Pub. Date:
Taylor & Francis
Engineering Genetic Circuits / Edition 1

Engineering Genetic Circuits / Edition 1

by Chris J. Myers, Adam Arkin
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Product Details

ISBN-13: 9781420083248
Publisher: Taylor & Francis
Publication date: 07/14/2009
Series: Chapman & Hall/CRC Mathematical and Computational Biology Series
Edition description: New Edition
Pages: 306
Product dimensions: 6.30(w) x 9.40(h) x 0.80(d)

About the Author

Chris J. Myers is a professor in the Department of Electrical and Computer Engineering at the University of Utah. A co-inventor on four patents and author of more than 80 technical papers and the textbook Asynchronous Circuit Design, Dr. Myers received an NSF Fellowship in 1991 and an NSF CAREER award in 1996. His research interests include formal verification, asynchronous circuit design, and the analysis and design of genetic regulatory circuits.

Table of Contents

An Engineer’s Guide to Genetic Circuits

Chemical Reactions



Cells and Their Structure

Genetic Circuits


Phage lambda: A Simple Genetic Circuit

Learning Models

Experimental Methods

Experimental Data

Cluster Analysis

Learning Bayesian Networks

Learning Causal Networks

Experimental Design

Differential Equation Analysis

A Classical Chemical Kinetic Model

Differential Equation Simulation

Qualitative ODE Analysis

Spatial Methods

Stochastic Analysis

A Stochastic Chemical Kinetic Model

The Chemical Master Equation

Gillespie’s Stochastic Simulation Algorithm

Gibson/Bruck’s Next Reaction Method


Relationship to Reaction Rate Equations

Stochastic Petri-Nets

Phage lambda Decision Circuit Example

Spatial Gillespie

Reaction-Based Abstraction

Irrelevant Node Elimination

Enzymatic Approximations

Operator Site Reduction

Statistical Thermodynamical Model

Dimerization Reduction

Phage lambda Decision Circuit Example

Stoichiometry Amplification

Logical Abstraction

Logical Encoding

Piecewise Models

Stochastic Finite-State Machines

Markov Chain Analysis

Qualitative Logical Models

Genetic Circuit Design

Assembly of Genetic Circuits

Combinational Logic Gates

PoPS Gates

Sequential Logic Circuits

Future Challenges

Solutions to Selected Problems




Sources and Problems appear at the end of each chapter.

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