Handbook Of Photodynamic Therapy: Updates On Recent Applications Of Porphyrin-based Compounds

by Ravindra K Pandey (Editor), Thomas J Dougherty (Editor), David Kessel (Editor)

Overview

The main objective of this book is to present the recent applications of photodynamic therapy (PDT) in treating cancer and other diseases. The limitations associated with current PDT agents, and the synthetic designs that have been used in various laboratories are also discussed. The utility of certain tumor-avid agent for cancer imaging (fluorescence, PET, MRI) is also summarized. The book also includes the use of delivery vehicles, including nanoparticles in improving the tumor-specificity of the desired agents. The book is basically focused on the translational approach of drug development. By providing certain specific examples, a clear concept of moving a 'product' from the bench to bed-side is also discussed.To have a clear concept of drug development the book is divided in three parts — Medicinal Chemistry, Mechanistic and Clinical studies. Each part includes the contributions from the leading scientists with extensive experience in the respective field. The handbook is assembled by renowned scientists Dr Dougherty, known as the father of PDT, Dr Kessel, well known for his contributions on mechanism of PDT and Dr Pandey for his inventions in developing improved agents for PDT and cancer-imaging.

Product Details

ISBN-13:	9789814719643
Publisher:	World Scientific Publishing Company, Incorporated
Publication date:	06/02/2016
Pages:	564
Product dimensions:	7.00(w) x 9.60(h) x 1.10(d)

Table of Contents

Preface ix

Part 1 1

1 Multifunctional Agents for Cancer-Imaging and Photodynamic Therapy: Impact of Polyacrylamide-Based Nanoplatforms Aimee Marko Nayan J. Patel Penny Joshi Joseph R. Missert Ravindra K. Pandey 3

2 Design and Synthesis of Photosensitizer-Peptide Conjugates for PDT Tyrslai M. Williams Martha Sibrian-Vazquez M. Graça H. Vicente 45

3 Current Developments in Using MESO-(TETRA) Substituted Porphyrins for PDT Yasser M. Shaker Ayman M. K. Sweed Claire Moylan Luke Rogers Aoife A. Ryan Rosine Petitdemange Mathias O. Senge 95

4 Core-Modified Porphyrins as Photosensitizers in Photodynamic Therapy Michael R. Detty 151

5 Phthalocyanines in Cancer-Imaging and Therapy Hasrat Ali Johan E. van Lier 173

6 Molecular Phthalocyanine-Based Photosensitizes for Photodynamic Therapy Pui-Chi Lo Sun Y. S. Chow Dennis K. P. Ng 237

7 Porphyrin Nanoparticles for Cancer Imaging and Phototherapy Liyang Cui Juan Chen Gang Zheng 273

8 Photodynamic Therapy Dosimetry: A TO Z Michael S. Patterson 295

Part 2 317

9 PDT: Death and Survival Pathways David Kessel 319

10 Vascular Effects of Photodynamic Therapy for Tumors Keith A. Cengel Charles B. Simone Theresa M. Busch 335

11 EtNBS in Photodynamic Therapy Nicholas H. Nowell Hsin-I Hung Lauren A. Austin Conor L. Evans 365

12 Negative Impact of Tumor-Generated Nitric Oxide on Photodynamic Therapy Albert W. Girotti 401

13 On the Use of Photodynamic Therapy, as Monotherapy or in Combination, in the Treatment of Polypoidal Choroidal Vasculopathy: An Update Hubert van den Bergh Patrycja Nowak-Sliwinska 421

Part 3 437

14 Photodynamic Therapy of Head and Neck Cancer - What's Old and What's New Merrill A. Biel 439

15 Endoscopic Photodynamic Therapy for Advanced Inoperable Esophageal Cancer Joerg Lindenmann 459

16 PDT for Lung Cancer Keishi Ohtani Norihiko Ikeda 485

17 New Developments in Antimicrobial PDT Wolfgang Bäumler 501

18 Antimicrobial Effects of Photosensitized Silicon Phthalocyanine (Pc) 4 Mink Lam Matthew L. Dimaano Pranab K. Mukherjee Mahmoud A. Ghannoum Nancy L. Oleinick Elma D. Baron 521

19 Photofrin-PDT from Bench to Bedside: Some Lessons Learned Julia Levy Ed Levy 531

Index 549