ISBN-10:
1119130484
ISBN-13:
9781119130482
Pub. Date:
04/18/2016
Publisher:
Wiley
Method of Lines PDE Analysis in Biomedical Science and Engineering / Edition 1

Method of Lines PDE Analysis in Biomedical Science and Engineering / Edition 1

by William E. Schiesser
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Product Details

ISBN-13: 9781119130482
Publisher: Wiley
Publication date: 04/18/2016
Pages: 370
Product dimensions: 6.20(w) x 9.50(h) x 1.10(d)

About the Author

William E. Schiesser, PhD, ScD (hon.), is Emeritus McCann Professor of Biomolecular and Chemical Engineering and Professor of Mathematics at Lehigh University. His research interests include numerical software; ordinary, differential algebraic, and partial differential equations; and computational mathematics. Dr. Schiesser is the author or coauthor of fifteen books, including Differential Equation Analysis in Biomedical Science and Engineering: Ordinary Differential Equation Applications with R and Differential Equation Analysis in Biomedical Science and Engineering: Partial Differential Equation Applications with R, both published by Wiley.

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Table of Contents

Preface xi
About the Companion Website xiii

1 An Introduction to MOL Analysis of PDEs: Wave Front Resolution in Chromatography 1
1.1 1D 2-PDE model, 2
1.2 MOL routines, 7
1.2.1 Main program, 7
1.2.2 MOL/ODE routine, 16
1.2.3 Subordinate routines, 20
1.3 Model output, single component chromatography, 21
1.3.1 FDs, step BC, 21
1.3.2 Flux limiters, step BC, 39
1.3.3 FDs, pulse BC, 48
1.3.4 Flux limiters, pulse BC, 50
1.4 Multi component model, 53
1.5 MOL routines, 54
1.5.1 Main program, 54
1.5.2 MOL/ODE routine, 62
1.6 Model output, multi component chromatography, 67
References, 68

2 Wave Front Resolution in VEGF Angiogenesis 69
2.1 1D 2-PDE model, 70
2.2 MOL routines, 72
2.2.1 Main program, 72
2.2.2 MOL/ODE routine, 81
2.2.3 Subordinate routines, 85
2.3 Model output, 86
2.3.1 Comparison of numerical and analytical solutions, 86
2.3.2 Effect of diffusion on the traveling-wave solution, 88
2.4 Conclusions, 88
References, 89

3 Thermographic Tumor Location 91
3.1 2D, 1-PDE model, 92
3.2 MOL analysis, 94
3.2.1 ODE routine, 94
3.2.2 Main program, 100
3.3 Model output, 105
3.4 Summary and conclusions, 110
References, 111

4 Blood-Tissue Transport 113
4.1 1D 2-PDE model, 114
4.2 MOL routines, 115
4.2.1 MOL/ODE routine, 115
4.2.2 Main program, 119
4.2.3 Bessel function routine, 128
4.3 Model output, 129
4.4 Model extensions, 133
4.5 Conclusions and summary, 142
References, 143

5 Two-Fluid/Membrane Model 145
5.1 2D, 3-PDE model, 146
5.2 MOL analysis, 147
5.2.1 MOL/ODE routine, 148
5.2.2 Main program, 153
5.3 Model output, 160
5.4 Summary and conclusions, 162

6 Liver Support Systems 165
6.1 2-ODE patient model, 166
6.2 Patient ODE model routines, 167
6.2.1 Main program, 167
6.2.2 ODE routine, 172
6.3 Model output, 174
6.4 8-PDE ALSS model, 176
6.4.1 Membrane unit MU1, 177
6.4.2 Adsorption unit AU1, 177
6.4.3 Adsorption unit AU2, 178
6.4.4 Membrane unit MU2, 179
6.5 Patient-ALSS ODE/PDE model routines, 180
6.5.1 Main program, 180
6.5.2 ODE routine, 188
6.6 Model output, 195
6.7 Summary and conclusions, 196
Appendix - Derivation of PDEs for Membrane and Adsorption Units, 200
A.1 PDEs for Membrane Units, 200
A.2 PDEs for Adsorption Units, 202
References, 203

7 Cross Diffusion Epidemiology Model 205
7.1 2-PDE model, 205
7.2 Model routines, 207
7.2.1 Main program, 207
7.2.2 ODE routine, 215
7.3 Model output, 218
7.3.1 ncase = 1, time-invariant solution, 218
7.3.2 ncase = 2, transient solution, no cross diffusion, 220
7.3.3 ncase = 3, transient solution with cross diffusion, 222
7.4 Summary and conclusions, 224
Reference, 225

8 Oncolytic Virotherapy 227
8.1 1D 4-PDE model, 228
8.2 MOL routines, 229
8.2.1 Main program, 230
8.2.2 MOL/ODE routine, 240
8.2.3 Subordinate routine, 245
8.3 Model output, 246
8.4 Summary and conclusions, 273
Reference, 274

9 Tumor Cell Density in Glioblastomas 275
9.1 1D PDE model, 276
9.2 MOL routines, 277
9.2.1 Main program, 277
9.2.2 MOL/ODE routine, 286
9.3 Model output, 289
9.3.1 Output for ncase = 1, linear, 290
9.3.2 Output for ncase = 2, logistic, 295
9.3.3 Output for ncase = 3, Gompertz, 296
9.4 p-refinement error analysis, 299
9.5 Summary and conclusions, 301
References, 301

10 MOL Analysis with a Variable Grid: Antigen-Antibody Binding Kinetics 303
10.1 ODE/PDE model, 303
10.2 MOL routines, 306
10.2.1 Main program, 306
10.2.2 MOL/ODE routine, 314
10.3 Model output, 318
10.3.1 Uniform grid, 318
10.3.2 Variable grid, 321
10.4 Summary and conclusions, 325
Appendix: Variable Grid Analysis, 327
A.1 Derivation of numerical differentiators, 327
A.2 Testing of numerical differentiators, 331
A.2.1 Differentiation matrix, 331
A.2.2 Test functions, 332
References, 340

Appendices
Appendix A Derivation of Convection-Diffusion-Reaction
Partial Differential Equations 341
Appendix B Functions dss012, dss004, dss020, vanl 345
Index 351

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