Angiogenesis in Health, Disease and Malignancy

by Ali Salajegheh

Overview

This book is about “Angiogenesis”. A process in which new vasculature is formed from pre-existing capillaries. Angiogenesis process is associated with the proliferation and growth of both physiologically normal and neoplastic tissues, through the formation of vascular supply, essential for delivering growth requirements such as oxygen and nutrients.

The book describes more than 100 genes and their key regulatory functions in the context of normal healthy condition, disease and malignancy, cancer proliferation and progression. New insights into the role of angiogenesis and the therapeutic inhibition of its regulators are investigated, due to the great potential for exploitation in the development of a novel treatment for cancer.

New scientists, junior researchers and biomedical science students will find this book an invaluable introductory reference to their insight about angiogenesis and angiogenic role of more than 100 angiogenes and their role in healthy, disease and malignant conditions.

Product Details

ISBN-13:	9783319802817
Publisher:	Springer International Publishing
Publication date:	04/26/2018
Edition description:	Softcover reprint of the original 1st ed. 2016
Pages:	423
Product dimensions:	6.10(w) x 9.25(h) x (d)

Table of Contents

1. Introduction to Angiogenesis in Normal Physiology. Disease and Malignancy

2. Adenosine triphosphate-binding cassette (ABC) lipid transporters

3. Angiogenin

4. Angiopoietins

5. Angiotropin

6. C-KIT: tyrosine kinase receptors with potential to initiate

7. CCND1 and E1

8. Cluster of Differentiation 71 (CD71)

9. Connective Tissue Growth Factor (CTGF)

10. COX10

11. Cysteine-rich 61 (Cyr61)

12. Epidermal growth factor

13. Epidermal growth factor domain-like 7 (EGFL7)

14. Erythropoietin-producing hepaellular receptors A: Ephrin A1, Ephrin A2 and Ephrin A3

15. Erythropoietin-producing hepaellular receptors B: Ephrin B2, Ephrin B4

16. Ets-1

17. Fibrin

18. Fibroblast growth factors (Acidic: FGF-1; Basic: FGF-2) and its receptors (FGFR)

19. Fibronectin

20. Granulocyte-Macrophage and Granulocyte Colony Stimulating Factor (GM-CSF and G-CSF)

21. GAX and HOXA5

22. Heparanase

23. Hepayte Growth Factor (HGF)

24. HIF-1α

25. Insulin-like growth factor

26. Integrins (αv1β3, αv1β5, β8)

27. Interleukins

28. Insulin receptor substrate (IRS1)

29. Iron-sulfur clusters (ISCU)

30. MDM4

31. Matrix Metalloproteinase 2 (MMP2)

32. Monobutyrin

33. Neutrophil activating protein-2 (NAP-2)

34. p27kip1 and p57Kip2 (CDKN1B and CDKN1C)

35. Platelet-derived endothelial cell growth factor (PDGF)

36. Prolyl hydroxylase domain-2 (PHD-2)

37. Phosphatidylinositol-4, 5-bisphosphate 3-kinase (PIK3Ca)

38. PIK3R2 (p85β) - Phosphatidylinositol 3-kinase β-subunit

39. Platelet-activating factor

40. Placenta growth factor (PlGF)

41. Preproendothelin-1 (PreproET-1)

42. Proliferin

43. Prostaglandins

44. ROS1

45. SIRT1

46. SMAD4 (Mothers against Decapentaplegic Homolog 4)

47. Sprouty-Related, EVH1 Domain-containing protein 1 (SPRED-1)

48. Signal transducer and activator of transcription of 5A and S3 (STAT5 and STATS3)

49. SUFU

50. Tenascins

51. Tissue inhibitor of metalloproteinases 1 and 2 (TIMP-1 and TIMP-2)

52. Tissue factor gene

53. Transforming growth factor α and β (TGF- α and TGF- β)

54. Transforming growth factor beta-receptor type II (TGFβR2)

55. TSP-1

56. Tumour necrosis factor-α (TNF-α)

57. Urokinase plasminogen activator

58. Vascular Endothelial Growth Factor (VEGF)

59. Vascular cell adhesion molecule-1 (VCAM-1)

60. Vascular endothelial (VE)-Cadherin

61. Zinc Finger E-Box Binding Homeobox 1 (ZEB1)

62. Miscellaneous genes involved in Angiogenesis in Normal Physiology, Disease and Malignancy