancer MicroRNAs: Clinical Biomarkers for the Diagnosis and Treatment Strategies.- Breast Cancer Proteomics.- Metabolomics in Breast Cancer.- Lipidomics in Breast Cancer.- Breast Cancer Stem Cells and Cellomics.- Omics of Male Breast Cancer.- Omics of Chemoresistant and Metastatic Breast Cancer.- Animal Models of Breast Cancer.- In Silico Disease Models of Breast Cancer.- Systems Biology and Integrative Omics in Breast Cancer.- Gynecologic Considerations for Women with Breast Cancer.- Imaging Technologies and Applications in Early Diagnosis and Prognosis for Breast Cancer.- Breast Cancer Biomarkers for Risk Assessment, Screening, Detection, Diagnosis and Prognosis.- Breast Circulating Tumor Cells: Potential Biomarkers for Breast Cancer Diagnosis and Prognosis Evaluation.- Molecular Diagnosis Of Metastasizing Breast Cancer Based Upon Liquid Biopsy.- Exhaled Volatile Organic Compounds as Non-Invasive Markers in Breast Cancer.- Breast Cancer Therapy–Classical Therapy, Drug Targets and Targeted Therapy.- Pharmacogenomics–Pharmacoepigenomics of Breast Cancer Therapy: Clinical Implications.- Breast Cancer Gene Therapy.- Clinical Trial Endpoints in Breast Cancer.

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Editorial Reviews

From the book reviews:

“This will be valuable for those who are interested in learning about various ‘omics’ approaches, findings in breast cancers through bioinformatics studies, and technical considerations of breast cancer diagnosis and treatment. … this book is well structured and contains an abundance of published findings. The area of ‘omics’ is essential to breast cancer research, and this book nicely summarizes and presents up-to-date findings.” (Shiuan Chen, Doody’s Book Reviews, March, 2015)

From the Publisher

Reviewer: Shiuan Chen, Ph.D.(City of Hope)
Description: Over the last 15 years, the "omics" approaches have significantly enhanced our understanding of the molecular features of breast cancer subtypes. Various bioinformatics techniques and analyses have been developed to assess molecular events during the development of breast malignancy. Such knowledge is valuable for exploring new targeted therapies for different subtypes of breast cancers. This book includes contributions from 65 experts in nearly 20 countries who review a variety of "omics" approaches and findings in breast cancer using these analyses and present translational research reports in which "omics" data have been used for the diagnosis, prognosis, and treatment.
Purpose: The purpose is to provide a comprehensive collection of reviews on the characterization of breast cancers through analyses at the levels of genomics, epigenomics, nutrigenomics, long noncoding RNAs, miRNAs, proteomics, metabolomics, and lipidomics. The book also includes several reviews of breast cancer models, such as stem cells, animal models, in silico analysis, and integrative omics. The book ends with 10 reviews of key considerations of breast cancer diagnosis, biomarker study, and therapeutic designs based on "omics" information.
Audience: This will be valuable for those who are interested in learning about various "omics" approaches, findings in breast cancers through bioinformatics studies, and technical considerations of breast cancer diagnosis and treatment.
Features: The editor makes a significant effort to include a broad variety of reviews of different bioinformatics analyses. They are inclusive and current, with most citing references up to 2013. The reviews are The efforts to link molecular information from the "omics" studies to clinically relevant issues are recognized. The "Conclusion and Future Perspective" section at the end of each chapter is critical for readers' understanding of the current status of each approach and the challenges moving forward. The book is clearly written and easy to follow. It is certainly helpful that tables are used to summarize key findings for each "omics" approach. There are a couple of shortcomings. One is insufficient emphasis on breast cancer subtypes. The "omics" approaches have supported the presence of several subtypes, e.g., hormone-responsive, HER2-overexpressing, and triple negative breast cancers. The biological and molecular features of these subtypes are very different, impacting on the mechanisms of cancer development and treatment strategies. The other is the lack of an index, which would be useful for readers wishing to review specific topics.
Assessment: Overall, this book is well structured and contains an abundance of published findings. The area of "omics" is essential to breast cancer research, and this book nicely summarizes and presents up-to-date findings. This is also a nice reference for those wishing to learn different "omics" approaches and the information generated from these bioinformatics analyses.

Doody's Review Service

Omics Approaches in Breast Cancer: Towards Next-Generation Diagnosis, Prognosis and Therapy

Omics Approaches in Breast Cancer: Towards Next-Generation Diagnosis, Prognosis and Therapy

Paperback

Overview

Product Details

About the Author

Table of Contents

Customer Reviews

Overview

Product Details

About the Author

Table of Contents

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Customer Reviews