Interferon Therapy of Multiple Sclerosis

by Anthony Reder (Editor)

Overview

This reference presents cutting-edge basic and clinical research on all forms of interferon (IFN) involvement in the management of multiple sclerosis (MS)-detailing topics from IFN-receptor molecular interactions to synergy and interference with other agents such as cytotoxic drugs and chemotherapy. Features detailed research findings on IFN ß -1a (Avonex) and IFN -1b (Betaseron).

Product Details

ISBN-13:	9780824797645
Publisher:	Taylor & Francis
Publication date:	01/28/1997
Edition description:	New Edition
Pages:	570
Product dimensions:	6.00(w) x 9.00(h) x (d)

Table of Contents

The Molecular Biology of Interferon-ß from Receptor Binding to Transmembrane Signaling, Lawrence M. Pfeffer and Stefan N. Constantinescu
The Molecular Biology of Type I Interferons (Interferon- /ß) (Gene Activation, Promoters, Proteins Induced), Thomas Decker
Pharmacokinetics of Interferon-ß and the Biological Markers It Induces, Patricia L. Witt
Interferons and the Central Nervous System Glia, Timothy Vartanian
Effects of Interferon on the Central Nervous System, Nachum Dafny, Bertha Prieto-Gomez, and Cruz Reyes-Vazquez
Neuropsychological Effects of Interferon Therapy, Neil H. Pliskin, Anthony T. Reder, and Diane S. Goldstein
The Effects of Interferon-ß on Cytokines and Immune Responses, Peter Rieckmann
The Pathogenetic Role of Interferon- in Multiple Sclerosis, Gianvito Martino and Luigi M. E. Grimaldi
The Effects of Interferons and Other Cytokines on Experimental Autoimmune Encephalomyelitis, Hubertine Heremans and Alfons Billiau
Effects of Oral Administration of Type I Interferons on Experimental Autoimmune Encephalomyelitis, Staley A. Brod
Interferon- in the Treatment of Multiple Sclerosis, Lorne F. Kastrukoff and Joel J.-F. Oger
Recombinant Interferon- in the Treatment of Multiple Sclerosis: Effects on Exacerbation Rate, Magnetic Resonance Imaging of Lesion Activity, and Cytokines, Luca Durelli
Inteferon ß-1a Treatment of Multiple Sclerosis, Robert M. Herndon
Inteferon ß-1b (Betaseron) Treatment of Multiple Sclerosis, Robert L. Knobler
Effects of Inteferon ß-1b on Multiple Sclerosis Lesions Evaluated by Magnetic Resonance Imaging and Other Magnetic Resonance Techniques, Robert A. Koopmans, David K. B. Li, Guo Jun Zhao, Elana Brief, Alex MacKay, Irene Vavasour, Ken Whittall, and Donald W. Paty
Adverse Effects of Interferons, Richard Cirelli, Kathleen B. Herne, Monica L. McCrary, and Stephen K. Tyring
Interferon-t: A Potential Treatment for Inflammatory Central Nervous System Disease, Jeanne M. Soos, Joel Schiffenbauer, Howard M. Johnson, and Carol H. Pontzer
Clinical Trials of Multiple Sclerosis, Jeremy C. Hobart and Alan J. Thompson
The Incidence and Clinical Significance of Antibodies to Interferon-a, Kjell Öberg and Rachel M. McKenna
Quantitation and Characterization of Multiple Sclerosis Patient Antibodies to Interferon-ß, Eirik Nestaas, James G. Files, Jeffrey W. Nelson, and Erno Pungor, Jr.

Editorial Reviews

"
…an excellent reference for anyone interested in the basic mechanisms of action of the interferons and the clinical chapters provide a clear account of their role in the current management of patients with multiple sclerosis."-The Canadian Journal of Neurological Sciences, 1998

From the Publisher

Twenty essays investigating the role of interferons (IFN) in the treatment of multiple sclerosis (MS) expand published and unpublished work that compares all forms of IFN, treatment implications, synergy or interference with other agents, and hypotheses on how IFNs prevent disease activity in MS. The contributors report on an array of clinical experience, highlighting the molecular biology of IFN binding to its receptors, and descriptions of IFN pharmacokinetics, clinically oriented benefits and side effects of IFN in MS, the role of current and future magnetic resonance techniques for imaging MS lesions, and a review of therapy with oral and systemic IFN based on the experimental allergic encephalomyelitis (EAE) model. Includes illustrations and photographs. Annotation c. by Book News, Inc., Portland, Or.

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