The Golgi Apparatus: State of the art 110 years after Camillo Golgi's discovery / Edition 1

by Alexander A. Mironov, Margit Pavelka

Overview

This book summarizes all new data obtained after development of methods of Golgi complex sub fractionation, molecular biology and microscopy. It collects the full range of expertise, different points of view and different approaches. The book is devoted to molecular modes of the function of the Golgi apparatus as a whole, taking into account all experimental data. The book aims to make the functional organization of the Golgi apparatus more understandable.

Product Details

ISBN-13:	9783211999172
Publisher:	Springer Vienna
Publication date:	12/13/2010
Edition description:	2008
Pages:	716
Product dimensions:	6.10(w) x 9.25(h) x 0.36(d)

Table of Contents

General considerations

The Golgi apparatus and main discoveries in the field of intracellular transport
The Golgi apparatus as a crossroads in intracellular traffic
Main machineries operating at the Golgi apparatus

SNAREs
Rabs
COPII
COPI: mechanisms and transport roles
Arfs and Arls: models for Arf family members in membrane traffic at the Golgi
COG complex
The TRAPP complex
The role of Ca2+ in the regulation of intracellular transport
Golgi glycosylation enzymes
Nucleotide sugar transporters of the Golgi apparatus
Luminal lectins
The Golgi ribbon and the function of the golgins
Functional cross talk between membrane trafficking and cell signalling
The role of the cytoskeleton in the structure and function of the Golgi apparatus
The dynamin–cortactin complex as a mediator of vesicle formation at the trans-Golgi network
The geometry of organelles of the secretory pathway
Main transport steps

ER-to-Golgi transport
Intra-Golgi transport
Structure and domain organization of the trans-Golgi network
Golgi-to-PM transport
Protein transport from the trans-Golgi network to endosomes
The transport of soluble lysosomal hydrolases from the Golgi complex to lysosomes
Transport of lysosomal membrane proteins from the Golgi complex to lysosomes
Retrograde endosome-to-TGN transport
Retrograde plasma membrane-to-Golgi apparatus transport
Interactions between endocytosis and secretory transport
Origins of the regulated secretory pathway
Secretion and endocytosis in endothelial cells
Formation of mucin granules
Golgi apparatus and epithelial cell polarity
Golgi apparatus inheritance
Peculiarities of intracellular transport in different organisms

Features of the plant Golgi apparatus
Yeast Golgi apparatus
Morphodynamics of the yeast Golgi apparatus
Structure and function of the Golgi organelle in parasitic protists
Evolution of the Golgi complex
General conclusions