Table of Contents

I Embryology of the Male Reproductive Tract.- Embryology of the Testis.- Hormonal Factors in the Development of the Male Genital System.- The Relationship Between Differentiation of the Testicle, Genital Ducts and External Genitalia in Fetal and Postnatal Life.- Heteroplastic Gonaduct-Testes Combinations: A Biochemical Outlook.- II Histology of the Testis.- Dynamics of Human Spermatogenesis.- Electron Microscopy of the Human Seminiferous Tubules.- Fine Structure of Testicular Interstitial Cells in Humans.- Histology of the Human Testis from Neonatal Period to Adolescence.- III Cytogenetics of Spermatogenesis.- Morphological Aspects of Meiosis and Their Genetical Significance.- Ultrastructure and Hishemistry of the Nucleus During Male Meiotic Prophase.- The Cytogenetics of the Male Germ Cells and the Testis in Mammals.- Chromosome Studies on Testicular Cells of Subfertile Men.- IV Regulation of Testicular Function.- Section 1: Role of the Hypothalamus.- Mechanism of Action of FSH and LH Releasing Factors.- Hypothalamic Control of Gonadotropin Secretion in the Male.- Purification and Chemistry of Gonadotropin Releasing Factors.- Further Studies on Mechanism of Action of Luteinizing Hormone Releasing Factor Using In Vivo and In Vitro Techniques.- Section 2: Testicular-Pituitary Interrelationship.- Investigations Into the Feed-Back Mechanism Between Spermatogenesis and Gonadotropin Level in Man.- The Role of FSH, ICSH, and Endogenous Testosterone During Testicular Suppression by Exogenous Testosterone in Normal Men.- Section 3: Gonadotropins, Purification and Measurement.- Use of Standards in Gonadotropin Assays.- Preparations and Biological Characteristics of HMG Preparations Used Clinically.- Plasma FSH and LH Measured by Radioimmunoassay in Normal and Pathologic Conditions in Men.- Section 4: Metabolic Effects of Gonadotropins.- Early Effects of FSH upon Testicular Metabolism.- Radioautographic Studies of Protein Synthesis in Cells of the Seminiferous Epithelium.- Studies of Spermatogenesis and Steroid Metabolism in Cultures of Human Testicular Tissue.- Section 5: Influence of Gonadotropins on Testicular Functio.- Effect of Gonadotropins on the Seminiferous Tubules of the Immature Testis.- Ultrastructural and Chemical Effects of LH upon the Seminiferous Tubule.- Biologic Effect of Human Pituitary Luteinizing Hormone and Human Chorionic Gonadotropin.- The Effect of Gonadotropins on the Prepubertal Testis.- V Testicular Steroidogenesis.- Steroid Secretion by the Human Testis.- Testosterone Plasma Levels in Normal and Pathological Conditions.- Relation of In Vitro Metabolism of Steroids in Human Testicular Tissue to Histologic and Clinical Findings.- Subcellular Structure and Synthesis of Steroids in the Testis.- VI Non-Hormonal Factors Influencing Sperm Production and Transport.- The Biochemical Characteristics of Spermatozoa and Seminal Plasma.- The Significance of Deviations in Human Sperm Morphology.- Pharmacological Studies on the Testicular Capsule in Relation to Sperm Transport.- Effect of Gonadotropins and Androgens on Fructose and Citric Acid of Seminal Fluid.- Immunological Aspects of Male Infertility.- VII Gonadotropin Therap.- Section 1: Treatment of Hypopituitarism.- Effects of HCG, HMG, HLH, and HGH Administration on Testicular Function.- Effect of Urinary FSH and LH on the Testicular Function in Hypogonadal Patients.- The Effects of Urinary Gonadotropins Following Hypophysectomy and in Hypogonadotropic Eunuchoidism.- Section 2: Treatment of Adult Seminiferous Tubular Failure.- Assessment of Gonadotropin Therapy in Infertile Males.- Assessment of Gonadotropin Therapy in Male Infertility.- Assessment of Gonadotropin Therapy in Male Infertility.- Concluding Remarks.