Guidelines for the Treatment of Malaria

by World Health Organization

Overview

This third edition of the WHO Guidelines for the Treatment of Malaria contains updated recommendations based on a firmer evidence base for most antimalarial drugs and in addition includes recommendations on the use of drugs to prevent malaria in groups at high risk.

The Guidelines provide a framework for designing specific, detailed national treatment protocols, taking into account local patterns of resistance to antimalarial drugs and health service capacity. It provides recommendations on treatment of uncomplicated and severe malaria in all age groups, all endemic areas, in special populations and several complex situations. In addition on the use of antimalarial drugs as preventive therapy in healthy people living in malaria endemic areas who are high risk, in order to reduce morbidity and mortality from malaria.

Product Details

ISBN-13:	9789241549127
Publisher:	World Health Organization
Publication date:	12/16/2015
Edition description:	3rd ed.
Pages:	319
Product dimensions:	6.30(w) x 9.40(h) x 0.70(d)

About the Author

World Health Organization is a Specialized Agency of the United Nations, charged to act as the world's directing and coordinating authority on questions of human health. It is responsible for providing leadership on global health matters, shaping the health research agenda, setting norms and standards, articulating evidence-based policy options, providing technical support to countries, and monitoring and assessing health trends.

Table of Contents

1 Introduction 15

2 Clinical malaria and epidemiology 23

3 Diagnosis of malaria 27

4 Treatment of uncomplicated Plasmodium falciparum malaria 31

5 Treatment of uncomplicated P. falciparum malaria in special Risk Groups 47

6 Treatment of uncomplicated malaria caused P. Vivax P. Ovale P. Malariae P. Knowlesi 59

7 Treatment of severe malaria 71

8 Management of malaria cases in special, situations 89

9 Artemisinin-based combination therapies not currently recommended for general use 93

10 Mass drug administration 95

11 Chemoprevention in special risk groups 99

12 Quality of antimalarial medicines 107

13 Monitoring the efficacy and safety of antimalarial drugs and resistance 111

14 National adaptation of the generic framework for malaria diagnosis and treatment, and implementation 115

Annex 1 Preparation of the guidelines 125

Annex 2 Malaria transmission and antimalarial medicines 129

Annex 3 Malaria diagnose IV

Annex 4 Grading of Recommendations Assessment, Development and Evaluation (GRADE) for assessing the quality of evidence 145

Annex 5 Pharmacology of antimalarial, drugs 205

Annex 6 Treatment of Plasmodium vivax, P. ovale, P. malariae and P. knowlesi infections 285

Annex 7 Resistance to antimalarial medicines 299