Introduction to Toxicology

by John Timbrell, Frank A. Barile

Overview

As with the previous editions, Introduction to Toxicology, Fourth Edition, continues to chart the evolution of the field of toxicology, from the use of natural toxins by ancient tribes through the developments established by Paracelsus, and progresses through to the current topics in the public interest. For centuries, the study of toxicology has fascinated students. The book begins with basic toxicological principles, including an historical summary, dose-response relationships (NEW chapter), exposure-response relationships (NEW chapter), disposition, and metabolism of xenobiotic toxic substances. Other important new chapters include target organ toxicity, toxicity of carcinogenic agents and new and updated concepts in toxicity testing, and antidotes and treatment of poisonings. In all, nine new or expanded chapters from the third edition are advanced.

Current concerns about the effects of therapeutic drugs, carcinogens, industrial toxins, pesticides, and herbicides on human health, animal welfare, and the stability and maintenance of the ecosystem continue to highlight toxicology as an important and growing scientific discipline.

Key features:

• Comprehensive coverage of the field of toxicology which illustrates its importance to and impact on society
• Uses pertinent examples, tables, and diagrams to aid understanding with learning objectives, summaries, questions, and answers for each chapter
• Clearly and concisely written and presented concepts for easy comprehension by toxicology, biomedical, and health science students
• Examines the complex interactions associated with toxicological events
• Covers the effect of toxins on biological and physiological systems

This book successfully condenses the diffuse literature in the field into an accessible and readable text, made easier with the insertion of many tables and figures. It introduces fundamental concepts and builds upon these using topical and relevant historical examples. Its improved format includes learning objectives and summaries of each chapter, as well as questions and answers suitable for self-assessment.

This latest edition is an invaluable resource for undergraduate and graduate toxicology students, as well as an introductory text for other health care students and professionals. The book also functions as a comprehensive introductory reference text for environmental scientists, medical biologists and chemists, chemical engineers, and regulatory agencies, with interests in toxicologically related areas.

Product Details

ISBN-13:	9781032036922
Publisher:	CRC Press
Publication date:	02/27/2023
Edition description:	4th ed.
Pages:	316
Product dimensions:	6.70(w) x 9.30(h) x 0.60(d)

About the Author

John Timbrell is Emeritus Professor of Biochemical Toxicology in the Pharmacy Department at King's College London and was a member of the Commitee on Toxicigy, U.K.Govenment. He was the founding Editor of the journal Biomarkers (Taylor and Francis Ltd). Publishers. He has been involved with the teaching and development of toxicology courses at both undergraduate and postgraduate level for 30 years.

Frank A. Barile is retired Professor of Toxicology in the Pharmaceutical sciences Department, St. John’s University College of Pharmacy and Health Sciences, New York. He is past President of the In Vitro and Alternative Methods (IVAM) Specialty Section of the U.S. Society of Toxicology and a former member of the Scientific Advisory Committee for Alternative Toxicological Methods (SACATM), NIEHS, U.S. National Institutes of Health. He is former Chief Editor of Toxicology in Vitro.

Table of Contents

1. Introduction. 2. Dose-Response Relationship. 3. Exposure-Response Relationship. 4. Disposition of Toxic Compounds. 5. Metabolism of Xenobiotic Compounds. 6. Target Organ Toxicity. 7. Carcinogenic and Mutagenic Compounds. 8. Drugs as Toxic Substances. 9. Industry Toxicology. 10. Food Additives and Contaminants. 11. Pesticides and Herbicides. 12. Environmental Pollutants. 13. Natural Products. 14. Commercial and Domestic Products. 15. Fundamentals of Toxicity Testing. 16. Risk Assessment. 17. Antidotes and Treatment of Poisoning. Answers to Chapter Questions. Glossary.

Editorial Reviews

3 Stars from Doody

An introductory textbook on toxicology for undergraduate and graduate students and for novice toxicologists and scientists who want an overview of the field without having to pay for and wade through a specialized tome. Intended for readers with a wide variety of backgrounds, and so assumes no more than knowledge of basic scientific principles and terms. Some details have been changed, and the references updated since the 1988 edition. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews

Reviewer: Tracie Marie Caslin, BS, MS (Oregon State University)
Description: This is an introduction to the broad field of toxicology. The previous edition was published in 1995.
Purpose: The purpose, according to the author, is to provide an introductory toxicology book that is reasonably inexpensive and serves as an introduction to the subject for students with backgrounds in various disciplines. A book with this objective is noteworthy and necessary with the growing awareness of, and concern about, chemicals within multiple disciplines.
Audience: This book is written to introduce the student to the basic concepts and issues in toxicology. It does not address many of the biochemical pathways usually provided in upper division toxicology courses for the toxicology major or professional. The book provides a good foundation in toxicology for students from multiple disciplines and describes well the applications this field has in other fields and interests.
Features: The author provides a thorough introduction to basic toxicological concepts, current regulations, chemical testing, and risk assessment. Due to the growing concern about chemical toxicities in wildlife, domestic animals, and public health, an entire chapter devoted to toxicity testing and risk assessment is applaudable. The author, a credible authority, does not always remain unbiased and objective.
Assessment: This is a high-quality, useful book for students looking for an introduction to the field of toxicology and issues and regulations overlapping with multiple disciplines. I am not aware of any other book that has done this in such an inexpensive and condensed manner. Due to the inevitable advances in technology and the many discussions on current issues and regulations in this book, this new edition, as well as future changes, are necessary.

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