Heart Failure in the Child and Young Adult: From Bench to Bedside

by Joseph Rossano M.D., M.S. (Editor), John Lynn Jefferies (Editor), Anthony C. Chang MD, MBA, MPH (Editor), Jeffrey A. Towbin MD (Editor), Robert E Shaddy MD (Editor)

Overview

Heart Failure in the Child and Young Adult: From Bench to Bedside, Second Edition highlights unique aspects of heart failure in the young. This comprehensive resource combines research from multiple contributors with current guidelines to bridge the knowledge gap for the recognition and management of heart failure in children. Coverage begins with the basic science of heart failure and then progresses through diagnosis, management, treatment, and surgery, finally concluding with advanced special topics, including genetics, self-management, and nanomedicine.

This new edition covers advancements in the field, including additional chapters and discussion on biomarkers, neuromuscular disease, quality of life, palliative care, and the impact of COVID-19 in myocarditis and multisystem inflammatory syndrome in children. It will serve as an indispensable reference to basic science researchers in cardiology, pediatrics, cardiologists, and pediatric cardiologists.

Product Details

ISBN-13:	9780443132797
Publisher:	Elsevier Science
Publication date:	10/30/2025
Edition description:	2nd ed.
Pages:	1000
Product dimensions:	8.50(w) x 10.88(h) x (d)

About the Author

Dr. Rossano is the medical director of Pediatric Heart Transplant and Heart Failure. He is also an attending physician in the Cardiac Center and the Cardiac Intensive Care Unit (CICU) and an assistant professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. Dr. Rossano is principal investigator or co-investigator on several ongoing research studies of the use of ventricular assist devices and artificial hearts in children, studying the effectiveness of post-transplant treatments for children who have received heart transplants, an observational study of children with heart failure, and building a registry of pediatric heart transplant patients that aims to further the knowledge of pediatric heart disease and transplantation.

Dr. Jefferies is a recognized international expert in the field of heart muscle disease contributing much of the current literature regarding related genetic mechanisms, clinical investigation, and guideline development.

Dr. Chang is the founder and medical director of the Medical Intelligence, Information, Investigation, and Innovation Institute (Mi4) that is supported by the Sharon Disney Lund Foundation. The institute is dedicated to the introduction and implementation of artificial intelligence in medicine and was the first institute of its kind in a hospital. Dr. Chang intends to build a clinician-computer scientist interface with a nascent society (the Medical Intelligence Society) and is the editor-in-chief of Intelligence-based Medicine, the accompanying journal for his book, Intelligence-Based Medicine: Artificial Intelligence and Human Cognition in Clinical Medicine and Healthcare. He is the organizing chair for Artificial Intelligence in Medicine (AIMed) meetings around the world, the largest and most comprehensive clinician-led meetings that focus on applications of artificial intelligence in medicine and the dean of the nascent American Board of Artificial Intelligence in Medicine (ABAIM). He is also the founding president of the Medical Intelligence Society (MIS).

Dr. Towbin is a recognized international expert in the field of heart muscle disease contributing much of the current literature regarding related genetic mechanisms, clinical investigation, and guideline development.

Dr. Shaddy is Chief of the Division of Cardiology at The Children’s Hospital of Philadelphia and holds the Jennifer Terker Endowed Chair in Pediatric Cardiology. He is Professor of Pediatrics and Vice Chair of the Department of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. Dr. Shaddy brings more than 25 years of experience as a cardiologist caring for children with heart failure to his role as one of the leaders of the transplant program.

Dr. Miyamoto is the Director of the Cardiomyopathy Program and Professor of Pediatrics at Children’s Hospital Colorado and the University of Colorado. She is a nationally and internationally recognized authority on pediatric cardiac transplantation and cardiomyopathy, much of her groundbreaking work focuses on the failing heart of children with cardiomyopathies and congenital heart disease.

Table of Contents

Section I: Basic Science of Heart Failure
1. Molecular and Cellular Mechanisms in Heart Failure including Models of Heart Failure
2. Cardiovascular Receptors and Signaling in Heart Failure
3. Inflammatory Mediators in Heart Failure
4. Epigenetics and Transcriptomics
5. Mechanisms of Hypertrophy in Heart Failure
6. Hemodynamic Adaptive Mechanisms in Heart Failure
7. Neurohormonal Axis and Natriuretic Peptides in Heart Failure
8. Biomarkers in Heart Failure
9. Mechanisms of systolic and diastolic dysfunction
10. Echocardiographic Quantitation of Ventricular Function
11. Magnetic Resonance Imaging Assessment of Heart Failure
12. Assessment of Heart Failure by Invasive Methods
13. Lymphatic System in Heart Failure
14. Endothelial Dysfunction

Section II: Clinical Diagnosis and Management of Pediatric Heart Failure
15. Epidemiology and Economic Aspects of Pediatric Heart Failure
16. Clinical Recognition of Heart Failure in Children
17. Classification of Heart Failure
18. Right Ventricular Dysfunction
19. Pediatric Myocarditis
20. Dilated Cardiomyopathy
21. Clinical Features of Restrictive Cardiomyopathy and Constrictive Pericarditis
22. Hypertrophic Cardiomyopathy
23. Left Ventricular Noncompaction
24. Arrhythmogenic Cardiomyopathies
25. Valvular Insufficiency and Heart Failure
26. Valvular Stenosis and Heart Failure
27. Coronary Artery Disease in Children and Young Adults
28. Heart Failure in Congenital Heart Disease Including Single Ventricle Circulation
29. Heart Failure in Adults with Congenital Heart Disease
30. Dysrhythmias and Ventricular Dysfunction and Heart Failure
31. Heart Failure in the Fetus
32. Heart Failure in the Neonate
33. Heart Failure in Pediatric Pulmonary Diseases
34. Cardiorenal Syndrome
35. Heart Failure in Pediatric Oncologic Disease
36. Neuromuscular Diseases
37. Sickle Cell Disease
38. The Cardiovascular System in Systemic Inflammatory Syndromes
39. Outpatient Management
40. Cardiac Intensive Care and Inpatient Management
41. Quality of Life and Psychosocial Care
42. Palliative Care
43. Quality Improvement and Learning Collaboratives
44. Nursing Aspects of Heart Failure

Section III: Medical Treatment for Pediatric Heart Failure
45. Diuretics and Invasive Fluid Management Strategies
46. Inotropic Agents in Heart Failure
47. Phosphodiesterase Inhibitors
48. Inhibition of the Renin-Angiotensin-Aldosterone System and Other Vasodilators
49. Beta-adrenergic Receptor Blockade
50. Low Cardiac Output Syndrome in the Intensive Care Setting
51. New Therapeutic Strategies in Heart Failure
52. Electrophysiologic Devices in Heart Failure
53. Catheter Device Therapy for Heart Failure

Section IV: Cardiac Surgery and Pediatric Heart Failure
54. Post-Transplant Heart Failure
55. Surgical Strategies for the Failing Systemic Ventricle
56. Valve Intervention for Valve Failure
57. General Principles of Mechanical Cardiopulmonary Support
58. Short-Term Mechanical Cardiopulmonary Support Devices
59. Decision Making in Ventricular Assist Device Support in Pediatric Patients
60. Long-Term Ventricular Assist Devices and Destination Therapy
61. Future of Mechanical Support Devices in Children and Young Adults

Section V: Special Topics
62. Genetics and Genomics
63. Genetic Testing
64. Data Management and Analytics
65. Self-Management and Outpatient Monitoring
66. Regenerative Medicine
67. Nanomedicine
68. Digital Twin and Innovation in Research Design
69. Nutritional Assessment and Management in Pediatric Heart Failure

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From the Publisher

A comprehensive reference on pediatric heart failure covering everything from basic science, to the most up-to-date therapies