Drugs in Inflammation

Drugs in Inflammation

Paperback(Softcover reprint of the original 1st ed. 1991)

Use Standard Shipping. For guaranteed delivery by December 24, use Express or Expedited Shipping.

Product Details

ISBN-13: 9783034874076
Publisher: Birkh�user Basel
Publication date: 11/17/2012
Series: Agents and Actions Supplements , #32
Edition description: Softcover reprint of the original 1st ed. 1991
Pages: 260
Product dimensions: 6.69(w) x 9.61(h) x 0.02(d)

Table of Contents

Reducing the Side-Effects of Anti-Inflammatory Drugs.- Towards safer nonsteroidal anti-inflammatory drugs.- Developing nonsteroidal anti-inflammatory drugs (NSAIDs) with decreased gastrointestinal (GI) toxicity.- Anti-inflammatory efficacy and gastrointestinal irritancy: comparative 1 month repeat oral dose studies in the rat with nabumetone, ibuprofen and diclofenac.- A new anti-inflammatory agent (EGIS-5645) without gastrointestinal side-effect.- Antipyretic activity of tebufelone (NE-11740) in man.- Steroid-saving potency of nonsteroidal anti-inflammatory agents — a reevaluation with the new agent CGP 28238 in rat inflammatory models.- A biochemical investigation of auranofin nephrotoxicity by high field proton nuclear magnetic resonance (NMR) spectroscopy.- Influence of an intravenous dose of aurothiomalate on the status of low-molecular-mass endogenous metabolites in blood plasma: a proton nuclear magnetic resonance (NMR) study.- Influence of disodium aurothiomalate on the activities of xanthine dehydrogenase and xanthine oxidase in endothelial cells.- Application of a novel 1:1 gold (I)-chromophoric thiolate complex as a spectrophotometric probe for the thiol-exchange reactions of anti-arthritic gold drugs in biological fluids.- Effects of auranofin on endothelium dependent contractions in isolated rat aoria.- New Approaches to Pain Relief.- Electrophysiological mechanisms in inflammatory pain.- Molecular base of acetylcholine and morphine analgesia.- Prostaglandin (PG) modulation of bradykinin-induced hyperalgesia and oedema in the guinea-pig paw — effects of PGD2, PGE2 and PGI2.- Analgetic activity of SK&F 105809, a dual inhibitor of arachidonic acid metabolism.- Pharmacological profile of flupirtine, a novel centrally acting, non-opioid analgesic drug.- The pharmacological profile of aceclofenac, a new nonsteroidal anti-inflammatory and analgesic drug.- New Treatments for Bone and Cartilage Loss in Rheumatoid Arthritis.- Molecular basis of intracellular interactions in relation to bone and joint disease.- The role of proteinases in cartilage destruction.- Recognition of IL1-activated chondrocytes in porcine articular cartilage.- In vivo evidence for a key role of IL-1 in cartilage destruction in experimental arthritis.- An anti-CD4 antibody for treatment of chronic inflammatory arthritis.- Modulation of splenic lymphocyte activities by a new hypoxanthine derivative (ST 789) in immunosuppressed mice.- The newly developed neutrophil oxidative burst antagonist apocynin inhibits joint-swelling in rat collagen arthritis.- Auto-immune spondylodiscitis associated with collagen induced arthritis in rats: high field MRI findings.- Influence of muramyl dipeptide on established experimental arthritis in rats.- Selective inhibition by magnosalin and magnoshinin, compounds from “shin-I” (Flos magnoliae), of adjuvant-induced angiogenesis and granuloma formation in the mouse pouch.- Drug Modulation of Cytokine Production.- Cellular and molecular mechanisms of cytokine networking.- Anti-inflammatory properties of E5090, a novel orally active inhibitor of IL-1 generation.- A novel inhibitor of IL-1 generation, E5090: in vitro inhibitory effects on the generation of IL-1 by human monocytes.- A novel inhibitor of IL-1 generation, E5090: in vivo inhibitory effects on the generation of IL-1-like factor and on granuloma formation in an air-pouch model.- Lack of adjuvanticity of human recombinant interleukin-lß in collagen induced arthritis in rats.- Influence of azelastine on IL-1ß generation in vitro and IL-lß-induced effect in vivo.

Customer Reviews

Most Helpful Customer Reviews

See All Customer Reviews