Eicosanoids: From Biotechnology to Therapeutic Applications

by Giancarlo C. Folco (Editor), Bengt Samuelsson (Editor), Jacques Maclouf (Editor), G.P Velo (Editor)

Overview

Proceedings of a NATO ASI held in Erice, Italy, April 27-May 1, 1995.

Product Details

ISBN-13:	9780306452864
Publisher:	Springer US
Publication date:	04/30/1996
Series:	NATO Science Series A: , #283
Edition description:	1996
Pages:	208
Product dimensions:	6.14(w) x 9.21(h) x 0.36(d)

Table of Contents

1. Leukotriene A4 Hydrolase: A Key Enzyme in the Biosynthesis of Leukotriene B4.- 2. Lipoxygenases of Mice and Men.- 3. The Physiological and Therapeutic Significance of Separate Pathways for Prostaglandin Synthesis.- 4. Assessment of Pharmacological Inhibition of PGH-Synthases in Man.- 5. Metabolism of Eicosanoids in Mammalian Cells.- 6. New Approach in Immunometric Assays.- 7. Transcellular Biosynthesis of Arachidonic Acid Metabolites: From in Vitro Investigations to in Vivo Reality.- 8. Polymorphonuclear-Endothelial Cell Interactions and the Control of Coronary Vasculature.- 9. PGHS-2 Dependent Formation of 8-Epi PGF2? by Human Monocytes.- 10. Platelet-Activating Factor Regulates Events at the Vascular Wall.- 11. Studies of Isoprostane Biosynthesis in Man.- 12. N-3 Fatty Acids. Antithromboxane Activity. Effects on Redox Status of Blood Cells.- 13. Receptors and Second Messengers for cys-Leukotrienes.- 14. Prostanoid Receptors: Classification, Characterisation and Therapeutic Relevance.- 15. Microvascular Actions and Interactions of Eicosanoids and Histamine in Inflammation.- 16. Leukotriene Antagonists and Synthetase Inhibitors; Clinical Applications in the Treatment of Bronchial Asthma.- 17. PGI2 and Its Analogs: From Pharmacology to Therapeutic Applications.- 18. Leukotriene Synthesis (FLAP) Inhibition: Biochemistry and Pharmacology of Bay X 1005.

Editorial Reviews

Among the 18 topics are the lipoxygenases of mice and men, the assessment of pharmacological inhibition of PGH-synthases in man, polymorphonuclear-endothelial cell interactions and the control of coronary vasculature, the clinical application of leukotrience antagonists and synthetase inhibitors in the treatment of bronchial asthma, microvascular actions and interactions of eicosanoids and histamine in inflammation, and the transcellular biosynthesis of arachidonic acid metabolites. No preface or introduction. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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