Membrane Bioenergetics

Membrane Bioenergetics

by Vladimir P. Skulachev

Paperback(Softcover reprint of the original 1st ed. 1988)

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Product Details

ISBN-13: 9783642729805
Publisher: Springer Berlin Heidelberg
Publication date: 04/03/2013
Edition description: Softcover reprint of the original 1st ed. 1988
Pages: 442
Product dimensions: 6.69(w) x 9.61(h) x 0.04(d)

Table of Contents

1 Introduction.- 1.1 A “Biology Building” and the Place of Bioenergetics.- 1.2 Essential Definitions.- 1.2.1 Energy-Transducing Membranes.- 1.2.2 Coupling Ions.- 1.2.3 Convertible Energy Currencies of the Living Cell.- 1.3 ??¯H, ?p, ??¯Na and ?s.- 1.4 Adenosine Triphosphate.- 1.5 Membrane Lipids.- 1.6 Lipid Bilayer.- 1.7 Membrane Proteins.- 2 Specific Methods of Membrane Bioenergetics.- 2.1 Membrane Potential Measurement.- 2.1.1 Proteoliposomes.- 2.1.2 Direct ?? Measurement in the Proteoliposome-Collodion Film System.- 2.1.3 ?? Measurement in Intact Cells and Organelles.- Microelectrode Techniques.- Natural Penetrating Ions and Ionophores.- Synthetic Penetrating Ions.- Fluorescing Penetrating Ions: A ?? Monitoring in a Single Cell or Organelle.- The Carotenoid Shift.- 2.2 ?pH Measurement.- 2.3 Measurement of Fast H+ Dissociation-Association.- 3 Primary ??¯H Generators.- 3.1 The Cyclic Photoredox Chain of Purple Bacteria.- 3.1.1 The Main Components and the Principle of Their Function.- 3.1.2 The Reaction Centre Complex.- The Protein Composition.- The Arrangement of Redox Groups.- The Sequence of Electron Transfer Events.- The Mechanism of ??¯H Generation.- 3.1.3 The CoQH2-Cytochrorne c Reductase.- 3.1.4 The Fate of Generated ??¯H.- 3.2 The Non-Cyclic Photoredox Chain of Green Bacteria.- 3.3 The Non-Cyclic Photoredox Chain of Chloroplasts and Cyanobacteria.- 3.3.1 The Principle of Functioning.- 3.3.2 Photosystem I.- The Subunit Composition.- The Electron Transfer Mechanism.- The Mechanism of ??¯H Generation.- 3.3.3 Photosystem II.- 3.3.4 PQH2-Plastocyanin Reductase.- 3.3.5 The Fate of ??¯H Generated by the Chloroplast Photosynthetic Redox Chain.- 3.4 The Respiratory Chain.- 3.4.1 The Principle of Functioning.- 3.4.2 The Sources of Reducing Equivalents.- 3.4.3 NADH-CoQ Reductase.- Protein Composition and Redox Centres.- Proof of ??¯H Generation.- Possible Mechanisms of ??H Generation.- 3.4.4 The CoQH2-Cytochrome c Reductase.- Structural Aspects.- A Functional Model.- Interrelations of CoQ(PQ)-Cytochrome c Reductases in Respiratory and Photosynthetic Redox Chains.- 3.4.5 Cytochrome Oxidase.- Cytochrome c.- The Structure of Cytochrome c Oxidase.- Electron Transfer Path.- The Mechanism of ??¯H Generation.- 3.4.6 A Three-Cycle Version of the Respiratory Chain.- 3.4.7 Shortened Versions of the ??¯H Generating Respiratory Chain.- Reduction of Nitrate.- Reduction of Fumarate.- Methanogenesis.- Oxidations of Substrates of a Positive Redox Potential.- 3.4.8 The Pathways and the Efficiency of Utilization of Respiratory ??¯H. P/O Ratio.- 3.5 Bacteriorhodopsin.- 3.5.1 The Principle of Functioning.- 3.5.2 The Structure of Bacteriorhodopsin.- 3.5.3 Lipids of the Bacteriorhodopsin Sheets.- 3.5.4 Organization of the Bacteriorhodopsin Sheet.- 3.5.5 Bacteriorhodopsin Photocycle.- 3.5.6 Uphill H+ Transport by Bacteriorhodopsin.- Correlation of Photocycle, ?? Generation, H+ Release and Uptake.- A Possible Mechanism of H+ Pumping.- 3.5.7 Bacteriorhodopsin in the Dark. Problem of H+ Leakage.- 3.5.8 Other Retinal Proteins.- Halorhodopsin.- Halobacterial Sensory Rhodopsin and Phoborhodopsin.- Animal Rhodopsin.- 3.6 Primary ??¯H Generators: Overview.- 3.6.1 The Number of ??¯H Generators in the Living Systems of Various Types.- 3.6.2 Interrelations of H+ and ? Transfer in ??¯H Generating Mechanisms.- 4 Secondary ??¯H Generators: H+-ATPases.- 4.1 Definition and Classification.- 4.2 H+-ATPasesof Obligate Anaerobic Bacteria.- 4.3 H+-ATPase of the Plant and Fungal Outer Cell Membrane.- 4.4 H+-ATPase of Tonoplast.- 4.5 Non-Mitochondrial H+-ATPase in Animal Cells.- 4.5.1 H+-ATPase of Chromafin Granules.- 4.5.2 Other H+-ATPase.- 4.5.3 Gastric Mucosa H+/K+ ATPase.- 4.6 Interrelation of Various Functions of H+-ATPase.- 5 ??¯H Consumers.- 5.1 ??¯H-Driven Chemical Work.- 5.1.1 H+-ATP Synthase.- Subunit Composition.- A Three-Dimensional Structure and Arrangement in the Membrane.- ATP Hydrolysis by Isolated F1.- Synthesis of Bound ATP by Isolated Factor F1.- F0-Mediated H+ Conductance.- ??¯H-ATP Interconversion by H+-ATP Synthase in Proteoliposomes.- H+/ATP Stoichiometry.- Possible Mechanisms of Energy Transduction.- Can Localized ??¯H be Involved in ATP Synthesis?.- 5.1.2 H+-Pyrophosphate Synthase.- 5.1.3 H+-Transhydrogenase.- General Characteristics.- The Mechanism of Energy Transduction.- Biological Functions.- Other Systems of the Reverse Transfer of Reducing Equivalents.- 5.2 ??¯H-Driven Osmotic Work.- 5.2.1 Definition and Classification.- 5.2.2 ?? as the Driving Force.- 5.2.3 ApH as the Driving Force.- 5.2.4 Total ??¯H as the Driving Force.- 5.2.5 ??¯H-Driven Transport Cascades.- 5.2.6 Carnitine: An Example of the Transmembrane Group Carrier.- 5.2.7 Some Examples of Proteins Catalyzing ??¯H-Driven Transports.- E.coli Lactose, H+ Symporter.- Mitochondrial ATP/ADP Antiporter.- Mitochondrial H2PO4-, H+ Symporter.- 5.2.8 The Role of ??¯H in the Transport of Marcomolecules.- Transport of Mitochondrial Proteins, Biogenesis of Mitochondria.- Transport of Bacterial Proteins.- The Role of ??¯H in Transmembrane Protein Movement and Arrangement.- Bacterial DNA Transport.- 5.3 ??¯H-Driven Mechanical Work: Bacterial Motility.- 5.3.1 The Structure of the Bacterial Flagellar Motor.- 5.3.2 ??¯H Powers the Flagellar Motor.- 5.3.3 A Possible Mechanism of the H+ Motor.- 5.3.4 ??¯H-Driven Movement of Non-Flagellar Motile Prokaryotes and Intracellular Organelles.- 5.3.5 Motile Eukaryote-Prokaryote Symbionts.- 5.4 ??¯H as an Energy Source for Heat Production.- 5.4.1 Three Ways of Converting Metabolic Energy into Heat.- 5.4.2 Thermoregulatory Activation of Free Respiration in Animals.- Skeletal Muscles.- Brown Fat.- Liver.- 5.4.3 Thermoregulatory Activation of Free Respiration in Plants.- 6 ??¯H Regulation, Transmission and Buffering.- 6.1 Regulation of ??¯H.- 6.1.1 Alternative Functions of Respiration.- 6.1.2 Regulation of the Flows of Reducing Equivalents Between Cytosol and Mitochondria.- 6.1.3 ?? - ApH Interconversion.- 6.1.4 Relation of the ??¯H Control to the Main Regulatory Systems of Eukaryotic Cells.- 6.1.5 ??¯H Control in Bacteria.- 6.2 ??¯H Transmission.- 6.2.1 General Remarks.- 6.2.2 Lateral Transmission of AjiH Produced by Light -Dependent Generators in Halobacteria and Chloroplasts.- 6.2.3 Transcellular Power Transmission Along Cyanobacterial Trichomes.- 6.2.4 The Structure and Functions of Filamentous Mitochondria and Mitochondrial Reticulum.- The Dogma of Small Mitochondria.- Giant Mitochondria and Reticulum mitochondriale.- Filamentous Mitochondria.- Mitochondria as Intracellular Proton Cables: Verification of the Hypothesis.- The Possible Mechanism of Lateral ??¯H Transmission.- Lateral Transport of Ca2 +, Fatty Acids and Oxygen.- Lateral Transport of the Reducing Equivalents.- Cytochrome b5-Mediated Intermembrane Electron Transport.- 6.3 ??¯H Buffering.- 6.3.1 Na+/K+ Gradients as a ??¯H Buffer in Bacteria.- 6.3.2 Other ??¯H — Buffering Systems.- 6.3.3 Carnosine and Anserine as Specialized pH Buffers.- 7 The Sodium World.- 7.1 ??¯Na Generators.- 7.1.1 Na+- Motive Decarboxylases.- 7.1.2 Na+- Motive Respiratory Chain.- 7.1.3 Na+-ATPases.- Bacterial Na+- ATPases.- Animal Na+/K+ ATPase and Na+ ATPase.- 7.2 Utilization of ??¯Na Produced by Primary ??¯Na Generators.- 7.2.1 Osmotic Work.- Na+, Solute — Symports.- Na+ Ions and Regulation of the Cytoplasmic pH.- 7.2.2 Mechanical Work.- 7.2.3 Chemical Work.- The ??¯Na-Driven ATP Synthesis in Anaerobic Bacteria.- Na+-Coupled Respiratory Phosphorylation in Vibrio alginolyticus.- 7.3 How Often is the Na+ Cycle Used by Living Cells?.- 7.4 Probable Evolutionary Relationships of the Protonic and Sodium Worlds.- 7.5 Na+/H+ Antiport in the Animal Cell: H+ as a Secondary Messenger.- 7.6 A General Scheme of Interrelations of Protonic and Sodium Cycles.- 7.7 Membrane-Linked Energy Transductions when Neither H+ nor Na+ is Involved.- 8 Membrane Bioenergetics Studies: An Outlook.- 8.1 Some Prospects for Fundamental Research.- 8.2 Towards Applied Membrane Bioenergetics.- 8.2.1 Medical Aspects.- Respiratory Chain Defects and Related Cases.- Cancer: The Role of Na+/H+Antiporter.- Cancer: Penetrating Cations as Antitumour Agents.- The Action of Antimicrobial Agents, Mediated by Membrane Bioenergetic Systems.- 8.2.2 Two Examples of Possible Technological Application.- ATP Regeneration at the Expense of Light Energy.- The Na+ Cycle in Useful Bacteria.- 9 Membrane Bioenergetics: A Look into History.- 9.1 The First Ideas and Observations. Chemiosmotic Hypothesis.- 9.2 Uncouplers.- 9.3 ??¯H Across Natural Membranes.- 9.4 ??¯H Across Reconstituted Membranes.- 9.5 ATP Formation Supported by an Artifically Imposed ??¯H.- 9.6 Bacteriorhodopsin and Chimerical Proteoliposomes.- 9.7 The Latest History.- 9.8 Membrane Bioenergeticists and Their Outstanding Predecessors.- 10 References.- 11 Subject Index.

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