Dynamics of Proteins and Nucleic Acids
This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity. The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods that are likely to be useful in the computer-aided design of drugs, enzymes and other molecules. A variety of theoretical and experimental studies is described and these are critically analyzed to provide a comprehensive picture of dynamic aspects of biomolecular structure and function. The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers), biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology.
1100939192
Dynamics of Proteins and Nucleic Acids
This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity. The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods that are likely to be useful in the computer-aided design of drugs, enzymes and other molecules. A variety of theoretical and experimental studies is described and these are critically analyzed to provide a comprehensive picture of dynamic aspects of biomolecular structure and function. The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers), biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology.
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Dynamics of Proteins and Nucleic Acids

Dynamics of Proteins and Nucleic Acids

Dynamics of Proteins and Nucleic Acids

Dynamics of Proteins and Nucleic Acids

Overview

This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity. The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods that are likely to be useful in the computer-aided design of drugs, enzymes and other molecules. A variety of theoretical and experimental studies is described and these are critically analyzed to provide a comprehensive picture of dynamic aspects of biomolecular structure and function. The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers), biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology.

Product Details

ISBN-13: 9780521356527
Publisher: Cambridge University Press
Publication date: 04/29/1988
Edition description: New Edition
Pages: 248
Product dimensions: 5.98(w) x 9.02(h) x 0.55(d)

Table of Contents

Preface; 1. Introduction; 2. Structure of proteins, nucleic acids, and their solvent surroundings; 3. Dynamics of proteins, nucleic acids, and their solvent surroundings; 4. Theoretical methods; 5. Short time dynamics; 6. Local structural transitions; 7. Global structural changes; 8. Dynamics of molecular associations; 9. Recent developments and future directions; Appendices; References; Index.
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