Enteric Infections and Immunity / Edition 1

by Lois J. Paradise, Mauro Bendinelli, Herman Friedman

Overview

As we approach the end of this millennium, enteric diseases remain important public health problems. In many parts of the world, sanitary measures have advanced little over the last century, although some of the governments in those areas are striving to improve facilities for sanitation and to educate their people in proper handling of food, water, sewage, and other modes of transmission of pathogenic microbes. Even in highly developed countries, outbreaks of diarrheal diseases occur today. Globally, the annual morbidity from enteric infections is estimated at several billion and deaths at several million per year. In this volume, descriptions of some of these diseases, of immunity that results from them, of clinical studies that promote understanding of individual and community immunity, of molecular factors of pathogenesis, and/or of advances in vaccine development have been provided by leading researchers. At present, the application of molecular methods is enhancing the identification of protective antigens of many microorganisms. In addition, new methods for design and delivery of vac­ cines are being devised. Perhaps then more effective tools for reducing at least some of these diseases will be available within the next decade. Lois J. Paradise Herman Friedman Mauro Bendinelli vii Contents Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xv LOIS J. PARADISE 1. Indigenous Microorganisms as a Host Defense 1 KENNETH H. WILSON 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. Composition of Intestinal Biota. . . . . . . . . . . . . . . . . . . . . . . . 2 3. Molecular Approaches to Determine Composition of the Biota . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . 3 4. Role of the Host in Determining the Composition of the Biota . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Product Details

ISBN-13:	9780306452420
Publisher:	Springer US
Publication date:	05/31/1996
Series:	Infectious Agents and Pathogenesis
Edition description:	1996
Pages:	272
Product dimensions:	6.10(w) x 9.25(h) x 0.03(d)

About the Author

Paradise, Lois J. (Univ of South Florida); Bendinelli, Mauro (Univ of Pisa); Friedman, Herman (Univ of South Florida)

The contributors represent the specialties of parasitology, infectious disease, microbiology and immunology, internal medicine, and geographic medicine. Most are from academic medical centers in the U.S. and Canada. Institutions prominently represented include McGill Univ, Temple Univ, Univ of Alabama at Birmingham, Harvard Univ, Univ of Maryland, and Duke.

Table of Contents

1. Indigenous Microorganisms as a Host Defense.- 2. Mucosal Immunity: Molecular and Cellular Aspects of Immune Protection to Enteric Infections.- 3. Vibrio cholerae: Molecular Pathogenesis, Immune Response, and Vaccine Development.- 4. Immunity to Salmonella Infections.- 5. Shigella Infection.- 6. Escherichia coli.- 7. Molecular Pathogenesis of Campylobacter jejuni Enteritis.- 8. Clostridia and Bacteroides in Enteric Infections.- 9. The Staphylococcal Toxins in Human Disease.- 10. Immunological Aspects of Viral Gastroenteritis.- 11. Immunopathogenesis of Entamoeba histolytica.- 12. Giardia Infections.- 13. The Immune Regulation of Intestinal Helminthiases.

Editorial Reviews

Reviewer: John A. Robinson, MD (Loyola University Stritch School of Medicine)
Description: This is a somewhat specialized book on enteric infectious diseases and the interesting nuances of host responses to them.
Purpose: The latter is a poorly explored area and one of the last immunological frontiers.
Audience: It is recommended to internists, fellows in infectious disease, public health officials, epidemiologists, and some microbiologists.
Features: The book starts with several dense and rather difficult-to-read chapters; however, subsequent chapters on specific diseases (especially shigella and vibrio cholera) are well done. Several of the chapters summarize quite well the current status of mucosal responses and their implications to various enteric organisms. Unfortunately, the exciting new demonstration of phage-mediated virulence in the vibrio occurred after the book's publication deadline. It would have been exciting to read discussions by these experts in a multiauthored book on the implications of this discovery with relationship to developing a vaccine for the disease. There is more than the usual unevenness in some of the chapters, especially in the breadth of the literature cited and helpful illustrations.
Assessment: This book serves as a concentrated point of reference for a globally important group of infections.

Doody's Review Service

‘This book serves as a concentrated point of reference for a globally important group of infections.'
Doody's

From the Publisher

2 Stars from Doody

This is a somewhat specialized book on enteric infectious diseases and the interesting nuances of host responses to them. The latter is a poorly explored area and one of the last immunological frontiers. It is recommended to internists, fellows in infectious disease, public health officials, epidemiologists, and some microbiologists. The book starts with several dense and rather difficult-to-read chapters; however, subsequent chapters on specific diseases (especially shigella and vibrio cholera) are well done. Several of the chapters summarize quite well the current status of mucosal responses and their implications to various enteric organisms. Unfortunately, the exciting new demonstration of phage-mediated virulence in the vibrio occurred after the book's publication deadline. It would have been exciting to read discussions by these experts in a multiauthored book on the implications of this discovery with relationship to developing a vaccine for the disease. There is more than the usual unevenness in some of the chapters, especially in the breadth of the literature cited and helpful illustrations. This book serves as a concentrated point of reference for a globally important group of infections.

John A. Robinson

Twenty-five researchers deliver descriptions of enteric diseases which globally account for several million deaths per year, focusing on immunities formed from these diseases, clinical studies of community and individual immunity, molecular factors of pathogenesis, and vaccine development. Discussions of specific infections include Vibrio cholerae, Salmonella, Shigella, Escherichia coli, clostridia and bacteroides in enteric infections, staphylococcal toxins, viral gastroenteritis, and Giardia. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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