Immunotherapy of Cancer / Edition 1

by Mary L. Disis

Overview

Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunologic monitoring-and the new advances and directions in cancer immunotherapy are also fully examined.

Product Details

ISBN-13:	9781617376450
Publisher:	Springer-Verlag New York, LLC
Publication date:	12/09/2010
Series:	Cancer Drug Discovery and Development
Edition description:	Softcover reprint of hardcover 1st ed. 2006
Pages:	516
Product dimensions:	7.01(w) x 10.00(h) x 0.04(d)

Table of Contents

Discovery of Target Molecules for Cancer Immunotherapy by Genetic and Bioinformatic Approaches.- Current Strategies for the Identification of Immunogenic Epitopes of Tumor Antigens.- Current and Future Role of Natural-Killer Cells in Cancer Immunotherapy.- The Role of Immune Monitoring in Evaluating Cancer Immunotherapy.- Statistical Analysis of Immune Response Assays in Cancer Immunotherapy Trials.- DNA Vaccines for Cancer Immunotherapy.- Dendritic Cells.- Different Approaches to Dendritic Cell-Based Cancer Immunotherapy.- Anti-Idiotype Antibody Vaccines for the Immunotherapy of Cancer.- Autologous Tumor-Derived Heat Shock Protein Vaccine as a New Paradigm for Individualized Cancer Therapeutics.- Tumor-Reactive T-Cells for Adoptive Immunotherapy.- T-Cell Adoptive Immunotherapy of Cancer.- Retroviral-Mediated Gene Transfer for Engineering Tumor-Reactive T-Cells.- Harnessing the Potential of Graft-vs-Tumor.- Tumor-Induced Immune Suppression and Immune Escape.- The Tumor Microenvironment.- Manipulation of Lymphocyte Homeostasis for Enhancing Antitumor Immunity.- Fast-Lane Evolution in the Tumor Microenvironment.- Manipulating Immunological Checkpoints to Maximize Antitumor Immunity.- Interleukin-2 as Cancer Therapy.- Biological and Clinical Properties of the Type 1 Interferons.- Promising—-Chain Cytokines for Cancer Immunotherapy.- The Therapeutic Use of Natural-Killer Cells in Hematological Malignancies.- Antibody Therapy for Solid Tumors.- Antibody Therapy for Non-Hodgkin’s Lymphoma.- Approaches to In Vivo Imaging of Cancer Immunotherapy.- Design Issues for Early-Stage Clinical Trials for Cancer Vaccines.- Monoclonal Antibody Therapy of Cancer.

Editorial Reviews

From the reviews:

"Immunotherapy of Cancer provides in 28 chapters a comprehensive overview of experimental and clinical achievements in tumor immunology. Each chapter is designed to give the reader the scientific basis behind the discussed therapy and outline basic theory, as well as practical treatment applications. … The book belongs to the successful series of publications Cancer Drug Discovery and Development from Humana Press. It will be of interest to clinicians and to laboratory cancer researchers … ." (Cestmir Altaner, Neoplasma, Vol. 54 (2), March, 2007)

From the Publisher

Reviewer: Timothy M Kuzel, MD (Northwestern University Feinberg School of Medicine)
Description: This book provides a comprehensive overview of the field of tumor immunology, including both scientific rationale and clinical application for oncologic therapy. It provides important background for practitioners to help optimize future diverse research projects.
Purpose: The authors' purpose in writing this book is to provide a springboard for applying the most important findings in tumor immunology to any future basic laboratory or clinical research program. This much needed book summarizes the work previously done in the field to avoid duplication in the future, and provides basic concepts to improve the rigor of both laboratory and clinical interventions. The individual chapters appropriately follow these goals.
Audience: The book is written at the level of researchers in the field of tumor immunology, although the chapters approach each topic from basic background to cutting-edge new developments. This allows newcomers to the field to appreciate the breadth and depth of the field. The authors of each chapter are sufficiently credible to make each chapter relevant.
Features: In general terms, the content reflects the current status of tumor immunology. The book addresses multiple effectors of the immune system including vaccines, dendritic cells, natural killer cells, T-cells and monoclonal antibodies. In addition, the book addresses basic research concepts that relate to the field in general, including strategies for identifying new tumor targets and immune monitoring with statistical concepts. These latter sections provide a truly helpful description to help practitioners design effective trials of immunotherapy approaches. The only shortcomings reflect the need to limit each topic to several chapters, so that each topic can only be covered broadly. Researchers interested in an in-depth review of a specific field will need to use the references to identify additional material for review.
Assessment: This book represents a truly novel approach to the field. The inclusion of statistical methods and experimental designs is the most unique and helpful aspect of the book, an area not well covered previously.

Doody's Review Service