Glycomicrobiology

by Ronald J. Doyle (Editor)

Overview

At one time, it was thought that only eukaryotic cells could glycosylate proteins. Two major kinds of glycoproteins were recognized in animal cells, consisting of O- or N-linked saccharides. The O-linked saccharides were derived from gly- sylation of threonine or serine, whereas N-linked saccharides were derived from asparagine. In recent years, numerous glycoproteins have been found in bacteria, many of which do not possess typical animal cell glycosylation patterns. One of the purposes of this volume is to provide a thorough discussion of c- bohydrate-peptide linkages in bacteria. Interestingly, though Braun's lipoprotein of some gram-negative bacteria was discovered nearly three decades ago, it was never considered to be a glycoprotein, even though it possessed a peptide-car- hydrate linkage. In the past few years, it is clear that even gram-positive cells can covalently bind proteins to their cell walls. The role of carbohydrates in the rec- nition of animal cells by bacteria is now well established. Saccharide-specific - hesins have been sequenced, cloned and employed as potential vaccines. Furth- more, carbohydrate receptors on animal cells for bacterial adhesins have been identified and characterized. Another purpose for this volume is to provide a forum for new information on adhesin-receptor complexes involving bacterial pathogens. There now is a b- geoning literature on carbohydrate structure, function, and molecular biology in bacteria. The role of carbohydrates in biotechnology and biomass utilization has become important in the past decade due to new methods for carbohydrate det- tion and the cloning of biosynthetic and degradative enzymes.

Product Details

ISBN-13:	9781475786569
Publisher:	Springer US
Publication date:	04/20/2013
Edition description:	2002
Pages:	549
Product dimensions:	5.98(w) x 9.02(h) x 0.05(d)

Table of Contents

Preface. Non-S-Layer Glycoproteins: A Review; S. Moens. Glycans in Meningococcal Pathogenesis and the Enigma of the Molecular Decorations of Neisserial Pili; M. Virji. Polypeptide Linkage to Bacterial Cell Envelope Glycopolymers; H.F. Jenkinson. Surface Layer (S-Layer) Glycoproteins of Bacteria and Archaea; P. Messner, C. Schäffer. Assembly Pathways for Biosynthesis of A-band and B-band Lipopolysaccharde in Pseudomonas aeruginosa; L.L. Burrows, et al. Interactions of Bacterial Lipopolysaccharide and Peptidoglycan with Mammalian CD14; R. Dziarski, et al. Pathways for the O-Acetylation of Bacterial Cell Wall Polysaccharides; A.J. Clarke, et al. Glycobiology of the Mycobacterial Surface: Structures and Biological Activities of the Cell Envelope Glycoconjugates; M. Daffé, A. Lemassu. Biosynthesis and Regulation of Expression of Group 1 Capsules in Escherichia coli and Related Extracellular Polysaccharides in Other Bacteria; C. Whitfield, et al. Mutans Strepocci Glucosyltransferases; G. Mooser, K.S. Devulapalle. Glycosylhydrolases from Extremophiles; C.E. Vorgias, G. Antanikian. Profiling and Trace Detection of Bacterial Cellular Carbohydrates; A. Fox. Degradation of Cellulose and Starch by Anaerobic Bacteria; K.L. Anderson. The Cellulosome: an Exocellular Organelle for Degrading Plant Cell Wall Oligosaccharides; E.A. Bayer, et al. The Expression of Polysaccharide Capsules in Escherichia coli: A Molecular Genetic Perspective; I.S. Roberts. Bacterial Entry and Subsequent Mast Cell Expulsion of Intracellular Bacteria Mediated by Cellular Cholesterol/glycolipid-Enriched Microdomains; J.-S. Shin, et al. The Fim H Lectin ofEscherichia coli Type 1 Fimbriae: An Adaptive Adhesin; D.L. Hasty, E.V. Sokurenko. Interactions of Microbial Glycoconjugates with Collectins: Implications for Pulmonary Host Defense; I. Ofek, E. Crouch.

Editorial Reviews

‘Overall the book provides an extensive review of our understanding of glycomicrobiology and reveals that the subject is still in the logarithmic phase of growth. The book will therefore be an important source of information and relevant literature references to active researchers in the field.'

The Journal of Medical Microbiology, 50:5 (2001)

‘This book is of greatest use as a reference for researchers interested in the biochemistry of (mainly) surface-expressed glycosylated peptides and lipids. It is extremely comprehensively referenced '

Journal of Antimicrobial Chemotherapy, 49 (2002)

From the Publisher

Reviews major areas of the field of glycomicrobiology, encompassing methods, biochemistry, genetics, molecular biology, cell biology, and enzymology. Provides discussion of carbohydrate-peptide linkages in bacteria, new information on adhesin-receptor complexes involving bacterial pathogens, and a modern outlook on the role of microbial glycoconjugates in the emerging field of biotechnology. The structure and function of glycoconjugates of extremophiles is presented, along with the recognition and metabolism of carbohydrate substrata by microbial enzymes. Other topics are prokaryotic recognition of glycoconjugate eukaryotic receptors, and eukaryotic recognition of prokaryotic receptors. Doyle is affiliated with the University of Louisville. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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