Casarett & Doull's Essentials of Toxicology, Fourth Edition / Edition 4

by Curtis D. Klaassen, John B. Watkins

Overview

Develop a strong foundation in the concepts and principles of toxicology with this concise and accessible resource

Doody's Core Titles for 2023!

For more than 25 years, Casarett & Doull’s Toxicology: The Basics of Poison has set the standard for providing thorough, academic, and authoritative information in clear and engaging ways. Distilling the major principles and concepts from that renowned text, Casarett & Doull’s Essentials of Toxicology delivers an accessible and highly readable introduction to the science and clinical field of medical toxicology. The book reflects the expertise of more than 60 renowned contributors.

Presented in full-color, this new edition builds on the wide success of previous editions, with extensive updates that make the book more clinically relevant to students and beginners in toxicology, pharmacology, pharmacy, and environmental sciences. Chapter-ending self-assessment Q&As and other features make the learning process more effective and efficient.

Casarett and Doull’s Essentials of Toxicology is organized into seven units:

• General Principles of Toxicology
• Disposition of Toxicants
• Non-organ-directed Toxicity
• Target Organ Toxicity
• Toxic Agents
• Environmental Toxicology
• Applications of Toxicology

Succinct, yet comprehensive, the text covers essential principles, toxicokinetics, how toxic effects are passed on to succeeding generations, how each body system responds to poisons, and the specific effects of a wide range of toxic agents—from pesticides to radiation.

Product Details

ISBN-13:	9781260452297
Publisher:	McGraw Hill LLC
Publication date:	02/23/2021
Edition description:	4th ed.
Pages:	640
Sales rank:	297,375
Product dimensions:	8.60(w) x 10.80(h) x 1.20(d)

About the Author

Curtis D. Klaassen, PhD, was distinguished Professor and Chair, Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center. (Retired.)

John B. Watkins, III, PhD, is Professor Emeritus of Pharmacology and Toxicology, Director of the Medical Sciences Program, Indiana University School of Medicine.

John B. Watkins, PhD, Professor of Pharmacology and Toxicology, Medical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana

Table of Contents

Contributors vii

Preface xii

Unit 1 General Principles of Toxicology 1

1 The Evolving Journey of Toxicology: A Historical Glimpse Philip Wexler Antoinette N. Hayes 1

2 Principles of Toxicology Lauren M. Aleksunes David L. Eaton 11

3 Mechanisms of Toxicity Lois D. Lehman-McKeeman 33

4 Risk Assessment Elaine M. Faustman 69

Unit 2 Disposition of Toxicants 83

5 Absorption, Distribution, and Excretion of Toxicants Angela L. Slitt 83

6 Biotransformation of Xenobiotics Andrew Parkinson Brian W. Ogilvie David B. Buckley Faraz Kazmi Oliver Parkinson 101

7 Toxicokinetics Kannan Krishnan 139

Unit 3 Non-Organ-Directed Toxicity 153

8 Chemical Carcinogenesis James E. Klaunig Zemin Wang 153

9 Genetic Toxicology Joanna Klapacz B. Bhaskar Gollapudi 169

10 Developmental Toxicology John M. Rogers 183

Unit 4 Target Organ Toxicity 199

11 Toxic Responses of the Blood Martyn T. Smith Cliona M. McHale 199

12 Toxic Responses of the Immune System Barbara L.F. Kaplan Courtney E. W. Sulentic Helen G. Haggerty Michael P. Holsapple Norbert E. Kaminski 215

13 Toxic Responses of the Liver Robert A. Roth Hartmut Jaeschke James P. Luyendyk 241

14 Toxic Responses of the Kidney Rick G. Schnellmann 263

15 Toxic Responses of the Respiratory System George D. Leikauf 277

16 Toxic Responses of the Nervous System Virginia C. Moser Michael Aschner Jason R. Richardson Aaron B. Bowman Rudy J. Richardson 297

17 Toxic Responses of the Cornea, Retina, and Central Visual System Donald A. Fox William K. Boyes 313

18 Toxic Responses of the Heart and Vascular System Matthew J. Campen 329

19 Toxic Responses of the Skin Donald V. Belsito 353

20 Toxic Responses of the Endocrine System Patricia B. Hoyer Jodi A. Flaws 369

21 Toxic Responses of the Reproductive System Paul M.D. Foster L. Earl Gray Jr. 383

Unit 5 Environmental Toxicology 399

22 Toxic Effects of Pesticides Lucio G. Costa 399

23 Toxic Effects of Metals Alexander C. Ufelle Aaron Barchowsky 417

24 Toxic Effects of Solvents and Vapors James V. Bruckner S. Satheesh Anand D. Alan Warren 437

25 Toxic Effects of Radiation and Radioactive Materials David G. Hoel 453

26 Toxic Effects of Plants and Animals John B. Watkins, III 463

27 Food Toxicology: Fundamental and Regulatory Aspects Supratim Choudhuri 483

28 Toxic Effects of Calories Martin J.J. Ronis Kartik Shankar Thomas M. Badger 503

29 Nanoparticle Toxicology David B. Warheit Günter Oherdörster Agnes B. Kane Scott C. Brown Rebecca D. Klaper Robert H. Hurt 515

Unit 6 Environmental Toxicology 531

30 Ecotoxicology Richard T. Di Giulio Michael C. Newman 531

31 Air Pollution Daniel L. Costa Terry Gordon 543

Unit 7 Applications of Toxicology 561

32 Analytical and Forensic Toxicology Bruce A. Goldberger Dayong Lee Diana G. Wilkins 561

33 Clinical Toxicology Louis R. Cantilena Jr. 569

34 Occupational Toxicology Peter S. Thorne 581

Answers to Chapter Questions 593

Index 597

Editorial Reviews

Reviewer: Rosemary M Caron, PhD, MPH (MGH Institute of Health Professions)
Description: This fourth edition is a distilled text based on the prominent Casarett & Doull's Toxicology: The Basic Science of Poisons, 9th edition, Klaassen (McGraw Hill, 2019), which has served as the standard resource for toxicology for more than quarter of a century. The fourth edition, published in 2021, succeeds the third edition, published in 2015, and includes 34 chapters written by 70 contributing authors, color exhibits, and seven units that progress from general toxicology principles to target organ toxicity and applications of toxicology. The book's narrative is comprehensive and written for a science-oriented audience with a chapter outline and key points included at the beginning of each chapter and multiple choice questions at the end of each chapter. There are no citations in the narrative of the text and a bibliography is provided in place of a reference section at the end of each chapter. The book's website could not be accessed via www.LangeTextbooks.com (on the back cover); rather, the online resources were available at accesspharmacy.mhmedical.com for a subscription fee or via one's institutional access.
Purpose: This fourth edition offers extensive updates over the previous version, thus making the book more relevant to students from a clinical standpoint. This book condenses the toxicological principles and concepts presented in the prominent Casarett & Doull's Toxicology: The Basic Science of Poisons and applies the science of toxicology to anatomy, physiology, and biochemistry to describe the mechanisms of toxicant action on the human body. This edition is available in print and online (via a fee-based subscription service).
Audience: The intended audience for this book, as stated by the authors, include undergraduate and graduate students in toxicology, as well as students from other disciplines. I would also include students from health and basic science disciplines, as well as healthcare practitioners, occupational safety officers, and scientists interested in toxicology principles and the effects of toxic agents on specific target organs. The book is edited by two renowned academicians. The first is Dr. Curtis Klaassen, a retired distinguished professor and chair at the University of Kansas School of Medicine who also serves as editor for the renowned Casarett & Doull's Toxicology: The Basic Science of Poisons. Dr. John Watkins III, a professor emeritus at the Indiana University School of Medicine, serves as the second editor. Seventy prominent academicians, consultants, and industry experts in the field of toxicology author the chapters.
Features: The fourth edition is well organized into seven units covering general principles of toxicology, disposition of toxicants, non-organ-directed toxicity, toxic agents, environmental toxicology, and applications of toxicology. The chapters are organized into sections which provide in-depth narrative and colored exhibits (i.e., tables and figures). An outline of the chapter and key points initiate each chapter. Each chapter concludes with 10 multiple choice questions for which the answers are provided at the end of the book prior to the index. A glossary and acronym or abbreviation listing is absent but would be useful for the student who is new to this field. The book is sparse on helpful study tools including notes, study questions other than multiple choice, and further reading recommendations. A bibliography is provided for each chapter, but a reference section is absent as citations are not found in the narrative. The book is aesthetically pleasing to peruse as the color art contributes to inviting the reader to explore the chapter content. The book reflects the current state of knowledge about toxicology and its application with a clinical emphasis and could also serve as a valuable reference for students, practitioners, and scientists. The print version of the book is accompanied by a website where an online version of the book is available for a subscription fee at accesspharmacy.mhmedical.com. The functionality in the paid service includes jumping to different sections of a chapter, downloading the chapter, citing information, sharing the chapter via social media, and searching the book. There appear to be interactive study tools (e.g., flashcards, review questions, cases, multimedia, etc.) in the subscribed online platform, which may also be accessible via one's institutional membership. The online platform is rather limited without a paid subscription.
Assessment: This fourth edition is a consolidated text based on the prominent Casarett & Doull's Toxicology: The Basic Science of Poisons. The book is intended for those needing to understand the mechanisms by which toxic agents affect the body. A certain level of prior knowledge in the areas of anatomy, physiology, and biochemistry is assumed. The book can serve as both a text for a student of toxicology, as well as a reference for those practicing in the field. From a student perspective, the book is limited in study tools in the print version with more options seemingly available in the fee-based online version. The book is a well-developed adaptation of the more comprehensive and longer Casarett & Doull's Toxicology: The Basic Science of Poisons and serves as a manageable resource for those needing to learn more about the clinical manifestation and implications of toxic agents on the human body.

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