Liposomes: Methods and Protocols, Volume 1: Pharmaceutical Nanocarriers / Edition 1

by Volkmar Weissig

Overview

Efforts to describe and model the molecular structure of biological membranes go back to the beginning of the last century. In 1917, Langmuir described membranes as a layer of lipids one molecule thick [1]. Eight years later, Gorter and Grendel concluded from their studies that “the phospholipid molecules that formed the cell membrane were arranged in two layers to form a lipid bilayer” [2]. Danielli and Robertson proposed, in 1935, a model in which the bilayer of lipids is sequestered between two monolayers of unfolded proteins [3], and the currently still accepted fuid mosaic model was proposed by Singer and Nicolson in 1972 [4]. Among those landmarks of biomembrane history, a serendipitous observation made by Alex Bangham during the early 1960s deserves undoubtedly a special place. His fnding that exposure of dry phospholipids to an excess of water gives rise to lamellar structures [5] has opened versatile experimental access to studying the biophysics and biochemistry of biological phospholipid membranes. Although during the following 4 decades biological membrane models have grown in complexity and functionality [6], liposomes are, besides supported bilayers, membrane nanodiscs, and hybrid membranes, still an indisputably important tool for membrane b- physicists and biochemists. In vol. II of this book, the reader will fnd detailed methods for the use of liposomes in studying a variety of biochemical and biophysical membrane phenomena concomitant with chapters describing a great palette of state-of-the-art analytical technologies.

Product Details

ISBN-13:	9781603273596
Publisher:	Springer-Verlag New York, LLC
Publication date:	12/18/2009
Series:	Methods in Molecular Biology , #605
Edition description:	2010
Pages:	564
Product dimensions:	7.00(w) x 10.10(h) x 1.50(d)

Table of Contents

Preface v

Contributors xi

1 Current Trends in Liposome Research Tamer A. ElBayoumi Vladimir P. Torchilin 1

2 Nanoliposomes: Preparation and Analysis M.R.Mozafari 29

3 Preparation of DRV Liposomes Sophia G. Antimisiaris 51

4 Elastic Liposomes for Topical and Transdermal Drug Delivery Heather A.E. Benson 77

5 Archaebacterial Tetraetherlipid Liposomes Aybike Ozcetin Samet Mutlu Udo Bakowsky 87

6 Cationic Magnetoliposomes Marcel De Cuyper Stefaan J.H. Soenen 97

7 Ultrasound-Responsive Liposomes Shao-Ling Huang 113

8 Liposome Formulations of Hydrophobic Drugs Reto A. Schwendener Herbert Schott 129

9 Remote Loading of Antbracyclines into Liposomes Felicitas Lewrick Regine Peschka Süss 139

10 Arsonoliposomes: Preparation and Physicochemical Characterization Sophia G. Antimisiaris Panayiotis V. Ioannou 147

11 Liposome-Based Vaccines Reto A. Schwendener Burkhard Ludewig Andreas Cerny Olivier Engler 163

12 Mannosylated Liposomes for Targeted Vaccines Delivery Suresh Prasad Vyas Amit K. Goyal Kapil Khatri 177

13 Liposomes for Specific Depletion of Macrophages from Organs and Tissues Nico van Rooijen Esther Hendrikx 189

14 Vesicular Phospholipid Gels Martin Brandl 205

15 Environment-Responsive Multifunctional Liposomes Amit A. Kale Vladimir P. Torchilin 213

16 Functional Liposomal Membranes for Triggered Release Armağan Koçer 243

17 A "Dock and Lock" Approach to Preparation of Targeted Liposomes Marina V. Backer Joseph M. Backer 257

18 Conjugation of Ligands to the Surface of Preformed Liposomes by Click Chemistry Benoît Frisch Fatouma Saïd Hassane Francis Schuber 267

19 Targeted Magnetic Liposomes Loaded with Doxorubicin Pallab Pradhan Rinti Banerjee Dhirendra Bahadur Christina Koch Olga Mykbaylyk Christian Plank 279

20 Liposomes for Drug Delivery to Mitochondria Sarathi V. Boddapati Gerard G.M. D'Souza Volkmar Weissig 295

21 Cytoskeletal-Antigen Specific Immunoliposomes: Preservation of Myocardial Viability Vishwesh Patil Tala Khudairi Ban-An Khaw 305

22 Gadolinium-Loaded Polychelating Polymer-Containing Tumor-Targeted Liposomes Suna Erdogan Vladimir P. Torchilin 321

23 Angiogenic Vessel-Targeting DDS by Liposomalized Oligopeptides Tomohiro Asai Naoto Oku 335

24 TAT-Peptide Modified Liposomes: Preparation, Characterization, and Cellular Interaction Marjan M. Fretz Gert Storm 349

25 ATP-Loaded Liposomes for Targeted Treatment in Models of Myocardial Ischemia Tatyana S. Levchenko William C. Hartner Daya D. Verma Eugene A. Bernstein Vladimir P. Torchilin 361

26 Intracellular ATP Delivery Using Highly Fusogenic Liposomes Sufan Chien 377

27 Lipoplex Formation Using Liposomes Prepared by Ethanol Injection Yoshie Maitani 393

28 Acid-Labile Liposome/pDNA Complexes Michel Bessodes Daniel Scherman 405

29 Serum-Resistant Lipoplexes in the Presence of Asialofetuin Conchita Tros de ILarduya 425

30 Anionic pH Sensitive Lipoplexes Nathalie Mignet Daniel Scherman 435

31 Liposomal siRNA Delivery Jeffrey Hughes Preeti Yadava Ryan Mesaros 445

32 Complexation of siRNA and pDNA with Cationic Liposomes: The Important Aspects in Lipoplex Preparation José Mario Barichello Tatsuhiro Ishida Hirosht Kiwada 461

33 Effective In Vitro and In Vivo Gene Delivery by the Combination of Liposomal Bubbles (Bubble Liposomes) and Ultrasound Exposure Ryo Suzuki Kazuo Maruyama 473

34 Liposomal Magnetofection Olga Mykbaylyk Yolanda Sánchez Antequera Dialekti Vlaskou Edelburga Hammerschmid Martina Anton Olivier Zelphati Christian Plank 487

35 Long-Circulating, pH-Sensitive Liposomes Denitsa Momekova Stanislav Rangelov Nikolay Lambov 527

36 Serum-Stable, Long-Circulating, pH-Sensitive PEGylated Liposomes Nicolas Bertrand Pierre Simard Jean-Christophe Leroux 545

Index 559

Editorial Reviews

From the reviews:

“The book provides in-depth descriptions of tumor and gene therapies, focusing on cationic liposomes. … The book presents the most seminal studies on the application of liposomes in the pharmaceutical area published over the past two decades. … the content provides the reader with a comprehensive overview of the topic and constitutes essential reading for those working or intending to work in the development of drug nanocarriers.” (Nádia Araci Bou Chacra, Brazilian Journal of Pharmaceutical Sciences, Vol. 46 (4), October-December, 2010)

“Provide a comprehensive guide to the preparation, characterisation, and potential use of currently known types of liposomes. They are written using an interdisciplinary approach, and so provide essential knowledge of liposomes, for not only researchers in this particular field, but also scientists in wider pharmaceutical and biological areas. … very inspiring – the potential for liposomes is immense – and these well-written chapters ignited notions of further applications – this is clearly a very exciting field.” (Trudy L. Knight, BTS Newsletter, Issue 37, Winter, 2010)

From the Publisher