Table of Contents

Risk Assessment for Pharmaceutical Products.- Reproductive Toxicity Risk Assessment — Some Questions.- Biomarkers of Developmental Neurotoxicity.- A Call for Increased Flexibility in Current Teratogenicity Testing.- Specific and Non-Specific Developmental Effects.- Assessment of Reproductive Toxicology of Drugs at the Food and Drug Administration.- New Approaches to Developmental Toxicity Risk Assessment at the U.S. Environmental Protection Agency.- Scientific Basis for Risk Assessment (Reproductive Toxicity) for Pesticides as Practiced by the Bundesgesundheitsamt (BGA).- Scientific Basis for Risk Assessment (Reproductive Toxicity) in Ecotoxicology as Practiced by the Federal Environmental Agency (Umweltbundesamt).- General Discussion: Choice of Species.- Scientific Basis for Risk Assessment (Reproductive Toxicity) for Medicinal Products as Practiced in Germany and the European Community (EC).- Risk Assessment in Reproductive Toxicology as Practiced in South America.- Reproductive Hazard Evaluation and Risk Assessment under California’s Proposition 65.- General Discussion: Risk Assessment.- Statistical Problems (and Some Solutions) Associated with Testing for Effects in Developmental Toxicology.- Aspects of Concentration-Response Analysis.- Dose-Response Relationships in Reproductive Toxicology: Importance of Skeletal Variations.- Prenatal-Toxic Risk Estimation Based on Dose-Response Relationships and Molecular Dosimetry.- Kinetic Problems Arising in a Multigeneration Study.- Application of Mathematical Dose-Response Models vs. Physiological Models in Risk Assessment in Reproductive Toxicology.- General Discussion: Use of Biologically Based Models.- Pharmacoknetics and Drug Metabolism in the Design and Interpretation of Developmental Toxicity Studies.- Feasibilityof Studying Effects on the Immune System in Non-Human Primates.- Marmosets (Callithrix jacchus) as Useful Species for Toxicological Risk Assessments.- Planning and Performance of Segment I, II and III Experiments: Practical Aspects and General Comments.- Significance of Postnatal Manifestations of Prenatally-Induced Effects (Behaviour).- Significance of Prenatally or Early Postnatally-Induced Organ Dysfunctions — Other than CNS Defects.- Quantitative Morphological Tests for Evaluation of Testicular Toxicity.- Morphological Changes in Cultures of Hippocampus Following In Vitro Irradiation.- Possible Contribution of In Vitro Methods to Risk Assessment in Reproductive and Developmental Toxicology.- Morphological Endpoints in In Vitro Testing.- Significance of Epidemiological Studies for Risk Assessment in Prenatal Toxicity.- Maternal Thyroid Autoantibodies and Fetal Thyroid Growth.- Pre- and Postnatal Risk Factors for the Development of Atopy in Childhood.- Does Smoking During Pregnancy Alter Brain Perfusion in the Neonate? A Doppler Study.- Risk Assessment of Tocolytic Therapy in Pregnancy.- Hishemical and Immunocyhemical Investigations of the Fetal Extravascular and Vascular Contractile System in the Normal Placenta and During Preeclampsia.- Some Data on the Pattern of Lymphocyte Subsets in Blood During the Perinatal Period.