Firestein & Kelley's Textbook of Rheumatology, 2-Volume Set

by Gary S. Firestein MD, Ralph C. Budd MD, Sherine E Gabriel MD, MSc, Iain B. McInnes PhD, FRCP, FRSE, FMedSci, James R. O'Dell MD

Overview

Through 10 outstanding editions, Kelley & Firestein’s Textbook of Rheumatology has provided authoritative, in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. The 11th Edition of this classic text continues this tradition of excellence, while keeping you abreast of recent advances in genetics and the microbiome, new therapies such as biologics and biosimilars, and other rapid changes in the field. It provides comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, in a user-friendly, full color reference.

• Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes—including key data on therapeutic outcomes to better inform clinical decision making.
• Includes new chapters on Innate Lymphoid Cells and Natural Killer Cells, Pathogenesis of Inflammasome Mediated Diseases, Bisphosphonates, Ultrasound Evaluation of the Musculoskeletal System, and Evaluation of Monoarticular and Polyarticular Arthritis.
• Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs.
• Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editor Dr. Gary Koretzky, specialist in immunology and rheumatology.
• Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints.
• Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Product Details

ISBN-13:	9780323639200
Publisher:	Elsevier Health Sciences
Publication date:	07/28/2020
Edition description:	11th ed.
Pages:	2400
Product dimensions:	8.50(w) x 10.88(h) x (d)

About the Author

Gary Firestein, MD, is a board-certified rheumatologist who diagnoses and treats patients with autoimmune conditions as well as diseases of the joints, muscles and bones. A professor at UC San Diego School of Medicine, Dr. Firestein is distinguished for his research and serves as director of the Altman Clinical and Translational Research Institute and the senior associate vice chancellor for health sciences. Dr. Firestein's research interest focuses on the pathogenesis and treatment of rheumatoid arthritis.
Dr. Firestein is the recipient of many awards and honors, including the Arthritis Foundation's Jane Wyman Humanitarian Award in 2010 for his contributions to rheumatology; the Arthritis Foundation Lee C. Howley Sr. Prize for Arthritis Research; and the American College of Rheumatology Distinguished Investigator Award. He has been elected to the American Society for Clinical Investigation and the Association of American Physicians. He has served as an editor for the Textbook of Rheumatology for since the 7th edition (2004).

Iain McInnes is Director of the Institute of Infection, Immunity and Inflammation at the University of Glasgow, UK. He has extensive experience in leading multicenter programs nationally and internationally. He is Director of the Scottish MRC Clinical Pharmacology and Pathology Clinical PhD Training Program, Chief Investigator for the Scottish Early RA Cohort (SERA) and the related SMS-IC biomarker discovery program (PROMISERA), and chief investigator of numerous global phase II and III clinical trials of novel immune therapies. He has served as member or chair of numerous national grant-funding panels and as chair of several European League Against Rheumatism (EULAR) scientific committees – he is now Treasurer and President Elect of EULAR serving on its Steering Committee. He is formerly Chairman of the Foundation for European Rheumatology Research (Foreum) Scientific Committee and leads the EULAR-supported European Roadmap Program that is defining the research agenda for rheumatology for the next decade.

James R. O’Dell, MD is the Stokes Shackleford Professor of Internal Medicine, Vice-Chairman of Internal Medicine and Chief of the Division of Rheumatology at the University of Nebraska Medical Center (UNMC) in Omaha. Dr. O’Dell founded and has directed the Rheumatoid Arthritis Investigational Network (RAIN) for the last 25 years. Dr. O’Dell is the PI of the large multinational RA research study based at the VA through their cooperative studies program. Dr. O’Dell has published extensively, mostly in the area of rheumatoid arthritis. He has presented frequently at national and international meetings and has more than 100 published articles in top-level rheumatology journals. He has served on numerous American College of Rheumatology (ACR) committees over the last 20 years, including time on both the ACR and REF BOD, as well as a two-year term as President of the Research and Education Foundation of the ACR and was President of the College (2011-2012). Additionally, he is Editor-in-Chief of Up To Date for Rheumatology.

Gary Koretzky, MD, PhD is Professor of Medicine at Weill Cornell Graduate School. Dr. Koretzky’s research aims to better understand the signal transduction events that occur following engagement of the T cell antigen receptor. He has been continuously funded by the National Institutes of Health since establishing his independent research group, as the laboratory has expanded its interests to study more globally the molecular events important for immune cell development, differentiation and function. Dr. Koretzky has published more than 200 research articles. He is a past President of the American Society of Clinical Investigation (2000) and Councilor of the Association of American Physicians (2008-2012), is a Fellow of the American Association for the Advancement of Science (2004), a member of the Institute of Medicine of the National Academies (2008), a Fellow of the American Academy of Arts & Sciences (2012) and serves as the Editor-in-Chief of Immunological Reviews (2002-present).

Table of Contents

PART 1 Structure and Function of Bone, Joints, and Connective Tissue
1 Developmental Biology, Organization, and Function of the Synovial Joints
2 Synovium
3 Cartilage and Chondrocytes
4 Development and Biology of Bone
5 Muscle Anatomy, Physiology, and Biochemistry
6 Biomechanics
7 Regenerative Medicine and Tissue Engineering
8 Proteinases and Matrix Degradation

PART 2 Cells Involved in Autoimmune Diseases and Inflammation
9 Dendritic Cells
10 Mononuclear Phagocytes
11 Neutrophils
12 T Lymphocytes
13 B Cells
14 Fibroblasts andFibroblast-like Synoviocytes
15 Mast Cells and Basophils
16 Innate Lymphoid Cells and Natural Killer Cells
17 Platelets and Megakaryocytes

PART 3 Effector Mechanisms in Autoimmunity and Inflammation
18 Principles of Signaling
19 Innate Immunity
20 Adaptive Immunity
21 Immune Tolerance and Autoimmunity
22 Pre-clinical Autoimmunity
23 The Microbiome in Rheumatic Diseases
24 Genetics of Rheumatic Diseases
25 Epigenetics of Rheumatic Diseases
26 Complement System
27 Prostaglandins, Leukotrienes, and Related Compounds
28 Angiogenesis
29 Cytokines and Chemokines
30 Neuronal Mechanisms of Pain and Inflammation

PART 4 Broad Issues in the Approach to Rheumatic Disease
31 Clinical Research Methods in the Rheumatic Diseases
32 Epidemiology and Impact of Rheumatic Diseases
33 Assessment of Health Outcomes
34 Biomarkers in Rheumatology
35 Occupational, Environmental, and Recreational Musculoskeletal Disorders
36 Cardiovascular Risk in Inflammatory Rheumatic Disease
37 Cancer Risk in Rheumatic Diseases
38 Occupational Therapy, Physical Therapy, and Rehabilitation
39 General Principles of Pregnancy and Rheumatic Disease: Pre-pregnancy Assessment

PART 5 Evaluation of Generalized and Localized Symptoms
40 History and Physical Examination of the Musculoskeletal System
41 Ultrasound in Rheumatology
42 Evaluation of Monoarticular and Polyarticular Arthritis
43 Skin and Rheumatic Diseases
44 The Eye and Rheumatic Diseases

PART 6 Differential Diagnosis of Regional and Diffuse Musculoskeletal Pain
45 Neck Pain
46 Shoulder Pain
47 Low Back Pain
48 Hip and Knee Pain
49 Foot and Ankle Pain
50 Hand and Wrist Pain
51 Temporomandibular Joint Disorders
52 Fibromyalgia

PART 7 Diagnostic Tests and Procedures in Rheumatic Diseases
53 Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology
54 Arthrocentesis and Injection of Joints and Soft Tissues
55 Anti-nuclear Antibodies
56 Autoantibodies in Rheumatoid Arthritis
57 Acute Phase Reactants
58 Imaging in Rheumatic Diseases

PART 8 Pharmacology of Anti-rheumatic Drugs
59 Therapeutic Targeting of Prostanoids
60 Glucocorticoid Therapy
61 Traditional DMARDs: Methotrexate, Leflunomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies
62 Immunosuppressive Drugs
63 Anti-cytokine Biologics
64 Cell-Targeted Biologics and Emerging Targets: Rituximab, Abatacept, and Other Biologics
65 Janus Kinase and Other Intra-cellular Targets
66 Urate-Lowering Therapy
67 Bisphosphonates
68 Analgesic Agents in Rheumatic Disease
69 Nutrition and Rheumatic Diseases

PART 9 Rheumatoid Arthritis and Sjögren’s Syndrome
70 Etiology of Rheumatoid Arthritis
71 Pathogenesis of Rheumatoid Arthritis
72 Clinical Features of Rheumatoid Arthritis
73 Treatment of Rheumatoid Arthritis
74 Sjögren’s Syndrome

PART 10 Spondyloarthritis
75 Classification and Epidemiology of Spondyloarthritis
76 Axial Spondyloarthritis
77 Reactive Arthritis
78 Psoriatic Arthritis
79 Inflammatory Bowel Disease–Associated Arthritis and Other Enteropathic Arthropathies

PART 11 Systemic Lupus Erythematosus and Related Syndromes
80 Etiology and Pathogenesis of Systemic Lupus Erythematosus
81 Clinical Features of Systemic Lupus Erythematosus
82 Treatment of Systemic Lupus Erythematosus
83 Antiphospholipid Syndrome

PART 12 Systemic Sclerosis, Inflammatory Myopathies, and Overlap Syndromes
84 Etiology and Pathogenesis of Systemic Sclerosis
85 Clinical Features and Treatment of Scleroderma
86 Inflammatory Diseases of Muscle and Other Myopathies
87 Overlap Syndromes

PART 13 Vasculitis
88 Classification and Epidemiology of Systemic Vasculitis
89 Giant Cell Arteritis, Polymyalgia Rheumatica, and Takayasu’s Arteritis
90 Anti-neutrophil Cytoplasmic Antibody–Associated Vasculitis
91 Polyarteritis Nodosa
92 Immune Complex–Mediated Small Vessel Vasculitis
93 Primary Central Nervous System Vasculitis
94 Behçet’s Disease

PART 14 Crystal-Induced and Inflammasome-Mediated Inflammation
95 Pathogenesis of Inflammasome-Mediated Diseases
96 Etiology and Pathogenesis of Hyperuricemia and Gout
97 Clinical Features and Treatment of Gout
98 Calcium Crystal Disease: Calcium Pyrophosphate Deposition Disease and Basic Calcium Phosphate-Associated Syndromes
99 Familial and Nonfamilial Autoinflammatory Syndromes

PART 15 Cartilage, Bone, and Heritable Connective Tissue Disorders
100 Etiology and Pathogenesis of Osteoarthritis
101 Clinical Features of Osteoarthritis
102 Treatment of Osteoarthritis
103 Metabolic Bone Disease
104 Proliferative Bone Diseases
105 Osteonecrosis
106 Relapsing Polychondritis
107 Heritable Diseases of Connective Tissues

PART 16 Rheumatic Diseases of Childhood
108 Etiology and Pathogenesis of Juvenile Idiopathic Arthritis
109 Clinical Features and Treatment of Juvenile Idiopathic Arthritis
110 Childhood-Onset Systemic Lupus Erythematosus, Drug-Induced Lupus in Children, and Neonatal Lupus
111 Juvenile Dermatomyositis, Scleroderma, and Vasculitis

PART 17 Infections and Rheumatic Disease
112 Bacterial Arthritis
113 Lyme Disease
114 Mycobacterial Infections of Bones and Joints
115 Fungal Infections of Bones and Joints
116 Rheumatic Manifestations of Human Immunodeficiency Virus Infection
117 Viral Arthritis
118 Rheumatic Fever and Post-streptococcal Arthritis
119 COVID-19 and Rheumatic Disease
120 Vaccination in Rheumatic Disease

PART 18 Arthritis Accompanying Systemic Disease
121 Amyloidosis
122 Sarcoidosis
123 Hemochromatosis
124 Hemophilic Arthropathy
125 Rheumatic Manifestations of Hemoglobinopathies
126 IgG4-Related Disease
127 Arthritis Accompanying Endocrine and Metabolic Disorders
128 Rheumatic Paraneoplastic Syndromes and Malignancies With Rheumatic Manifestations
129 Tumors and Tumor-like Lesions of Joints and Related Structures
130 Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer

What People are Saying About This

From the Publisher

Authoritative, comprehensive coverage of rheumatology from the classic, bestselling text in the field

Editorial Reviews

Doody's Core Titles® 2021 Essential Purchase

From the Publisher