Mitochondria and Cell Death

by David M. Hockenbery

Overview

This volume examines the role of mihondria in different types of cell death, including apoptotic and necrotic cell deaths. Topics discussed include mihondrial outer membrane permeabilization (MOMP) and the permeability transition pore; core processes such as calcium handling, fission and fusion, reactive oxygen species generation, and maintenance of mihondrial DNA fidelity and protein folding homeostasis; and retrograde signaling between mihondria and other cellular components, including the important role of mihondria in antiviral immunity. The expertly authored chapters are drawn from multidisciplinary international perspectives, lending a nuanced and comprehensive approach to the material.

Mihondria and Cell Death, part of the Cell Death in Biology and Diseases series, is invaluable reading for graduate students, researchers, and clinicians in the fields of neuroscience, oncology, gastroenterology, and hepatology,as well as those interested in the study of mihondria and cell biology.

Product Details

ISBN-13:	9781493980949
Publisher:	Springer New York
Publication date:	05/30/2018
Series:	Cell Death in Biology and Diseases
Edition description:	Softcover reprint of the original 1st ed. 2016
Pages:	232
Product dimensions:	6.10(w) x 9.25(h) x (d)

About the Author

David M. Hockenbery, MD is Professor, Member & Head of the Gastroenterology & Hepatology Section of the Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance. He is also a Mentor in the Seattle Children’s/UW/Hutchinson Center Pediatric Hematology-Oncology Fellowship Program. He received his M.D. from Washington University in St. Louis, completed his Residency in Medicine at Johns Hopkins and also completed two Fellowships, in Gastroenterology and Molecular Oncology, at Washington University. Dr. Hockenbery’s current research interests include the bcl-2 oncogene and its role in apoptosis, mihondrial biology and bioenergetic metabolism, utilizing cell culture, transgenic mouse and protein biochemistry approaches for identification of cancer-selective metabolic pathways and discovery of small molecule inhibitors targeting these pathways.

Table of Contents

Preface.- 1.Lethal and non-lethal functions of the permeability transition pore.- 2.Mihondrial Calcium and Ischemia-Reperfusion Injury in
Heart.- 3.Mislocalization of mihondrial intermembrane space proteins.- 4.Bcl-2 protein interplay on the outer mihondrial membrane.- 5.Remodeling of Mihondria in Apoptosis.- 6.Physiologic and Pathologic Functions of Mihondrial ROS.- 7.Mihondrial Mutagenesis in Cancer.- 8.Mihondrial UPR in cancer.- 9.Mihondrial signaling.- 10.Mihondria and antiviral immunity.- 11.Mihondrial permeabilization from lethality to vitality.- Index.