Fidelity and Quality Control in Gene Expression

by Assen Marintchev

Overview

The goal of this volume is to provide a comprehensive mechanistic and quantitative view of the processes that mediate or influence the quality control in translation. In addition to discussing processes with direct contribution to translation fidelity, such as aminoacylation of tRNAs and translation elongation itself, special attention is given to other processes with impact on quality control: detection and elimination of defective mRNAs, recycling and translation re-initiation, mRNA editing, and translational recoding through programmed frame-shifting.

Product Details

ISBN-13:	9780123864970
Publisher:	Elsevier Science
Publication date:	01/27/2012
Series:	Advances in Protein Chemistry and Structural Biology , #86
Pages:	272
Product dimensions:	6.00(w) x 9.00(h) x (d)

Table of Contents

1. Quality Control in Aminoacyl-tRNA Synthesis: Its Role in Translational FidelitySrujana S. Yadavalli and Michael Ibba
2. Termination and Post-Termination Events in Eukaryotic Translation

Richard J. Jackson, Christopher U.T. Hellen and Tatyana V. Pestova

3. Quality Control of mRNA Decoding on the Bacterial Ribosome

Marina V. Rodnina

4. Control of Gene Expression by Translational Recoding

Jonathan D. Dinman

5. The tmRNA Ribosome Rescue System

Brian D. Janssen and Christopher S. Hayes

6. Posttranscriptional Recoding by RNA EditingStefan Maas

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From the Publisher

Provides a comprehensive mechanistic and quantitative view of the processes that mediate or influence the quality control in translation.