Biology and Physiology of the Blood-Brain Barrier: Transport, Cellular Interactions, and Brain Pathologies

by Pierre-Olivier Couraud (Editor), Daniel Scherman (Editor)

Overview

The endothelial cells of the cerebral vasculature constitute, together with perivascular elements (astrocytes, pcricytes, basement membrane), the blood-brain barrier (BBB), which strictly limits and specifically controls the exchanges between the blood and the cerebral extracellular spacc.The existence of such a physical, enzymatic, and active barrier isolating the central nervous system has broad physiological, biological, pharmacological, and patho­ logical consequences, most of which are not yet fully elucidated. The Cerebral Vascular Biology conference (CVB '95) was organized and held at the "Carre des Sciences" in Paris on July I 0-12, 1995. Like the CVB '92 conference held in Duluth, Minnesota, three years ago, the objectives were to provide a forum for presentation of the most recent progresses and to stimulate discussions in the ticld of the biology, physiology. and pathology of the blood-brain barrier. The Paris conference gathered more than !50 participants. including investigators in basic neuroscience, physicians. and students, who actively contributed to the scientific program by their oral or poster presentations. This volume contains a collection of short articles that summarize most of the new data that were presented at the conference. Six thematic parts focus on physiological transports. drug delivery, multidrug resistance P-glycoprotein, signal transduction at the BBB. interactions between the immune system and the cerebral endothelial cells, and the blood-brain barrier-related pathologies in the central nervous system. In addition, two introductory articles present new insights in the rapidly evolving topics of cerebral angiogenesis and gene transfer to the brain.

Product Details

ISBN-13:	9780306453625
Publisher:	Springer US
Publication date:	12/31/1996
Series:	Advances in Behavioral Biology , #46
Edition description:	1996
Pages:	388
Product dimensions:	7.01(w) x 10.00(h) x 0.28(d)

Table of Contents

Introductory Overviews.- I: Physiological Transports through the Blood-Brain Barrier.- II: Blood-Brain Barrier and Drug Delivery to the Brain.- III: Multidrug Resistance P-Glycoprotein at the Blood-Brain Barrier.- IV: Signal Transduction in Brain Endothelial Cells.- V: Interactions—Leukocytes-Brain Endothelial Cells.- VI: Brain Pathologies and Blood-Brain Barrier.

Editorial Reviews

This book contains a collection of short articles that summarize new data regarding the pathology and physiology of the blood-brain barrier that were presented at the Cerebral Vascular Biology Conference held in Paris in 1995. The editors do not state any specific objectives. The editors do not clearly state for whom the book is written. I believe that it is written for researchers in this field. It may be of some use to practitioners who work with the central nervous system. The book is aptly illustrated. The references are current and pertinent. The table of contents is adequate, but the index is not. The overall appearance of the book is very good. The book may be of use to researchers in this field to update them about the latest developments in the area. It may be of some use to practitioners who work with the central nervous system. It may be a useful addition to a library. It is a reasonably good book.

P. S. Mohankumar

A collection of 63 articles summarizing most of the new data presented at a July 1995 conference in Paris. The general themes are physiological transports, drug delivery, multidrug resistance P-glycoprotein, signal transduction at the barrier, interactions between the immune system and the cerebral endothelial cells, and the pathologies in the central nervous system that relate to the barrier. Introductory overviews discuss the development of blood- brain barrier endothelial cells, and prospects for neuroprotective gene therapy for neurodegenerative diseases. Annotation c. by Book News, Inc., Portland, Or.

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