Cardiac Bioelectric Therapy: Mechanisms and Practical Implications
Pacing and defibrillation have become the leading therapeutic treatments of heart rhythm disorders, including bradycardia and tachycardia. The success of these therapies is largely due to centuries of scientific inquiry into the fundamental mechanisms of bioelectric phenomena in the heart. History of successful development of bioelectric therapies includes development of experimental and theoretical methodologies, novel bioengineering approaches, and state-of-the-art clinical implantable device therapies.

The purpose of this book is to present a uniform thematic collection of reviews written by the leading basic and applied scientists working in basic bioengineering research laboratories, who have contributed to the development of current understanding of the fundamental mechanisms of pacing and electrophysiology, and who are at the leading edge of further developments in electrotherapy.

The book will start from the historic overview of the subject, including the development of the pacemaker and defibrillator, evolution of theories of cardiac arrhythmias and experimental methods used in the field over the centuries. Leading experts in the field will write these chapters. The second part of the book will focus on rigorous treatment of the fundamental theory of interaction between electric field and cardiac cell, tissue, and organ. Chapters will be written by top notch scientists, who made critically important contributions to the development of these theories. Part 3 will provide summary of several decades of research involving electrode recordings and multielectrode mapping of ventricular fibrillation and defibrillation in humans and animal models of arrhythmias. Part 4 will present new insights into defibrillation gained due to the advent of optical imaging technology, which permitted to map defibrillation without overwhelming shock-induced artifacts present in electrode recordings. Part 5 will provide rigorous overview of themethodologies, which made research of physiological and engineering aspects of electrotherapy possible. And finally, part 6 will present possible future of implantable devices and electrotherapy in the treatment of cardiac rhythm disorders.

1133094053
Cardiac Bioelectric Therapy: Mechanisms and Practical Implications
Pacing and defibrillation have become the leading therapeutic treatments of heart rhythm disorders, including bradycardia and tachycardia. The success of these therapies is largely due to centuries of scientific inquiry into the fundamental mechanisms of bioelectric phenomena in the heart. History of successful development of bioelectric therapies includes development of experimental and theoretical methodologies, novel bioengineering approaches, and state-of-the-art clinical implantable device therapies.

The purpose of this book is to present a uniform thematic collection of reviews written by the leading basic and applied scientists working in basic bioengineering research laboratories, who have contributed to the development of current understanding of the fundamental mechanisms of pacing and electrophysiology, and who are at the leading edge of further developments in electrotherapy.

The book will start from the historic overview of the subject, including the development of the pacemaker and defibrillator, evolution of theories of cardiac arrhythmias and experimental methods used in the field over the centuries. Leading experts in the field will write these chapters. The second part of the book will focus on rigorous treatment of the fundamental theory of interaction between electric field and cardiac cell, tissue, and organ. Chapters will be written by top notch scientists, who made critically important contributions to the development of these theories. Part 3 will provide summary of several decades of research involving electrode recordings and multielectrode mapping of ventricular fibrillation and defibrillation in humans and animal models of arrhythmias. Part 4 will present new insights into defibrillation gained due to the advent of optical imaging technology, which permitted to map defibrillation without overwhelming shock-induced artifacts present in electrode recordings. Part 5 will provide rigorous overview of themethodologies, which made research of physiological and engineering aspects of electrotherapy possible. And finally, part 6 will present possible future of implantable devices and electrotherapy in the treatment of cardiac rhythm disorders.

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Cardiac Bioelectric Therapy: Mechanisms and Practical Implications

Cardiac Bioelectric Therapy: Mechanisms and Practical Implications

Cardiac Bioelectric Therapy: Mechanisms and Practical Implications

Cardiac Bioelectric Therapy: Mechanisms and Practical Implications

Paperback(Softcover reprint of the original 1st ed. 2009)

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Overview

Pacing and defibrillation have become the leading therapeutic treatments of heart rhythm disorders, including bradycardia and tachycardia. The success of these therapies is largely due to centuries of scientific inquiry into the fundamental mechanisms of bioelectric phenomena in the heart. History of successful development of bioelectric therapies includes development of experimental and theoretical methodologies, novel bioengineering approaches, and state-of-the-art clinical implantable device therapies.

The purpose of this book is to present a uniform thematic collection of reviews written by the leading basic and applied scientists working in basic bioengineering research laboratories, who have contributed to the development of current understanding of the fundamental mechanisms of pacing and electrophysiology, and who are at the leading edge of further developments in electrotherapy.

The book will start from the historic overview of the subject, including the development of the pacemaker and defibrillator, evolution of theories of cardiac arrhythmias and experimental methods used in the field over the centuries. Leading experts in the field will write these chapters. The second part of the book will focus on rigorous treatment of the fundamental theory of interaction between electric field and cardiac cell, tissue, and organ. Chapters will be written by top notch scientists, who made critically important contributions to the development of these theories. Part 3 will provide summary of several decades of research involving electrode recordings and multielectrode mapping of ventricular fibrillation and defibrillation in humans and animal models of arrhythmias. Part 4 will present new insights into defibrillation gained due to the advent of optical imaging technology, which permitted to map defibrillation without overwhelming shock-induced artifacts present in electrode recordings. Part 5 will provide rigorous overview of themethodologies, which made research of physiological and engineering aspects of electrotherapy possible. And finally, part 6 will present possible future of implantable devices and electrotherapy in the treatment of cardiac rhythm disorders.


Product Details

ISBN-13: 9781489979124
Publisher: Springer US
Publication date: 08/23/2016
Edition description: Softcover reprint of the original 1st ed. 2009
Pages: 634
Product dimensions: 7.01(w) x 10.00(h) x (d)

About the Author

Igor R. Efimov, Ph.D.
Alisann and Terry Collins Professor of Biomedical Engineering
Director, Cardiovascular Engineering Laboratory
The George Washington University
Washington, DC
USA

Fu Siong Ng, M.D., Ph.D.
Clinical Senior Lecturer in Cardiac Electrophysiology
Consultant Cardiologist & Cardiac Electrophysiologist
National Heart & Lung Institute
Imperial College London
London
United Kingdom

Jacob Laughner, PhD
Research and Development
Philips Electrophysiology
Cambridge, MA
USA

Table of Contents

Part I. History.- Chapter 1. History of Cardiac Pacing.- Chapter 2. History of Defibrillation.- Chapter 3. History of Cardiac Mapping.- Chapter 4. History of Optical Mapping.- Part II. Theory of Electric Stimulation and Defibrillation.- Chapter 5. The Bidomain Theory of Pacing.- Chapter 6. Bidomain Theory of Defibrillation.- Chapter 7. The Generalized Activating Function.- Part III. Electrode Mapping and Defibrillation.- Chapter 8. Extracellular Mapping of Arrhythmia.- Chapter 9. Critical Points and the Upper Limit of Vulnerability for Defibrillation.- Chapter 10. Inverse Potential Methods of Cardiac Mapping.- Chapter 11. Monophasic Action Potential.- Part IV. Optical Mapping of Stimulation and Defibrillation.- Chapter 12. Mechanisms of Isolated Cell Stimulation.- Chapter 13. The Role of Microscopic Tissue Structure in Defibrillation.- Chapter 14. Virtual Electrode Theory of Pacing.- Chapter 15. The Virtual Electrode Hypothesis of Defibrillation.- Chapter 16. Simulataneous Optical andElectrical Recording.- Chapter 17. Advanced 3D Optical Mapping.- Chapter 18. Electromechanical Optical Mapping Methods.- Part V. Methodology.- Chapter 19. The Bidomain Model of Cardiac Tissue: From Microscale to Macroscale.- Chapter 20. Newer Models of Cardiac Tissue.- Chapter 21. The Role of Electroporation.- Chapter 22. RF Versus Cryo Ablation.- Chapter 23. Electroanatomical Mapping.- Part VI. Implications for Implantable Devices.- Chapter 24. Lessons for the Clinical Implant.- Chapter 25. Resonance and Feedback Strategies for Low-Voltage Defibrillation.- Chapter 26. Pacing Control of Local Cardiac Dynamics.- Chapter 27. Advanced Methods for Assessing the Stability and Control of Alternans.- Chapter 28. The Future of Implantable Defibrillator.- Chapter 29. Lessons Learnt from Implantable Cardioverter -Defibrillators Recordings.- Part VII. Novel Arrhythmia Therapies.- Chapter 30. Optogenetic Control of Arrhythmias.- Chapter 31. Subcutaneous Defibrillation.- Chapter 32. Future High-Resolution Mapping.- Chapter 33. Conformal Electronics Therapy for Defibrillation.- Chapter 34. Multistage Defibrillation Therapy.- Chapter 35. Implantable Cardioverter Defibrillator to Cardiac Implantable Electronic Device.- Chapter 36. Leadless Pacing.- Chapter 37. Direct His-bundle Pacing.- Chapter 38. Artificial Intelligence/Machine Learning/Deep Learning.- Chapter 39. Wearable Devices for Ambulatory Cardiac and Respiratory Monitoring.
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