Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves

Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves

by George M Church, Edward Regis
Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves

Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves

by George M Church, Edward Regis

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Overview

A Harvard biologist and master inventor explores how new biotechnologies will enable us to bring species back from the dead, unlock vast supplies of renewable energy, and extend human life.

In Regenesis, George Church and science writer Ed Regis explore the possibilities of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies-far from the out-of-control nightmare depicted in science fiction-have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.

Product Details

ISBN-13: 9780465075706
Publisher: Basic Books
Publication date: 04/08/2014
Pages: 304
Sales rank: 403,882
Product dimensions: 6.00(w) x 9.10(h) x 0.90(d)
Age Range: 18 Years

About the Author

George M. Church is professor of genetics at the Harvard Medical School and member of the Wyss Institute of Biologically Inspired Engineering.

Ed Regis is author of seven science books, most recently What Is Life? Investigating the Nature of Life in the Age of Synthetic Biology.

Read an Excerpt

Regenesis

How Synthetic Biology Will Reinvent Nature and Ourselves


By George M. Church

Perseus Books Group

Copyright © 2014 George M. Church
All rights reserved.
ISBN: 978-0-465-07570-6


Prologue: From Bioplastics to H. sapiens

1. -3,800 Myr, Late Hadean
At the Inorganic/Organic Interface

2. -3,500 Myr, Archean
Reading the Most Ancient Texts and the Future of Living Software

3. -500 Myr, Cambrian
The Mirror World and the Explosion of Diversity. How Fast Can Evolution Go and How Diverse Can It Be?

4. -360 Myr, Carboniferous
"The Best Substitute for Petroleum Is Petroleum”

5. -60 Myr, Paleocene
Emergence of Mammalian Immune System. Solving the Health Care Crisis Through Genome Engineering

6. -30,000 yr, Pleistocene Park
Engineering Extinct Genomes

7. -10,000 yr, Neolithic
Industrial Revolutions. The Agricultural Revolution and Synthetic Genomics. The BioFab Manifesto

8. -100 yr, Anthropocene
The Third Industrial Revolution. iGEM

9. -1 yr, Holocene
From Personal Genomes to Immortal Human Components

Epigenetic Epilogue: +1 yr, The End of the Beginning, Transhumanism, and the Panspermia Era
Societal Risks and Countermeasures

(Continues...)

Excerpted from Regenesis by George M. Church. Copyright © 2014 George M. Church. Excerpted by permission of Perseus Books Group.
All rights reserved. No part of this excerpt may be reproduced or reprinted without permission in writing from the publisher.
Excerpts are provided by Dial-A-Book Inc. solely for the personal use of visitors to this web site.

Table of Contents

Wall Street Journal
“In Regenesis… George Church and Ed Regis imagine a world where micro-organisms are capable of producing clean petroleum or detecting arsenic in drinking water, where people sport genetic modifications that render their bodies impervious to the flu, or where a synthetic organism can be programmed to invade and destroy cancer cells.”

Nature
“The life sciences emerge as the new high-tech in this paean to synthetic biology.... Each step in the genome’s evolution serves as a springboard for expositions of how synthetic biology will revolutionize renewable energy, multivirus resistance, and more.”

New Scientist
“Bold and provocative…Church and Regis offer a behind-the-scenes look at synthetic biology, a rapidly emerging field that is reprogramming the genetic code to create organisms and functions not found in nature. Regenesis tells of recent advances that may soon yield endless supplies of renewable energy, increased longevity, and the return of long-extinct
species.... Thought-provoking.”

io9
“[A] phenomenal read.”

Publishers Weekly
“Exhilarating and scary facts suffuse this book about bioengineering by leading Harvard genetics professor and entrepreneur Church.... When Church describes current work building microbes with minimal genes, the book takes off—and eventually soars.... [A] stimulating book.”

Kirkus Reviews
“[An] authoritative, sometimes awe-inspiring book.... A valuable glimpse of science at the edge.”

Steven Pinker, Harvard College Professor of Psychology, Harvard University, and author of How the Mind Works and The Better Angels of Our Nature
“A thoughtful introduction to one of the great frontiers of science, one with the promise of literally saving the world.... Engaging, readable, and thoroughly fascinating.”

Choice
"Geneticist Church and science writer Regis take a novel evolutionary approach to explaining the science of synthetic biology.... [A] highly readable book."

What People are Saying About This

From the Publisher

Science News
“Reading the first book penned by Church, a Harvard biologist and polymath, is like falling down a rabbit hole straight into his fermenting brain. Church’s wide-ranging career includes developing novel methods for reading the genetic instruction manual, or genome, of creatures from bacteria to humans. Now he focuses on synthesizing those instructions from scratch.... [A] dizzying survey of how scientists have unearthed the secrets of living organisms and are now using that information to revamp life itself.”

Robert T. Gonzalez, io9
“[A] phenomenal read.”

Wall Street Journal
“A definitive account of the advances and business ventures that define this new science [of synthetic biology]…. When history is written centuries from now, it is more likely that writing DNA will be the most enduring innovation [of our age].”

New Scientist
“Bold and provocative… Church and Regis offer a behind-the-scenes look at synthetic biology, a rapidly emerging field that is reprogramming the genetic code to create organisms and functions not found in nature. Regenesis tells of recent advances that may soon yield endless supplies of renewable energy, increased longevity and the return of long-extinct species.”

Nature
“The life sciences emerge as the new high-tech in this paean to synthetic biology…. Each step in the genome’s evolution serves as a springboard for expositions of how synthetic biology will revolutionize renewable energy, multivirus resistance, and more.”

Mike Loukides, O’Reilly Radar
“If there’s one book that can turn this movement into a full-blown revolution, this is it.”

Derek Jacoby, O’Reilly Radar
“George Church and Ed Regis pull off an exciting and speculative romp through the field of synthetic biology and where it could take us in the not too distant future…. Regenesis provides an accessible and engaging introduction to the revolutionary potentials of synthetic biology and should be of interest to both experts and a general science audience.”

The Scientist
“[A]n important and surprisingly accessible book, magisterially structured to intertwine the accelerated history of synthetic biology with its precedents in humanity’s earlier technological revolutions and in the epochal evolution of life itself. The book packs in a superb short course on life’s molecular workings, enabling the reader to grasp how we can actually contemplate resurrecting mammoths and Neanderthals, brewing biofuel from seawater and sunlight, engineering total immunity to viral infection, storing data in DNA, and more.”

Nathan Myhrvold, Founder and CEO, Intellectual Ventures
“A delightfully opinionated, visionary and controversial romp through synthetic biology, which is one of the most important technologies of our time."

Eric Topol, Professor of Genomics, The Scripps Research Institute, and author of The Creative Destruction of Medicine
“Literally reinventing nature could provide solutions to intractable problems with the energy supply, global warming, and human health. In Regenesis, George Church, a pioneer and pre-eminent force in promoting our ability to read DNA sequence, now guides us to the future: writing DNA sequence. Teaming up with Ed Regis, Church provides a mind-bending, tour de force account of how this seventh industrial revolution will take hold, and how ultimately the survival of our planet and the human species may rely upon rewriting the code of life. An enthralling journey into the future—with truly profound implications—that should not be missed.”

Stewart Brand, author of Whole Earth Discipline
“Here you will find the bleeding, screaming, thrilling edges of what is becoming possible with genomic engineering, handsomely framed in the fine-grained fundamentals of molecular biology. It is a combination primer and forecast of what is coming in this ‘century of biology’ from the perspective of a leading pioneer in the science.”

Kirkus Reviews
“[An] authoritative, sometimes awe-inspiring book…. A valuable glimpse of science at the edge.”

Publishers Weekly
“Exhilarating and scary facts suffuse this book about bioengineering by leading Harvard genetics professor and entrepreneur Church…. [W]hen Church describes current work building microbes with minimal genes, the book takes off – and eventually soars…. [A] stimulating book.”

Steven Pinker, Harvard College Professor of Psychology, Harvard University, and author of How the Mind Works and The Better Angels of Our Nature
“A thoughtful introduction to one of the great frontiers of science, one with the promise of literally saving the world. George Church is one of the most brilliant scientists in the world, and in collaboration with Ed Regis he has written a book that is engaging, readable, and thoroughly fascinating.”

J. Craig Venter, Chairman and President, J. Craig Venter Institute
“Church and Regis in Regenesis have written a wonderful synopsis of the emerging field of synthetic biology and the implications from renewable plastics to ‘raising the dead.’ This is a must-read for anyone interested in the future.”

Misha Angrist, Assistant Professor, Duke Institute for Genome Sciences & Policy, and author of Here is a Human Being
Regenesis is the most compelling bit of prophecy since the Old Testament first came out in hardback.”

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