Genome Structure and Function: From Chromosomes Characterization to Genes Technology

by C. Nicolini (Editor)

Overview

Proceedings of the NATO Advanced Study Institute on Genome Structure and Function, held in Marciana Marina, Elba, Italy, 13-23 June 1996

Product Details

ISBN-13:	9780792345657
Publisher:	Springer Netherlands
Publication date:	05/31/1997
Series:	NATO Science Partnership Subseries: 3 , #31
Edition description:	1997
Pages:	331
Product dimensions:	6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

Preface. Genome Structure - Function from Nuclei to Chromosomes and Nucleosomes; G. Nicolini. Chromosomal DNA Loops and Domain Organization of the Eukaryotic Genome; S.V. Razin. Interrelationships between Nuclear Structure and Transcriptional Control of Cell Cycle and Tissue-Specific Genes; G.S. Stein, et al. Transcriptional Regulation in a Chromatin Environment; A.P. Wolffe. Nucleosome and Chromatin Structures and Functions; S. Pennings, E.M. Bradbury. Chromatin Structure and Gene Regulation by Steroid Hormones; M. Beato, et al. The Nuclear PI Cycle: Its Relevance to Nuclear Structure and Function; R.S. Gilmour, et al. The Role of Structure in Complexes between the p53 DNA Binding Domain and DNA Response Elements; A.K. Nagaich, et al. Genetics of Human Astrocytic Tumors; W.K. Cavenee. Tumor Progression and Metastasis; G.P. Georgiev, et al. The Future of DNA Sequencing: After the Human Genome Project; C.R. Cantor, et al. Large-Scale Chromatin Structure; A.S. Belmont. Plant Gene Technology; I.L. Bagyan, et al. The 5'-Untranslated Leaders of BSMV RNAgamma and PVX Coat Protein mRNA as Translational Enhancers in Tobacco Protoplasts; I.L. Bagyan, et al. Subject Index.

Editorial Reviews

This book is a compilation of 15 reviews written by researchers who participated in a NATO Advanced Study Institute course in June 1996. The course focused on ""Genome Structure and Function"" and covered many aspects of DNA structure, from the higher order structure of chromosomes and chromatin to the characterization of specific genes and promoters. A variety of research methods are represented from biophysical methods to cell and molecular biology. A few chapters focus on biotechnology, particularly transgenic plants. The purpose was to provide insight into the many aspects of genome study and to the current state of research in the field. The book is written for molecular and cellular biologists, most likely researchers in related areas, but also graduate students looking for information above the level of textbooks. Several chapters are written by well-known researchers who have written numerous reviews. These chapters tend to be broad in content, giving a good overview. Other chapters are very restricted in focus, for instance the characterization of viral translational enhancers for use in transgenic plants. The illustrations are black and white and of poor quality: even bar graphs are not reproduced well. The references in most cases are relevant and up-to-date. The book does not have a uniform level of presentation. The chapters that are general are similar to reviews by the same authors that are published elsewhere and readily available; the other chapters do not add sufficient general information to make the articles useful. The objective of the book is laudable, but the particular mix of reviews does not make the book a worthwhile purchase.

Carolyn Jahn

Papers from a June meeting describe DNA structure and gene expression of control of cell function and cell cycle progression, covering both structural and functional aspects, and give insight into modern problems of genome study and recent achievements in related fields of molecular and cell biology, genetic engineering, biochemistry and biophysics, oncology, and biotechnology. Emphasis is on DNA structure and function in interphase and metaphase chromosomes as revealed in biophysical and biochemical studies conducted on a range of cell systems. Other subjects include industrial utilization of recombinant DNA in agriculture and health, and novel or non-conventional instrumentation for the study of DNA, such as scanning probe microscopy, synchrotron radiation, and biosensors. Annotation c. by Book News, Inc., Portland, Or.

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