Evidence-Based Pediatric Oncology

by Ross Pinkerton (Editor), A. G. Shankar (Editor), Katherine Matthay (Editor)

Overview

The new and updated edition of the renowned reference for pediatric oncologists

This groundbreaking text on the management of childhood cancers covers most tumor types occurring in children and young adults and provides reviews of randomized trials with commentaries on the optimum treatments for childhood cancer.

Updated with evidence from the latest published reviews—and even more clinically focused than previous editions— Evidence-Based Pediatric Oncology, Third Edition places an emphasis on application of the trial findings. With increased coverage of the area of supportive care for pediatric cancer patients, each chapter opens with an expert commentary on the key clinical issues followed by a summary of trial findings.

Evidence-Based Pediatric Oncology, Third Edition:

• Presents evidence for the best treatment of children and adolescents with cancer

• Includes commentaries from the world’s leading experts for every topic discussed

• Is internationally relevant thanks to contributions from the UK, US, Canada and Australia

• Places greater emphasis on supportive care and features a new extended section on antibiotic and antifungal treatments

Based on information gathered from randomized trials performed after the release of the Second Edition, readers will find Evidence-Based Pediatric Oncology to be an important resource for all those treating young people with cancer.

Product Details

ISBN-13:	9780470659649
Publisher:	Wiley
Publication date:	05/28/2013
Series:	Evidence-Based Medicine
Edition description:	3rd ed.
Pages:	294
Product dimensions:	18.00(w) x 9.60(h) x 0.70(d)

About the Author

Edited by
Ross Pinkerton, MB, BCh, BaO, MD, Executive Director, Division of Oncology, Royal Children’s Hospital, Children’s Health Queensland, Brisbane, QLD, Australia

Ananth Shankar, MD, FRCPCH, Consultant in Paediatric and Adolescent Oncology, University College
London Hospitals NHS Foundation Trust, London, UK

Katherine K. Matthay, BA, MD, Mildred V. Strouss Professor of Translational Oncology, Director, Pediatric Hematology-Oncology, Department of Pediatrics, UCSF School of Medicine and UCSF Benioff Children’s Hospital, San Francisco, CA, USA

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Table of Contents

List of contributors, vii

Preface, ix

List of abbreviations, x

About the companion website, xv

Part 1: Solid tumors

1 Rhabdomyosarcoma, 3
Katherine K. Matthay

(Commentary by Meriel Jenney)

2 Osteosarcoma, 14
Katherine K. Matthay

(Commentary by Maria Michelagnoli)

3 Ewing sarcoma, 25
Katherine K. Matthay

(Commentary by Steven G. DuBois)

4 Wilms tumor, 34
Ananth Shankar

(Commentary by Kathy Pritchard-Jones)

5 Neuroblastoma, 47
Katherine K. Matthay

(Commentary by Katherine K. Matthay)

6 Hepatoblastoma, 58
Ross Pinkerton

(Commentary by Penelope Brock)

7 Malignant germ cell tumors, 65
Ross Pinkerton

(Commentary by Ross Pinkerton)

8 Medulloblastoma, 69
Ross Pinkerton

(Commentary by Eric Bouffet)

9 Glioma, 81
Ross Pinkerton

(Commentary by Joann L. Ater)

10 Non-Hodgkin lymphoma, 88
Ross Pinkerton

(Commentary by Ross Pinkerton)

11 Hodgkin lymphoma, 105
Ross Pinkerton

(Commentary by Cindy L. Schwartz)

Part 2: Leukemia

Section 1: Acute myeloid leukemia 12 Acute myeloid leukemia commentary, 119
Robert J. Arceci

13 Remission induction in acute myeloid leukemia, 126
Ananth Shankar

14 Acute myeloid leukemia consolidation, 135
Ananth Shankar

15 Maintenance treatment in acute myeloid leukemia, 137
Ananth Shankar

16 Autologous bone marrow transplantation in acute myeloid leukemia, 141
Ananth Shankar

17 Acute myeloid leukemia: miscellaneous, 144
Ananth Shankar

Section 2: Childhood lymphoblastic leukemia

18 Childhood lymphoblastic leukemia commentary, 146
Vaskar Saha

19 Remission induction in childhood lymphoblastic leukemia, 154
Ananth Shankar

20 Central nervous system-directed therapy in childhood lymphoblastic leukemia, 168
Ananth Shankar

21 Maintenance treatment in childhood lymphoblastic leukemia, 180
Ananth Shankar

22 Relapsed childhood lymphoblastic leukemia, 198
Ananth Shankar

23 Postinduction therapy in adolescents and young adults with acute lymphoblastic leukemia, 204
Ananth Shankar

Part 3: Supportive care in pediatric oncology

24 Colony-stimulating factors, 209
Ananth Shankar

(Commentary by Victoria Grandage)

25 Cardioprotection in pediatric oncology, 230
Ananth Shankar

(Commentary by Gill A. Levitt)

26 Infections in pediatric and adolescent oncology, 243
Ananth Shankar and Sara Stoneham

(Commentary by Julia E. Clark)

Index, 269

What People are Saying About This

From the Publisher

"[T]he book has an international feel and the writers comment on American and European views. Perspective, hard facts and evidence based is the strength of this book, a heavyweight in his clas." Bulletin of the Royal College of Pathologists

“This book must be in the library of any practicing pediatric oncologist … authors do not follow the classic format … but instead focus on the presentation of important … trials.”
Doodys Book Reviews

Editorial Reviews

"This reference provides a useful "one-stop shop" for some of the key data from RCTs in paediatric oncology. The study summaries are short enough to be easily digested while having sufficient detail to allow readers to glean key facts." (EBM, February 2009)

"The book provides good material for readers to get up-to-date with the latest clinical trials in the field of pediatric oncology … .The information given is up-to-date and is presented in a simple and easy to understand manner" (Sultan Qaboos University Medical Journal, December 2007)

"[T]he book has an international feel and the writers comment on American and European views. Perspective, hard facts and evidence based is the strength of this book, a heavyweight in his clas." (Bulletin of the Royal College of Pathologists)

“This book must be in the library of any practicing pediatric oncologist … authors do not follow the classic format … but instead focus on the presentation of important … trials.” (Doodys Book Reviews)

From the Publisher