Biochemical Oscillations and Cellular Rhythms: The Molecular Bases of Periodic and Chaotic Behaviour

by Albert Goldbeter, M. J. Berridge (Foreword by)

Overview

This book addresses the molecular bases of some of the most important biochemical rhythms known at the cellular level. The approach rests on the analysis of theoretical models closely related to experimental observations. Among the main rhythms considered are glycolytic oscillations observed in yeast and muscle, oscillations of cyclic AMP in Dictyostelium amoebae, intracellular calcium oscillation observed in a variety of cell types, the mitotic oscillator that drives the cell division cycle in eukaryotes, pulsatile hormone signaling, and circadian rhythms in Drosophila. This book will be of interest to life scientists such as biochemists, cell biologists, chronobiologists, medical scientists and pharmacologists. In addition, it will appeal to scientists studying nonlinear phenomena, including oscillations and chaos, in chemistry, physics, mathematics and theoretical biology.

Product Details

ISBN-13:	9780521599467
Publisher:	Cambridge University Press
Publication date:	04/03/1997
Edition description:	New Edition
Pages:	632
Product dimensions:	6.02(w) x 9.02(h) x 1.50(d)

Table of Contents

1. Introduction; Part I. Glycolytic Oscillations: 2. Oscillatory enzymes: simple periodic behaviour in an allosteric model for glycolytic oscillations; Part II. From Simple to Complex Oscillatory Behaviour; 3. Birhythmicity: coexistence between two stable rhythms; 4. From simple periodic behaviour to complex oscillations, including bursting and chaos; Part III. Oscillations Of Cyclic Amo In Dictyostelium Cells: 5. Models for the periodic synthesis and relay of camp signals in Dictyostelium discoideum amoebae; 6. Complex oscillations and chaos in the camp signalling system of Dictyostelium; 7. The onset of camp oscillations in Dictyostelium as a model for the ontogenesis of biological rhythms; Part IV. Pulsatile Signalling In Intercellular Communication: 8. Function of the rhythm of intercellular communication in Dictyostelium. Link with pulsatile hormone secretion; Part V. Calcium Oscillations: 9. Oscillations and waves of intracellular calcium; Part VI. The Mitotic Oscillator: 10. Modelling the mitotic oscillator driving the cell division cycle; Part VII. Circadian Rhythms: 11. Towards a model for circadian oscillations in the Drosophila period protein (PER); 12. Conclusions and perspectives; References.

Editorial Reviews

"The book beautifully illustrates the art of modeling...It is an excellent read and will appeal to a wide ranging audience..." Philip K. Maini, Trends in Biochemical Sciences

"A scintillating book...The importance of its contribution to the field is crystal clear." Ernst Knobil, University of Texas Health Science Center, Houston

"...a very impressive tome and is a superb addition to the literature. It is quite clearly going to be the reference book on oscillations." James D. Murray, University of Washington, Seattle

"Albert Goldbeter...is a reliable guide through the intricacies of the biochemistry and mathematics...The great strength of the book is his unshrinking dedication to understanding these processes from start to finish...the book is conversational, clear, and accurate...The only way to understand these biological rhythms...is to become more quantitative and to develop rigorous mathematical models. Albert Goldbeter is at the very forefront of this new approach." John J. Tyson, Nature

"...will not only serve as a guide to the most interesting questions in the field of rhythms, chaos and nonlinear models but also open up new research themes. It is of interest for a wide audience of chemists, physicists, biologists, medical scientists and mathematicians who look for interesting application fields....a source of sustained intellectual joy." Andreas Deutsch, Biomathematics Newsletter

"...contains an impressive compilation of the literature in the field....will undoubtedly become a classic in the field of mathematical modelling of cellular processes....I will enjoy having the book on my bookshelf for consultation, and I am confident that it will serve me well for many years." Lars Folke Olsen, Bulletin of Mathematical Biology

"[The book]...will be of value to chemists and mathematicians who are interested in the biological applications of their field. It provides a comprehensive account of a new field and makes it abundantly clear that this is only the beginning of what might be a means of brininging together areas that have, until now, seemed rather far apart. I recommend this book for its data, its approach, its ideas, and for the way in which it introduces the whole concept of oscillation in biological systems." Jim M. Waterhouse, BioEssays

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