Design and Analysis of Clinical Experiments / Edition 1

by Joseph L. Fleiss

Overview

First published in 1986, this unique reference to clinical experimentation remains just as relevant today. Focusing on the principles of design and analysis of studies on human subjects, this book utilizes and integrates both modern and classical designs. Coverage is limited to experimental comparisons of treatments, or in other words, clinical studies in which treatments are assigned to subjects at random.

Product Details

ISBN-13:	9780471349914
Publisher:	Wiley
Publication date:	02/22/1999
Series:	Wiley Classics Library , #73
Edition description:	Wiley Classics Lib ed.
Pages:	448
Product dimensions:	6.06(w) x 9.04(h) x 0.81(d)

About the Author

JOSEPH L. FLEISS, PhD, headed the Division of Biostatistics at Columbia University's Mailman School of Public Health in New York for seventeen years. He is also the author of a previous book, The Design and Analysis of Clinical Experiments, also from Wiley.

BRUCE LEVIN, PhD, is the current Chair of the Department of Biostatistics at Columbia University. His research interests include categorical data analysis, clinical trials, sequential experimentation, statistics in law, and reproductive epidemiology.

MYUNGHEE CHO PAIK, PhD, is a professor in the Department of Biostatistics at Columbia University's Mailman School of Public Health.

Table of Contents

Reliability of Measurement.

Simple Linear Regression Analysis.

The Parallel Groups Design.

Special Cases of the Parallel Groups Study.

Blocking to Control for Prognostic Variables.

Stratification to Control for Prognostic Variables.

Analysis of Covariance and the Study of Change.

Repeated Measurements Studies.

Latin and Greco-Latin Squares.

The Crossover Study.

Balanced Incomplete Block Designs.

Factorial Experiments.

Split-Plot Designs and Confounding.

Appendix.

Indexes.

Editorial Reviews

A guide for clinical investigators and biostatisticians in biomedical research centers and the pharmaceutical industry who are responsible for designing clinical experiments and for analyzing resulting data. Real examples from such specialties as cardiology, dentistry, gerontology, neurology, pediatrics, and psychiatry are used to illustrate designs and their analyses. Includes numerical and algebraic chapter problems. Can be used as a text for a second-year, graduate-level course. First published in 1986 by John Wiley & Sons. Annotation c. by Book News, Inc., Portland, Or.

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