Mechanisms of Atrial Arrhythmias: Insights from the Development of a Biophysically Detailed Model of the Human Atria

by Michael A. Colman

Overview

This thesis describes the development of biophysically detailed computer models of the human atria and torso to study the underlying mechanisms of cardiac diseases, some of the most common causes of morbidity and mortality. This is a cross-disciplinary project, involving fundamentals of cardiac electrophysiology, physics of excitable media, applied mathematics and high performance scientific computing and visualisation. The author uses computer models to provide insights into the underlying mechanisms of the genesis of atrial fibrillation and develops novel techniques for the monitoring of atrial tachycardia.

Product Details

ISBN-13:	9783319348773
Publisher:	Springer International Publishing
Publication date:	11/19/2014
Series:	Springer Theses
Edition description:	Softcover reprint of the original 1st ed. 2014
Pages:	256
Product dimensions:	6.10(w) x 9.25(h) x 0.02(d)

Table of Contents

Introduction.- Background.- Development of a new model for simulating the electrical action potentials of human atrial myocytes.- Development of a family of regional cell models.- Autonomic regulation and pathophysiological remodelling.- 3D Anatomical Modelling of the Atria.- Pacemaking and autonomic regulation in the 3D sinoatrial node and atria.- Atrial Fibrillation.- Discussion.