Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development

by A. Yacobi, J.P. Skelly, Vinod P. Shah, L.Z. Benet

Overview

Proceedings of a conference sponsored by the American Association of Pharmaceutical Scientists, the U.S. Food and Drug Administration, and the American Society for Clinical Pharmacology and Therapeutics, held in Arlington, Virginia, April 24-26, 1991

Product Details

ISBN-13:	9781475715224
Publisher:	Springer US
Publication date:	05/30/2013
Edition description:	Softcover reprint of the original 1st ed. 1993
Pages:	270
Product dimensions:	6.69(w) x 9.61(h) x 0.02(d)

Table of Contents

Introduction: The Case for Preclinical Pharmacodynamics (G. Levy). Preclinical Pharmacokinetic and Pharmacodynamic Studies: Pharmacokinetics and Drug Metabolism in Animal Studies (G.G. Fitzgerald). Methodology for Preclinical Pharmacodynamic Studies: Preclinical Pharmacodynamics of Central Nervous System Active Agents (M. Danhof et al.). Preclinical and Clinical Pharmacokinetics: The Role of Pharmacokinetics in the Drug Development Process (L.Z. Benet). Clinical Pharmacodynamics: The Value of PlasmaWayfarin Measurement (R.A. O'Reilly). Application of Pharmacodynamics and Pharmacokinetics in the Drug Development Process: ConcentrationControlled Trials (L. Sanathanan, C.C. Peck). Summary Report: Opportunities for Integration of Pharmacokinetics, Pharmcodynamics, and Toxicokinetics in Rational Drug Development. 19 additional articles. Index.