Ionotropic Glutamate Receptors in the CNS / Edition 1 available in Hardcover
- Pub. Date:
- Springer Berlin Heidelberg
This volume provides an overview of glutamate receptors and their role in excitatory neurotransmission. It focusses on three aspects. First, it describes the functional, molecular, and pharmacological propertie s of glutamate receptors (AMPA, NMDA, and kainate receptors). Second, it gives a survey how these receptors are involved in synaptic transmi ssion at different glutamatergic synapses in the mammalian CNS. Finall y, it adresses how overactivation of glutamate receptors can lead to e xcitotoxic cell death, and emphasizes the importance of glutamate rece ptors as potential therapeutical targets. The chapters, written by lea ding scientists, give accurate summaries of facets that have emerged r ecently in this field. The book demonstrates the strength of a multidi sciplinary approach involving physiology, pharmacology, and molecular biology. It will be useful for other scientists in and outside the fie ld, lecturers and students at different educational levels.
Table of ContentsSection I: Molecula r Structure of Glutamate Receptors.- 1 Structure of Ionotropic Glutamate Receptors.- 2 Phosphorylation of Glutamate Receptors.- 3 The Synaptic Protein Network Associated with Ionotropic Glutamate Receptors.- 4 Cellular and Subcellular Distribution of Glutamate Receptors.- Section II: Functional Properties of Glutamate Receptors.- 5 Activation of Single AMPA- and NMDA-Type Glutamate-Receptor Channels.- 6 The Ion-Conducting Pore of Glutamate Receptor Channels.- 7 Block of AMPA and Kainate Receptors by Polyamines and Arthropod Toxins.- 8 Kainate Receptors.- 9 Molecular Determinants Controlling Functional Properties of AMPARs and NMDARs in the Mammalian CNS.- Section III: Glutamatergic Synaptic Transmission.- 10 Morphological Characteristics of Glutamatergic Synapses in the Hippocampus.- 11 Glutamate-Mediated Synaptic Excitation of Cortical Interneurons.- 12 Physiology of Glutamatergic Transmission at Calyceal and Endbulb Synapses of the Central Auditory Pathway.- 13 Glutamate Transporters and Their Contributions to Excitatory Synaptic Transmission.- Section IV: Involvement of Glutamate Receptors and Transporters in Neurological Diseases.- 14 Glutamate-Mediated Excitotoxicity.- 15 Glutamate Transporter Dysfunction and Neuronal Death.- 16 NMDA Recepor Antagonists and Their Potential as Neuroprotective Agents.