Essential Cell Biology (Hardback)

by Bruce Alberts, Karen Hopkin, Alexander D. Johnson, David Morgan

Overview

Essential Cell Biology, Second Edition contains basic, core knowledge about how cells work. It has a proven track record in providing students with a conceptual and accessible grounding in cell biology. The text and figures have been prepared to be easy-to-follow, accurate, clear and engaging for the introductory student. Each section follows logically from the previous one, telling a story, rather than being a collection of facts. Questions integrated throughout each chapter encourage the reader to pause, think about what they have read, and attempt to apply the new knowledge in ways that test their understanding. Based on user feedback, the Second Edition now offers increased coverage of genetics and more experimental background. It is completely up-to-date.

Product Details

ISBN-13:	9780393679533
Publisher:	Norton, W. W. & Company, Inc.
Publication date:	07/28/2019
Edition description:	New Edition
Product dimensions:	6.00(w) x 1.25(h) x 9.00(d)

About the Author

Bruce Alberts received his PhD from Harvard University and is Professor of Biochemistry and Biophysics at the University of California, San Francisco. For 12 years, he served as President of the U.S. National Academy of Sciences (1993-2005).

Dennis Bray received his PhD from Massachusetts Institute of Technology and is currently an active emeritus professor at University of Cambridge. In 2006 he was awarded the Microsoft European Science Award.

Karen Hopkin received her PhD in biochemistry from the Albert Einstein College of Medicine and is a science writer in Somerville, Massachusetts. She is a regular columnist for The Scientistand a contributor to Scientific American's daily podcast, "60-Second Science."

Alexander Johnson received his PhD from Harvard University and is Professor of Microbiology and Immunology and Director of the Biochemistry, Cell Biology, Genetics, and Developmental Biology Graduate Program at the University of California, San Francisco.

Julian Lewis received his DPhil from the University of Oxford and was a Principal Scientist at the London Research Institute of Cancer Research UK.

Martin Raff received his MD from McGill University and is at the Medical Research Council Laboratory for Molecular Cell Biology and the Biology Department at University College London.

Keith Roberts received his PhD from the University of Cambridge and is Emeritus Professor at the University of East Anglia, Norwich.

Peter Walter received his PhD from The Rockefeller University in New York and is Professor and Chairman of the Department of Biochemistry and Biophysics at the University of California, San Francisco, and an Investigator of the Howard Hughes Medical Institute.

Table of Contents

Chapter 1	Introduction to Cells	1
Panel 1-1	Light and electron microscopy	8
Panel 1-2	Cells: the principal features of animal, plant, and bacterial cells	25
	How We Know: Life's common mechanisms	30
Chapter 2	Chemical Components of Cells	39
	How We Know: What are macromolecules?	60
Panel 2-1	Chemical bonds and groups	66
Panel 2-2	The chemical properties of water	68
Panel 2-3	An outline of some of the types of sugars	70
Panel 2-4	Fatty acids and other lipids	72
Panel 2-5	The 20 amino acids found in proteins	74
Panel 2-6	A survey of the nucleotides	76
Panel 2-7	The principal types of weak noncovalent bonds	78
Chapter 3	Energy, Catalysis, and Biosynthesis	83
Panel 3-1	Free energy and biological reactions	96
	How We Know: Using kinetics to model and manipulate metabolic pathways	103
Chapter 4	Protein Structure and Function	119
Panel 4-1	A few examples of some general protein functions	120
	How We Know: Probing protein structure	129
Panel 4-2	Four different ways of depicting a small protein	132
Panel 4-3	Cell breakage and initial fractionation of cell extracts	160
Panel 4-4	Protein separation by chromatography	162
Panel 4-5	Protein separation by electrophoresis	163
Panel 4-6	Making and using antibodies	164
Chapter 5	DNA and Chromosomes	169
	How We Know: Genes are made of DNA	172
Chapter 6	DNA Replication, Repair, and Recombination	195
	How We Know: Finding replication origins	198
Chapter 7	From DNA to Protein: How Cells Read the Genome	229
	How We Know: Cracking the genetic code	246
Chapter 8	Control of Gene Expression	267
	How We Know: Gene regulation--the story of eve	282
Chapter 9	How Genes and Genomes Evolve	293
	How We Know: Counting genes	314
Chapter 10	Manipulating Genes and Cells	323
	How We Know: Sequencing the human genome	334
Chapter 11	Membrane Structure	365
	How We Know: Measuring membrane flow	384
Chapter 12	Membrane Transport	389
	How We Know: Squid reveal secrets of membrane excitability	414
Chapter 13	How Cells Obtain Energy from Food	427
Panel 13-1	Details of the 10 steps of glycolysis	432
	How We Know: Unraveling the citric acid cycle	442
Panel 13-2	The complete citric acid cycle	450
Chapter 14	Energy Generation in Mitochondria and Chloroplasts	453
	How We Know: How chemiosmotic coupling drives ATP synthesis	460
Panel 14-1	Redox potentials	471
Chapter 15	Intracellular Compartments and Transport	497
	How We Know: Tracking protein and vesicle transport	520
Chapter 16	Cell Communication	533
	How We Know: Untangling cell signaling pathways	561
Chapter 17	Cytoskeleton	573
	How We Know: Pursuing motor proteins	586
Chapter 18	Cell-Cycle Control and Cell Death	611
	How We Know: Discovery of cyclins and Cdks	618
Chapter 19	Cell Division	637
Panel 19-1	The principal stages of M phase in an animal cell	642
	How We Know: Building the mitotic spindle	646
Chapter 20	Genetics, Meiosis, and the Molecular Basis of Heredity	659
	How We Know: Reading genetic linkage maps	682
Panel 20-1	Some essentials of classical genetics	685
Chapter 21	Tissues and Cancer	697
Panel 21-1	The cell types and tissues from which higher plants are constructed	700
	How We Know: Making sense of the genes that are critical for cancer	734
	Answers to Questions	A:1
	Glossary	G:1
	Index	I:1

Editorial Reviews

This book fills a critical niche in the pedagogical process of introducing cell biology and does an excellent job in reaching its objective.
—December 2004, volume 79

The Quarterly Review of Biology

An excellent example of designing a textbook for undergraduates and non-biology majors. It is clear, well illustrated, conversational in tone and enjoyable to read and browse through.
—October 2004

E-Streams

College and university professors who have used the previous editions of ECB will be pleased with the new edition. The format and organization are retained but have been infused with fresh images and updated material. It's as if a trusted old friend has come back from an extended vacation with a bright new look and a refreshed attitude. The reader is at once comfortable with and excited by the changes. New users of the textbook will find it accessible and approachable at the professorial and student levels . . . .I highly recommend it to all CBE-Life Sciences Education readers who are also classroom educators.

CBE-Life Sciences Education

PRAISE FOR THE PREVIOUS EDITION
“Enthralls the reader….Core concepts are explained from first principles in a manner that is lucid and unambiguous....That the authors have assembled a seminal cell biology textbook cannot be disputed….really ought to be an intrinsic part of every bioscience undergraduate’s essential reading.”
- The Biochemist

"…the language and terminology used by the authors remain focused at a level appropriate to and accessible by undergraduate students….New users of the textbook will find it accessible and approachable….The instructor resources remain a valuable addition….I highly recommend it to all.”
- CBE-Life Sciences Education

"This attractive, accessible, visually oriented text covers the fundamentals of cell biology required to understand biomedical and broader issues that affect students' lives."
- SciTech Book News

“Essential Cell Biology, fourth edition, provides an up-to-date introduction to the fundamental concepts of cell biology as well as rapidly growing fields such as stem cell biology, development, and cancer....This book is ideal for students taking an introductory cell or molecular biology course, yet is also suitable for individuals looking to simply refresh their understanding of some of the basics of cell biology....Students will gain a broad understanding of biological processes from the latest edition of Essential Cell Biology, which will also help them as they advance to more specialized topics of biology and biomedical research.” –Yale Journal of Biology and Medicine

From the Publisher