The Man Who Invented the Chromosome: A Life of Cyril Darlington

by Oren Solomon Harman

Overview

Born by mistake, or connivance, to struggling parents in a small Lancashire cotton town in 1903, an uninspired Darlington inadvertently escaped the obscurity of farming life and rose instead, against all odds, to become within a few short years the world's greatest expert on chromosomes, and one of the most penetrating biological thinkers of the twentieth century. Harman follows Darlington's path from bleak prospects to world fame, showing how, within the most miniscule of worlds, he sought answers to the biggest questions—how species originate, how variation occurs, how Nature, both blind and foreboding, random and insightful, makes her way from deep past to unknown future. But Darlington did not stop there: Chromosomes held within their tiny confines untold, dark truths about man and his culture. This passionate conviction led the once famed Darlington down a path of rebuke, isolation, and finally obscurity.

As The Man Who Invented the Chromosome unfolds Darlington's forgotten tale—the Nazi atrocities, the Cold War, the crackpot Lysenko, the molecular revolution, eugenics, Civil Rights, the welfare state, the changing views of man's place in nature, biological determinism—all were interconnected. Just as Darlington's work provoked him to ask questions about the link between biology and culture, his life raises fundamental questions about the link between science and society.

Product Details

ISBN-13:	9780674013339
Publisher:	Harvard University Press
Publication date:	06/15/2004
Pages:	342
Product dimensions:	6.12(w) x 9.25(h) x 1.00(d)

About the Author

Oren Solomon Harman is Lady Davis Fellow at The Hebrew University of Jerusalem and Lecturer at Bar-Ilan University.

Table of Contents

Introduction

I. Adventures in Lancashire

1. An Improbable Birth

2. A Rising Tide

3. Auspicious Beginnings

4. In Search of Tulips and Truth

II. Science

5. From Cytology to Evolution

6. Roots of a Scientific Controversy

7. Method, Discipline and Character

Interlude

III. Politics

8. The Lysenko Affair

9. Marxism and the Slaying of a Mentor

10. Science in a Changing World

IV. Man

11. The Conflict of Science and Society

12. On the Determination of Uncertainty

13. The Breakdown of Classical Genetics

14. On the Uncertainty of Determination

15. One Final Hurrah

Conclusion: Paradoxes

Bibliography

Index

What People are Saying About This

Highly original and brilliantly accomplished, this is the first scholarly biography of Darlington and a richly effective one. Harman has based it on Darlington's diaries, letters, and other papers, on extensive reading in other primary sources, and on authoritative knowledge of the secondary literature. The author wears his learning lightly, deftly integrating his research into a highly readable, engaging, and lucid narrative. It will surely find an appreciative audience among geneticists, evolutionary biologists, and cytologists as well as among historians of those fields and of eugenics.

Daniel J. Kevles

Highly original and brilliantly accomplished, this is the first scholarly biography of Darlington and a richly effective one. Harman has based it on Darlington's diaries, letters, and other papers, on extensive reading in other primary sources, and on authoritative knowledge of the secondary literature. The author wears his learning lightly, deftly integrating his research into a highly readable, engaging, and lucid narrative. It will surely find an appreciative audience among geneticists, evolutionary biologists, and cytologists as well as among historians of those fields and of eugenics.
— Daniel J. Kevles, author of The Baltimore Case: A Trial of Politics, Science, and Character

Editorial Reviews

Harman does a good job of explaining the complex intellectual and technical problems in genetics and cytology and helps us understand the central importance of cytology to the modern conception of genes and genetic processes… This book clearly fills a void. Darlington should be better known, to both historians and scientists alike… This is a book that nobody who is interested in the history of twentieth-century genetics can afford to overlook.

Journal of the History of Medicine - Manfred D. Laubichler

Cyril Darlington was the leading cytologist in Britain between 1930 and 1950, and a major figure in the British genetics community, as well-known for his cantankerous personality as for his science… Overall, Harman has done an excellent job of portraying Darlington’s stormy personal and scientific life, bringing out his flaws as well as his achievements.

Nature Medicine - Brian Charlesworth

Harman’s brilliant book—the first and, almost surely, the definitive biography—wrests the earlier Darlington from the later crank, recovering him as a human being and restoring him to scientific eminence. Drawing on Darlington’s voluminous papers, correspondence, and diaries, Harman recounts the personal odyssey that took his subject from a bleak childhood to high achievement in the new genetics; his scientific and political engagements, particularly his differences over Lysenko with his fellow biologists, many of them on the left; and his slide into the cantankerous biological conservatism that marked his later years. Harman writes in supple prose and with capacious discernment, providing a portrait of the man that is at once empathetic and critical, a study in character and personality that illuminates his science as well as his personal and professional lives.

New Republic - Daniel J. Kevles

Darlington’s archives are a rich seam to which Oren Solomon Harman brings a keen eye. He combines impressive contextual knowledge with touches of biographical flair.

New Scientist - Marek Kohn

As Oren Solomon Harman shows in The Man Who Invented the Chromosome, Darlington’s controversial cytological research clarified many basic biological issues and provided essential evidence for the evolutionary synthesis of the 1940s. He ‘invented’ the chromosome by describing its behaviour in a way that made genetic and evolutionary sense… A strong commitment to an evolutionary perspective led Darlington to some unpopular conclusions, which he published in books and articles aimed at a wide audience. Convinced that biological principles, especially genetics, dictate human values, he espoused strong eugenic programmes… He felt that the time had come for science to determine morality: religion and politics should be replaced by evolutionary logic for individuals, countries and humanity… Harman provides a cautionary tale for those who seek to tie our humanity too closely to what is found in our chromosomes.

Nature - Rena Selya

Harman does a good job of explaining the complex intellectual and technical problems in genetics and cytology and helps us understand the central importance of cytology to the modern conception of genes and genetic processes…This book clearly fills a void. Darlington should be better known, to both historians and scientists alike…This is a book that nobody who is interested in the history of twentieth-century genetics can afford to overlook.
— Manfred D. Laubichler, PhD

Journal of the History of Medicine

Harman's brilliant book—the first and, almost surely, the definitive biography—wrests the earlier Darlington from the later crank, recovering him as a human being and restoring him to scientific eminence. Drawing on Darlington's voluminous papers, correspondence, and diaries, Harman recounts the personal odyssey that took his subject from a bleak childhood to high achievement in the new genetics; his scientific and political engagements, particularly his differences over Lysenko with his fellow biologists, many of them on the left; and his slide into the cantankerous biological conservatism that marked his later years. Harman writes in supple prose and with capacious discernment, providing a portrait of the man that is at once empathetic and critical, a study in character and personality that illuminates his science as well as his personal and professional lives.
— Daniel J. Kevles

New Republic

As Oren Solomon Harman shows in The Man Who Invented the Chromosome, Darlington's controversial cytological research clarified many basic biological issues and provided essential evidence for the evolutionary synthesis of the 1940s. He 'invented' the chromosome by describing its behaviour in a way that made genetic and evolutionary sense...A strong commitment to an evolutionary perspective led Darlington to some unpopular conclusions, which he published in books and articles aimed at a wide audience. Convinced that biological principles, especially genetics, dictate human values, he espoused strong eugenic programmes...He felt that the time had come for science to determine morality: religion and politics should be replaced by evolutionary logic for individuals, countries and humanity...Harman provides a cautionary tale for those who seek to tie our humanity too closely to what is found in our chromosomes.
— Rena Selya

Nature

Cyril Darlington was the leading cytologist in Britain between 1930 and 1950, and a major figure in the British genetics community, as well-known for his cantankerous personality as for his science...Overall, Harman has done an excellent job of portraying Darlington's stormy personal and scientific life, bringing out his flaws as well as his achievements.
— Brian Charlesworth

Nature Medicine

Darlington's archives are a rich seam to which Oren Solomon Harman brings a keen eye. He combines impressive contextual knowledge with touches of biographical flair.
— Marek Kohn

New Scientist