Pub. Date:
Springer Berlin Heidelberg
Insights into Receptor Function and New Drug Development Targets / Edition 1

Insights into Receptor Function and New Drug Development Targets / Edition 1

by P. Michael Conn, Claude Kordon


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Product Details

ISBN-13: 9783540344469
Publisher: Springer Berlin Heidelberg
Publication date: 09/14/2006
Series: Research and Perspectives in Endocrine Interactions
Edition description: 2006
Pages: 202
Product dimensions: 6.10(w) x 9.25(h) x 0.02(d)

Table of Contents

Molecular and Functional Diversity of the TRP Family of Ion Channels. TRPC Channels and the ROCE/SOCE Conundrum.- Functional rescue of misfolded receptor mutants.- Obesity-related mutations of leptin and melanocortin receptors.- cAMP and cGMP-dependent control of lipolysis and lipid mobilization in humans: putative targets for fat cell management.- Central neuropeptide receptors involved in water balance : application to apelin.- Targeting regulators of G protein signalling (RGS proteins) to enhance agonist selectivity.- Dimeric GPCRs: what did we learn from the metabotropic glutamate receptors.- Guiding principles applied in the design of GPCR-selective hypothalamic hormone agonists and antagonists.- Mutations in G proteins and G protein-coupled receptors in human disease.- A molecular dissection of glycoprotein hormone receptors.- Receptor Tyrosine Kinases as Target for Cancer Therapy Development.- Targets for pituitary tumor therapy.- The endogenous cannabinoid system in the control of food intake and energy balance.- Subject Index

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