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Ageless: The New Science of Getting Older Without Getting Old

Ageless: The New Science of Getting Older Without Getting Old

by Andrew Steele


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A startling chronicle by a brilliant young scientist takes us to the frontiers of the science of aging, and reveals how close we are to an astonishing extension of our life spans and a vastly improved quality of life in our later years.

Aging—not cancer, not heart disease—is the true underlying cause of most human death and suffering. We accept as inevitable that as we advance in years our bodies and minds begin to deteriorate and that we are ever more likely to be felled by dementia or disease. But we never really ask: Is aging necessary? Biologists, on the other hand, have been investigating that question for years. After all, there are tortoises and salamanders whose risk of dying is the same no matter how old they are. With the help of science, could humans find a way to become old without getting frail, a phenomenon known as “biological immortality”?

In Ageless, Andrew Steele, a computational biologist and science writer, takes us on a journey through the laboratories where scientists are studying every bodily system that declines with age—DNA, mitochondria, stem cells, our immune systems—and developing therapies to reverse the trend. With clarity and intellectual passion, Steele shines a spotlight on a little-known revolution already under way.

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Product Details

ISBN-13: 9780385544924
Publisher: Knopf Doubleday Publishing Group
Publication date: 03/23/2021
Pages: 352
Sales rank: 34,911
Product dimensions: 6.40(w) x 9.00(h) x 1.40(d)

About the Author

After obtaining a PhD in physics from the University of Oxford, ANDREW STEELE decided that ageing was the most important scientific challenge of our time and switched fields to computational biology. He worked at the Francis Crick Institute, using machine learning to decode our DNA and predict heart attacks using patients' medical records. He is now a full-time science writer and presenter based in London. He has appeared on Discovery and the BBC.

Table of Contents

Introduction 1

Part I I An Age-Old Problem

1 The Age of Aging 17

2 On the Origin of Aging 32

3 The Birth of Biogerontology 52

4 Why We Age 70

Part II Treating Aging

5 Out with the Old 111

6 In with the New 138

7 Running Repairs 169

8 Reprogramming Aging 207

Part III Living Longer

9 The Quest for a Cure 241

10 How to Live Long Enough to Live Even Longer 246

11 From Science to Medicine 270

Acknowledgments 285

Notes and Bibliography 289

Index 329

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