Dissipation and Control in Microscopic Nonequilibrium Systems
This thesis establishes a multifaceted extension of the deterministic control framework that has been a workhorse of nonequilibrium statistical mechanics, to shastic, discrete, and autonomous control mechanisms. This facilitates the application of ideas from shastic thermodynamics to the understanding of molecular machines in nanotechnology and in living things. It also gives a scale on which to evaluate the nonequilibrium energetic efficiency of molecular machines, guidelines for designing effective synthetic machines, and a perspective on the engineering principles that govern efficient microscopic energy transduction far from equilibrium. The thesis also documents the author’s design, analysis, and interpretation of the first experimental demonstration of the utility of this generally applicable method for designing energetically-efficient control in biomolecules. Prools designed using this framework systematically reduced dissipation, when compared to naive prools, in DNA hairpins across a wide range of experimental unfolding speeds and between sequences with wildly different physical characteristics.
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Dissipation and Control in Microscopic Nonequilibrium Systems
This thesis establishes a multifaceted extension of the deterministic control framework that has been a workhorse of nonequilibrium statistical mechanics, to shastic, discrete, and autonomous control mechanisms. This facilitates the application of ideas from shastic thermodynamics to the understanding of molecular machines in nanotechnology and in living things. It also gives a scale on which to evaluate the nonequilibrium energetic efficiency of molecular machines, guidelines for designing effective synthetic machines, and a perspective on the engineering principles that govern efficient microscopic energy transduction far from equilibrium. The thesis also documents the author’s design, analysis, and interpretation of the first experimental demonstration of the utility of this generally applicable method for designing energetically-efficient control in biomolecules. Prools designed using this framework systematically reduced dissipation, when compared to naive prools, in DNA hairpins across a wide range of experimental unfolding speeds and between sequences with wildly different physical characteristics.
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Dissipation and Control in Microscopic Nonequilibrium Systems

Dissipation and Control in Microscopic Nonequilibrium Systems

by Steven J. Large
Dissipation and Control in Microscopic Nonequilibrium Systems

Dissipation and Control in Microscopic Nonequilibrium Systems

by Steven J. Large

Paperback(1st ed. 2021)

$199.99 
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Overview

This thesis establishes a multifaceted extension of the deterministic control framework that has been a workhorse of nonequilibrium statistical mechanics, to shastic, discrete, and autonomous control mechanisms. This facilitates the application of ideas from shastic thermodynamics to the understanding of molecular machines in nanotechnology and in living things. It also gives a scale on which to evaluate the nonequilibrium energetic efficiency of molecular machines, guidelines for designing effective synthetic machines, and a perspective on the engineering principles that govern efficient microscopic energy transduction far from equilibrium. The thesis also documents the author’s design, analysis, and interpretation of the first experimental demonstration of the utility of this generally applicable method for designing energetically-efficient control in biomolecules. Prools designed using this framework systematically reduced dissipation, when compared to naive prools, in DNA hairpins across a wide range of experimental unfolding speeds and between sequences with wildly different physical characteristics.

Product Details

ISBN-13: 9783030858278
Publisher: Springer International Publishing
Publication date: 10/24/2021
Series: Springer Theses
Edition description: 1st ed. 2021
Pages: 236
Product dimensions: 6.10(w) x 9.25(h) x (d)

About the Author

Dr. Steven Large grew up in Victoria, Canada, and received his undergraduate honours degree in Nanoscience in 2015 from the University of Guelph in Ontario, Canada. He then completed his PhD in Physics at Simon Fraser University in Vancouver, Canada, defending his thesis in December 2020 under the supervision of Prof. David Sivak. Currently, Dr. Large works as a Data Scientist with Viewpoint Investment Partners, in Calgary, Alberta, using quantitative analysis methods and machine learning techniques to develop robust long-term financial investment strategies.

Table of Contents

Chapter 1. Introduction.- Chapter 2. Theoretical background.- Chapter 3. DNA hairpins I: Calculating the generalized friction.- Chapter 4. DNA Hairpins II: reducing dissipation in nonequilibrium prools.- Chapter 5. DNA Hairpins III: robustness, variability, and conclusions.- Chapter 6. Shastic control in microscopic nonequilibrium systems.- Chapter 7. Optimal discrete control: minimizing dissipation in discretely driven systems.- Chapter 8. On dissipation bounds: discrete shastic control of nonequilibrium systems.- Chapter 9. Free energy transduction within autonomous systems.- Chapter 10. Hidden excess power and autonomous Maxwell demons in strongly coupled nonequilibrium systems.- Chapter 11. Conclusions and outlook.

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