Pub. Date:
Oxford University Press
Estrogens and Memory: Basic Research and Clinical Implications

Estrogens and Memory: Basic Research and Clinical Implications

by Karyn M. FrickKaryn M. Frick
Current price is , Original price is $130.0. You

Temporarily Out of Stock Online

Please check back later for updated availability.


Estrogens are key modulators of brain regions that mediate learning and memory formation. This regulation has significant translational implications, as estrogens contribute to age-related memory decline and dementia, emotional disorders, addiction, and recovery from brain injury. Although the importance of estrogens for memory formation has been well accepted within the behavioral neuroendocrinology community, it has yet to be fully appreciated by neuroscientists outside of the discipline.

Recent National Institutes of Health policies on the inclusion of sex as a biological variable in grant applications will force thousands of researchers to consider hormonal regulation of memory for the first time. However, the majority of these researchers are not trained endocrinologists, and no previous monograph comprehensively encompasses the breadth of basic and clinical research on this subject. Thus, this book provides a vital resource for non-endocrinologists and endocrinologists alike.

Estrogens and Memory: Basic Research and Clinical Implications provides a compendium of cutting-edge basic and clinical research describing the ways in which estrogens regulate memory in a variety of species. Chapters are written by leading experts whose work is on the forefront of this exciting field. Three fundamental discussions focus on: effects of estrogens on the hippocampus and other brain regions central to memory, effects of estrogens on memory and related cognitive processes throughout the lifespan, and translational implications of estrogenic regulation of memory for aging and disease.

Product Details

ISBN-13: 9780190645908
Publisher: Oxford University Press
Publication date: 01/28/2020
Series: Oxford Series in Behavioral Neuroendocrinology
Pages: 516
Product dimensions: 10.10(w) x 7.20(h) x 1.30(d)

About the Author

Dr. Frick is a behavioral neuroscientist and neuroendocrinologist. She is a Professor of Psychology at the University of Wisconsin-Milwaukee, and an Adjunct Professor of Pharmacology and Experimental Therapeutics at the Medical College of Wisconsin.

Table of Contents

Karyn M. Frick

Part I Estrogen effects on the hippocampus and related brain regions

1. Estrogen receptor distribution in the hippocampus and prefrontal cortex
Annelyn Torres-Reveron, Wayne G. Brake, and Teresa A. Milner

2. Estrogen receptors at the membrane: Interactions with metabotropic glutamate receptors and caveolin proteins regulated through palmitoylation
Katherine R. Tonn, Paul G. Mermelstein, and John Meitzen

3. Rapid effects of estradiol on dendritic spines and synaptic plasticity in the male and female hippocampus
Asami Kato, Gen Murakami, Yasushi Hojo, Sigeo Horie and Suguru Kawato

4. Rapid modulation of spinogenesis by estradiol in the neocortex: An emerging role for GPER?
Deepak P. Srivastava, Katherine J. Sellers, Peter D. Evans

5. Estrogenic regulation of synaptic actin proteins and plasticity
Enik A. Kram r

6. Hippocampal synaptic stability and plasticity: The role of hippocampus-derived estradiol
Gabriele M. Rune

7. Estrogenic regulation of glia and neuroinflammation
Andrea Crespo-Castrillo, Maria Angeles Arevalo, Luis M. Garcia-Segura, and Natalia Yanguas-Cas s

Part II Estrogenic regulation of memory and related cognitive processes throughout the lifespan

8. Molecular mechanisms underlying rapid effects of estradiol on memory consolidation
Karyn M. Frick, Jaekyoon Kim, Wendy Koss, and Jennifer J. Tuscher

9. Estrogenic regulation of spatial memory in songbirds
David J. Bailey and Colin J. Saldanha

10. Estrogenic regulation of recognition memory and spinogenesis
Victoria N. Luine and Maya Frankfurt

11. Who are you and what do you know? Estrogenic regulation of social recognition and social learning
Paul A.S. Shepard, Talya Kuun, Pietro Paletta, and Elena Choleris

12. Estrogens have their ups and downs: A multiple memory systems approach to the bidirectional effects of estrogens on learning strategy
Donna L. Korol

13. Puberty: Effects on the prefrontal cortex and cognitive behavior
Janice M. Juraska

14. Ovarian hormones, cognition, and reproductive aging: Applications and implications for translating preclinical endocrine brain research to the clinic
Alesia A. Prakapenka, Veronica Pena, Heather A. Bimonte-Nelson

15. Estrogenic regulation of hippocampal neurogenesis throughout the lifespan
Shunya Yagi, Rand Mahmoud, Wansu Qiu, Paula Duarte-Guterman, and Liisa A.M. Galea

16. Effects of estradiol on basal forebrain cholinergic neurons and their impact on cognitive performance and age-related cognitive decline
Robert B. Gibbs

17. Estrogenic regulation of synaptic health and cognition in aging rhesus monkeys
Johanna L. Crimins, Yuko Hara, John H. Morrison

Part III Translational implications of estrogenic regulation of memory for aging and disease

18. Hormone therapy in postmenopausal women: The Women's Health Initiative Memory Study and its continuing impact on research and practice
Ira Driscoll, Stephen R. Rapp, Karen C. Johnson, Mark A. Espeland

19. Estrogen treatment in Alzheimer's disease: Translational implications of estrogenic regulation of memory for aging and disease
Kelly N. Morgan and Carey E. Gleason

20. Effects of dietary estrogens on dementia
Shelina Kassam, Mira Soni, Eef Hogervorst

21. Oral contraceptive effects on cognition
Soniya Assudani Patel, Courtney McQuade, Robert S. Astur

22. Effects of SERMS and antiestrogens on cognition in women with breast cancer
Jeffrey D. Blaustein

23. Estrogen neuroprotection and anti-inflammation actions in the hippocampus
Roshni D. Thakkar, Ruimin Wang, Gangadhara R. Sareddy, Ratna K. Vadlamundi, and Darrell W. Brann

24. Estrogenic regulation of neuroprotection and inflammation in ischemic stroke and aging
Farida Sohrabji, Shameena Bake, Amutha Selvamani

25. Estradiol and fear generalization: Implications for anxiety disorders
Aaron M. Jasnow, Jordan M. Adkins, and Joseph F. Lynch III

26. Role of estrogens in addiction-related learning
Hanna Yousuf

Part IV Conclusions and Future Directions

27. Moving forward: A vision for future research on estrogenic regulation of memory
Karyn M. Frick


Customer Reviews